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961.
Little has so far been known about the role of antigen-presenting cells (APCs) in the activation of T cells by superantigens. Recently several studies showed that superantigens could directly activate purified T cells in the presence of CD28 costimulation. Here we investigate V beta expression of T cells activated by the superantigen toxic shock syndrome toxin-1 (TSST-1), plus CD28 costimulation, in the absence of APCs. The aim of this study was to ask if TSST-1 activated purified T cells in the presence of CD28 costimulation with the same specificity as in the presence of APCs. We provide evidence that the specificity of TSST-1 to human V beta, in the presence of CD28 costimulation, is identical to that in the presence of APCs, with V beta 2 being significantly expanded. The results indicate that the main role of APCs in the superantigen-mediated T cell activation may be to provide T cells with CD28 costimulation.  相似文献   
962.
963.
A composite of O′SiAlON (Si2-xAlxN2-xO1+x, with x 0.14) reinforced with 20 vol.% SiC monofilaments was fabricated by hot-pressing, at 1600°C, for 2 h under 34 MPa pressure. The mechanical and interfacial properties of the composites, as-fabricated as well as post-oxidized, were, investigated. The composite exhibited a significant improvement in ultimate flexure strength (640 MPa) and work of fracture (42 kJ m−2) compared with that (350 MPa and 1.8 kJ m−2, respectively) of the monolithic material. These mechanical properties were slightly increased after the composite was heat treated for 24 h in air at 1200 and 1300°C. However, the composite exhibited a significant degradation in ultimate strength, while the work of fracture (WOF) remained unchanged after exposure in air at temperatures beyond 1400°C. The as-fabricated composite revealed a low interfacial shear strength (6.2 MPa) and a frictional sliding stress (3.2 MPa). After the composite was oxidized at elevated temperatures, the interfacial bonding and sliding stresses were reduced to noticeable extents, resulting from the degradation of the carbon coating layer of the SiC monofilaments.  相似文献   
964.
965.
研制了一台准分子激光心血管治疗机(XeCl308nm),单脉冲能量:80-200mJ,平均功率5W,重复频率:手动单次,1-100Hz,单次充气工作寿命:>106脉冲数,脉冲-脉冲的能量不稳定度3%,激光脉宽150ns,光斑发散角(半角):1.8×0.6mrad,光纤耦合输出>20mJ。  相似文献   
966.
This review reports the different genetic factors that have been identified either as risk factor for Alzheimer's disease (AD) or directly causing the disease. First are reviewed epidemiological data and biological mechanisms about the apoplipoprotein E gene allele epsilon 4 that is a major risk factor for Alzheimer's disease. The second part describes the mutations responsible for early-onset autosomal dominant AD found in three different genes. The gene located on chromosome 21 encodes the amyloid precusor protein (APP). The presenilin 1 and presenilin 2 genes, located on chromosome 14 and 1 respectively, encode not yet known membrane proteins.  相似文献   
967.
对现行的森林火情监测方法进行了分析比较。根据实际存在的难题,提出了料为产用的实施方案及应采取的技术措施,进行了实地试验,取得较好的效果。  相似文献   
968.
The phase behavior of a hybrid polymer network (HPN) composed of poly[(propylene glycol maleate)-co-(propylene glycol phthalate)] crosslinked with styrene and polyester–urethane crosslinked with methylene-bis-ortho-chloroaniline was examined. The correlation between phase separation and impact strength of the HPNs is discussed. The composition of HPNs has an effect on their properties.  相似文献   
969.
970.
The performance of the conventional predictive current control (PCC) when applied to a permanent-magnet brushless ac (PM BLAC) drive is analyzed. A technique is proposed to reduce the current errors that arise due to the inaccuracies in the system parameters and the nonideal behavior of the inverter during a steady-state operation. In addition, a current-regulated delta modulator is employed to achieve a fast dynamic response during a transient operation. The performance of the proposed PCC, which is simple to implement on a low-cost fixed-point DSP, is demonstrated experimentally.  相似文献   
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