miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Lung cancer is the leading cause of cancer death worldwide. miR-199a, which has two mature molecules: miR-199a-3p and miR-199a-5p, plays an important biological role in the genesis and development of tumors. We collected recent research results on lung cancer and miR-199a from Google Scholar and PubMed databases. The biological functions of miR-199a in lung cancer are reviewed in detail, and its potential roles in lung cancer diagnosis and treatment are discussed. With miR-199a as the core point and a divergence outward, the interplay between miR-199a and other ncRNAs is reviewed, and a regulatory network covering various cancers is depicted, which can help us to better understand the mechanism of cancer occurrence and provide a means for developing novel therapeutic strategies. In addition, the current methods of diagnosis and treatment of lung cancer are reviewed. Finally, a conclusion was drawn: miR-199a inhibits the development of lung cancer, especially by inhibiting the proliferation, infiltration, and migration of lung cancer cells, inhibiting tumor angiogenesis, increasing the apoptosis of lung cancer cells, and affecting the drug resistance of lung cancer cells. This review aims to provide new insights into lung cancer therapy and prevention.     

基于阅读2.0模式,高校馆学生读者网络阅读推广分析

阅读2.0是全民阅读推广的新理念.本文简述了阅读2.0的明显特征及两大优势,并结合长春高校图书馆的调查数据,分析了高校大学生网络阅读现状.     

RS(255,223)译码器的设计与FPGA实现

RS码是一种多进制分组循环码。检错和纠错能力强．尤其适合纠正突发错误，在通信系统中有着广泛的应用。本文所研究的RS(255，223)译码器采用修正的Euclid译码算法(MEA)，介绍了一种基于FPGA的RS译码器的设计和硬件电路实现方案。按照自顶向下的设计流程．划分模块．详细论述了各子模块的设计过程。     

多接口移动主机最优化费用和性能方法研究

目前移动主机普遍具有多个网络接口,可以由这些接口通过不同的网络服务提供商(ISP)接入到Internet中.因此,移动主机与Internet之间就可能存在多条路径,通信的费用和性能取决于ISP的收费策略和网络通信性能.文中首先对移动主机与Internet通信进行建模,然后提出一种基于主动探测可用路径的最优化费用和性能的...     

Electrolyte-mediated dense integration of graphene-MXene films for high volumetric capacitance flexible supercapacitors

High conductivity two-dimensional(2D)materials have been proved to be potential electrode materials for flexible supercapacitors because of its outstanding chemical and physical properties.However,electrodes based on 2D materials always suffer from limited electrolyte-accessible surface due to the restacking of the 2D sheets,hindering the full utilization of their surface area.In this regard,an electrolyte-mediated method is used to integrate dense structure reduced graphene oxide/MXene(RGM)-electrolyte composite films.In such composite films,reduced graphene oxide(RGO)and MXene sheets are controllable assembly in compact layered structure with electrolyte filled between the layers.The electrolyte layer between RGO and MXene sheets forms continuous ion transport channels in the composite films.Therefore,the RGM-electrolyte composite films can be used directly as self-supporting electrodes for supercapacitors without additional conductive agents and binders.As a result,the composite films demonstrate enhanced volumetric specific capacity,improved volumetric energy density and higher power density compared with both pure RGO electrode and porous composite electrode prepared by traditional methods.Specifically,when the mass ratio of MXene is 30%,the electrode delivers a volumetric specific capacity of 454.9 F·cm^?3 with a high energy density of 39.4 Wh·L^?1.More importantly,supercapacitors based on the composite films exhibit good flexibility electrochemical performance.The investigation provides a new approach to synthesize dense structure films based on 2D materials for application in high volumetric capacitance flexible supercapacitors.     

PDA用于注射液中微粒检测的研究

本文以激光相位多普勒（ＰＤＡ）技术为基础,利用ＰＤＡ信号探测器及高速信号的处理系统,实现了注射液中不溶性微粒的尺寸分布检测,对ＰＤＡ技术的实用化研究进行了有益的探索。     

大型水电机组的无级调速技术

介绍了大型水电机组无级调速的两项先进技术,一是利用静止歇尔皮斯系统,另一是大型无换向器电机技术。     

城乡二元结构背景下中小学教师队伍的求变之路——以重庆市为例

城乡二元结构体制对教育产生了深刻的影响,尤其制约着农村教育的发展,优先发展教育,就必须优先发展教师教育,是实现城乡统筹发展背景下重庆市基础教育均衡发展的基本思路和策略选择.基于重庆市中小学教师队伍存在的问题,建议从完善政策保障机制、资源的优化配置、完善师资队伍培训机制、创新教师培养模式等方面来优化重庆市中小学教师队伍.     

用于内窥光学相干层析成像探头的小型化及焦深拓展技术

小型化探头是内窥光学相干层析成像(Optical coherence tomography,OCT)中的普遍需求。介绍了包括基于球透镜、光纤透镜、自聚焦光纤、自由曲面透镜、无透镜的OCT技术的发展历程,总结和比较了各种技术的优劣,为探头的小型化设计提出了建议。研究探头的焦深拓展技术对分辨人体内细胞的在体成像的发展具有重要意义。介绍了几种重要的适用于小型化探头的焦深拓展技术,其中基于模式干涉的探头由于易于制作、结构紧凑、传输效率高,同时具有可以优化工作距离、焦深和轴向光强均匀性的优点,在拓展小型化探头的焦深方面具有一定的发展潜力。     

基于深度学习的直肠癌放疗危及器官自动勾画的几何学和剂量学评估

基于几何学和剂量学指标评估基于深度学习的危及器官（Organs at risk, OARs）自动勾画的临床适用性,选取在复旦大学附属肿瘤医院接受放射治疗的35例直肠癌患者,采用自主开发的深度学习系统实现OARs自动勾画。以医生手动勾画的OARs作为参考,自动勾画的几何学评估指标包括戴斯相似系数（DSC）、雅卡尔相似系数（JSC）、豪斯多夫距离（HD）,平均一致性距离（MDA）。对于每个病例,基于自动勾画的OARs设计治疗计划,计划优化和评估过程与临床程序保持一致,记为Plan＿FD。比较Plan＿FD与原始临床治疗计划（记为Plan＿Treat）,以剂量体积参数和三维γ分析评估剂量学差异。自动勾画与手动勾画的OARs不仅在三维空间上高度重叠（DSC平均值大于0.85）,且在边缘细节上匹配度良好（MDA的平均值小于2.8 mm）。剂量学评估仅膀胱剂量（V30、V40、Dmean）有显著统计学差异（p<0.05）,其余OARs和靶区的剂量体积参数差异均无统计学意义。Plan＿FD与Plan＿Treat进行3 mm/3%标准的三维γ分析,γ≤1.0的点占比为（91.63±6.27）%。...