Properties and carbonization behavior of asphalt modified with the THF-soluble fraction of a coal liquefaction residue

This study focuses on the effects of the tetrahydrofuran-soluble fraction of direct coal liquefaction residue as a modifier to modify asphalt with formaldehyde. The properties and carbonization behavior of matrix asphalt and the modified asphalts were studied. The results indicate that the ductility properties of modified asphalts have been effectively improved. The morphology of modified asphalts without the addition of formaldehyde is a set of uniform distribution point, and it is converted from linear distribution to clustered distribution observed in fluorescence microscope images with the increase of the adding amount of formaldehyde.     

Enantioselective Construction of Cyclic Enaminone‐Based 3‐Substituted 3‐Amino‐2‐oxindole Scaffolds via Catalytic Asymmetric Additions of Isatin‐Derived Imines

The first catalytic asymmetric construction of the cyclic enaminone‐based 3‐substituted 3‐amino‐2‐oxindole scaffold with potential bioactivity has been developed via chiral phosphoric acid‐catalyzed enantioselective addition reactions of cyclic enaminones to isatin‐derived imines, which afforded a series of cyclic enaminone‐based 3‐substituted 3‐amino‐2‐oxindoles in high yields and excellent enantioselectivities (up to 99% yield, 97% ee). The investigation of the reaction mechanism suggested that it was facilitated by a dual hydrogen‐bonding activation mode between the two substrates and the chiral phosphoric acid. Besides, this method could be utilized for a large‐scale synthesis with maintained enantioselectivity. This approach will not only offer a useful method for enantioselective construction of the cyclic enaminone‐based 3‐substituted 3‐amino‐2‐oxindole scaffold, but also enrich the research on catalytic asymmetric addition reactions of isatin‐derived imines by using electron‐rich olefins as nucleophiles. More importantly, a preliminary evaluation on the cytotoxicity of some selected products revealed that two of the enantio‐pure compounds exhibited moderate to strong cytotoxicity to A549, 786‐0, ECA109 and BT474 cancer cell lines.

     

Protein A Detection Based on Quantum Dots-Antibody Bioprobe Using Fluorescence Coupled Capillary Electrophoresis

In this report, fluorescence detection coupled capillary electrophoresis (CE-FL) was used to detect Protein A. Antibody was first labeled with Cy5 and then mixed with quantum dots (QDs) to form QDs-antibody bioprobe. Further, we observed fluorescence resonance energy transfer (FRET) from QDs donor to Cy5 acceptor. The bioprobe was formed and brought QDs and Cy5 close enough to allow FRET to occur. After adding protein A, the FRET system was broken and caused the FRET signal to decrease. Thus, a new method for the determination of protein A was proposed based on the FRET signal changes. This study provides a new trail of thought for the detection of protein.     

关于小区给排水工程中质量问题的探讨

笔者结合自己的建筑工程施工实践经验,针对小区给排水工程中比较常见的质量问题进行了简单地介绍,并对问题提出了行之有效的预防和处理措施。     

Synthesis and dissociation of soliton molecules in parallel optical-soliton reactors

Mode-locked lasers have been widely used to explore interactions between optical solitons, including bound-soliton states that may be regarded as"photonic molec...     

调质型耐磨钢WNM400的研制开发

本文通过参考相关文献资料及国内外同等级别耐磨钢标准,设计了舞钢调质型耐磨钢WNM400A的化学成分,确定了冶炼及轧制工艺,研究了淬火、回火工艺对WNM400A钢性能的影响.     

新型一袋化堵漏技术在塔河油田中的应用

针对塔河油田奥陶系缝洞型储层易井漏、堵漏浆难以滞留、堵漏配方和工艺复杂的难题,提出了理想填充-紧密堆积理论结合的思路。通过优选可酸溶堵漏材料及其颗粒级配,研究形成封堵1～5 mm不同尺寸裂缝的5套堵漏配方,室内承压能力在10 MPa以上,酸溶率超过75%。上述堵漏配方分别生产为一袋化产品,在塔河油田X13H井和X193井奥陶系储层堵漏均一次成功。新型一袋化堵漏技术的配方颗粒级配和施工工艺合理有效,且实现了可酸溶解堵。     

塔河油田抽油杆断脱统计分析及优化对策

近年来抽油杆断脱成为塔河油田抽油机井检泵作业的主要因素,严重影响了油井正常生产,造成大量经济及产量损失。通过统计分析认为,交变载荷大造成的疲劳断以及泵挂深导致的抽油杆偏磨断是造成抽油杆断脱的主要原因。针对断脱的主要因素,在2015年开始从优化设计、加强管理、引入新技术等3个方面进行了综合治理,降低了杆断检泵频次,年节约修井费用181万元,年减少产量损失439 t,取得了较好的效益。     

Array-level boosting method with spatial extended allocation to improve the accuracy of memristor based computing-in-memory chips

Memristor based computing-in-memory chips have shown the potentials to accelerate deep neural networks with high energy efficiency.Due to the inherent filament-...