Prostate-specific antigen and its complexes with alpha 1-antichymotrypsin in the plasma of patients with prostatic disease

OBJECTIVE: To improve the specificity and sensitivity of the prostate-specific-antigen (PSA) assay for the distinction between prostate cancer and benign prostate hyperplasia (BPH). METHODS: Two sensitive immunoassays, one that measures free PSA and PSA complexed to alpha 1-antichymotrypsin (alpha 1-ACT) with the same efficiency (PSAag assay) and another that specifically measures the complex between PSA and alpha 1-ACT, have been designed to measure the PSA forms in the plasma of 84 patients with prostate disease and in the seminal plasma from 60 healthy individuals. RESULTS: The proportion of plasma PSA in complex with alpha 1-ACT was significantly higher in the 34 patients with prostate cancer (89 +/- 12%, mean +/- SD; median, 91%) than in the 50 patients with BPH (71 +/- 12%; 73%) and did not correlate with the total amount of PSA. Normal seminal plasma (n = 60) had 2.1 +/- 0.6 mg/ml PSA, 175 +/- 62 microns/ml alpha 1-ACT and 9.6 +/- 3.4 micrograms/ml PSA: alpha 1-ACT complex. CONCLUSION: These results confirm that PSA: alpha 1-ACT may be a good marker for a differential diagnosis of carcinoma of the prostate and BPH.     

Assessment of baroreceptor-cardiac reflex sensitivity using time domain analysis in patients with IDDM and the relation to left ventricular mass index

Autonomic dysfunction in insulin-dependent diabetic (IDDM) patients has been associated with abnormalities of left ventricular function and an increased risk of sudden death. A group of 30 patients with IDDM and 30 age, sex and blood pressure matched control subjects underwent traditional tests of autonomic function. In addition, baroreceptor-cardiac reflex sensitivity (BRS) was assessed using time domain (sequence) analysis of systolic blood pressure and pulse interval data recorded non-invasively using the Finapres beat-to-beat blood pressure recording system. 'Up BRS' sequences-increases in systolic blood pressure associated with lengthening of R-R interval, and 'down BRS' sequences-decreases in systolic blood pressure associated with shortening of R-R interval were identified and BRS calculated from the regression of systolic blood pressure on R-R interval for all sequences. We also assessed heart rate variability using power spectral analysis and, after expressing components of the spectrum in normalised units, assessed sympathovagal balance from the ratio of low to high frequency powers. IDDM subjects underwent 2-D echocardiography to assess left ventricular mass index. Standard tests of autonomic function revealed no differences between IDDM patients and control subjects, but dramatic reductions in baroreceptor-cardiac reflex sensitivity were detected in IDDM patients. 'Up BRS' when supine was 11.2 +/- 1.5 ms/mmHg (mean +/- SEM) compared with 20.4 +/- 1.95 in control subjects (p < 0.003) and when standing was 4.1 +/- 1.9 vs 7.6 +/- 2.7 ms/mmHg (p < 0.001). Down BRS when supine was 11.5 +/- 1.2 vs 22 +/- 2.6 (p < 0.001) and standing was 4.4 +/- 1.9 vs 7.3 +/- 2.5 ms/mmHg (p < 0.003). There were significant relations between impairment of the baroreflex and duration of diabetes (p < 0.001) and poor glycaemic control (p < 0.001). From a fast Fourier transformation of supine heart rate data and using a band width of 0.05-0.15 Hz as low-frequency and 0.2-0.35 Hz as high frequency total spectral power of R-R interval variability was significantly reduced in the IDDM group for both low-frequency (473 +/- 62.8 vs 746.6 +/- 77.6 ms2 p = 0.002) and high frequency bands 125.2 +/- 12.9 vs 459.3 +/- 89.8 ms2 p < 0.0001. When the absolute powers were expressed in normalised units the ratio of low frequency to high frequency power (a measure of sympathovagal balance) was significantly increased in the IDDM group (2.9 +/- 0.53 vs 4.6 +/- 0.55, p < 0.002 supine: 3.8 +/- 0.49 vs 6.6 +/- 0.55, p < 0.001 standing). Thus, time domain analysis of baroreceptor-cardiac reflex sensitivity detects autonomic dysfunction more frequently in IDDM patients than conventional tests. Impaired BRS is associated with an increased left ventricular mass index and this abnormality may have a role in the increased incidence of sudden death seen in young IDDM patients.     

Effect of lanthanide ions on the phase behavior of dipalmitoylphosphatidylcholine multilamellar liposomes

The effect of lanthanide ions (Ln3+) and their coordination compounds of diethylenetriamine pentaacetic acid (DTPA) on the phase behavior of dipalmitoylphosphatidylcholine (DPPC) multi-lamellar liposomes has been studied by differential scanning calorimetry (DSC), Raman spectroscopy, and freeze-fracture electron microscopic techniques. The displacement of Ca2+ binding on DPPC liposomes by lanthanide ions was also studied. The results show that the binding degree of four kinds of chloride salts with DPPC liposomes is: YbCl3 > GdCl3 > LaCl3 > CaCl2. Lanthanide ions increase the phase transition temperature of DPPC liposomes and decrease the membrane fluidity. Freeze-fracture electron microscopic results show that La3+ enhances the order of DPPC membrane. The effect of coordination compounds of lanthanides with DTPA on the phase behavior of DPPC liposomes is smaller than that of their chlorides. La3+, Gd3+, and Yb3+, can displace Ca2+ binding on DPPC liposomes, but there coordination compounds of DTPA can hardly displace Ca2+. Raman spectroscopic results show that a very slight effect in lateral packing order of DPPC liposomes was observed at various concentrations of lanthanides.     

A new MMIC broadside coupler using an array of air-bridges for directivity enhancement

A new quadrature broadside coupler is proposed, which employs an array of air-bridges to enhance directivity via its phase-equalization effect on the c-mode and /spl pi/-modes. The realization of air-bridges follows a standard MMIC fabrication process. An experimental chip fabricated on the 75-/spl mu/m GaAs substrate verifies the air-bridge effect and shows wideband characteristics of the coupling of 3.2/spl plusmn/0.4 dB, the insertion loss of 3.9/spl plusmn/0.4 dB, the output phase deviation from quadrature less than 6/spl deg/, and the isolation greater than 18 dB from 20 to 40 GHz.     

Test data compression and test time reduction using an embedded microprocessor

Systems-on-a-chip (SOCs) with many complex intellectual property cores require a large volume of data for manufacturing test. The computing power of the embedded processor in a SOC can be used to test the cores within the chip boundary, reducing the test time and memory requirements. This paper discusses techniques that use the computing power of the embedded processor in a more sophisticated way. The processor can generate and reuse random numbers to construct test patterns and selectively apply only those patterns that contribute to the fault coverage, significantly reducing the pattern generation time, the total number of test applications and, hence, the test time. It can also apply deterministic test patterns that have been compressed using the characteristics of the random patterns as well as those of the deterministic patterns themselves, which leads to high compression of test data. We compare three fast run-length coding schemes which are easily implemented and effective for test-data compression. We also demonstrate the effectiveness of the proposed approach by applying it to some benchmark circuits and by comparing it with other available techniques.     

A graphic approach to performance analysis of multistage linear interference canceller in long-code CDMA systems

The signal-to-interference-plus-noise-ratio performance of the multistage linear parallel and successive interference cancellers (LPIC and LSIC) in a long-code code-division multiple-access system is analyzed using a graphical approach. The decision statistic is modeled as a Gaussian random variable, whose mean and variance can be expressed as functions of moments of R for the LPIC and L for the LSIC, respectively, where R is the correlation matrix of signature sequences and L is the strict lower triangular part of R. Since the complexity of calculating these moments increases rapidly with the growth of the stage index, a graphical representation of moments is developed to facilitate the computation. Propositions are presented to relate the moment calculation problem to several well-known problems in graph theory, i.e., the coloring, the graph decomposition, the biconnected component finding, and the Euler tour problems. It is shown that the derived analytic results match well with simulation results.     

复合材料压缩破坏模式的缺陷敏感性

本文基于弹塑性分叉理论研究单向纤维增强复合材料的压缩破坏模式和压缩强度对缺陷的敏感性问题。对于常见复合材料,所得结论是:无缺陷或者小缺陷情况的破坏模式为倾斜破坏带;大缺陷情况的破坏模式为水平破坏带;形成水平破坏带的压力值小于形成倾斜破坏带的压力。     

Output probability from a general combinational network

In this paper, we present the method which calculates the probability of the output of a general combinational network being 1, when the probabilities is given for each input being 1. Also we present the method which derives the output probability expression in terms of a given set of input probabilities.The method is based on a basic probability axiom and Binary Decision Diagrams. A Boolean function for a combinational network is transformed into a Binary Decision Diagram and the output probability expression is derived from it. Therefore a derivation of the output probability for a combinational network can be straightforward. Some examples are showed that the method using Binary Decision Diagrams is simple and efficient. We can see a variation of the output probability for a combinational network according to the given set of input probabilities.