Investigation of multiple solutions for gas cooled current leads and results of survey information on current leads

This paper is divided into two distinct sections. In the first section, we investigate the possible existence of multiple steady state solutions for a gas cooled lead. In the second section, we summarize calculated values of the runaway and recovery times for 31 current leads in use throughout the world.     

Effect of Aqueous Film Coating Conditions on Water Removal Efficiency and Physical Properties of Coated Tablet Cores Containing Superdisintegrants

Few studies have examined the effect of aqueous film coating process conditions on the physical integrity of the final coated product. Characterization of the aqueous film coating process was previously carried out by selecting water removal efficiency as the response variable to detect and monitor moisture accumulation in the tablet bed [1]. In this study, regression techniques were utilized to obtain the relationship between some physical characteristics of aqueous film coated tablet cores that contained superdisintegrant and several process parameters such as inlet air temperature, spray rate, and pan speed. Tablet response variables measured included residual moisture content, tensile strength and percent porosity. Predicted values of these properties were plotted as a function of the inlet air temperature and the coating solution spray rate. The correlations between the coated tablet response variables and the water removal efficiency of the coating process indicated that coated tablet properties such as residual moisture content, tensile strength, and porosity were linearly correlated with the water removal efficiency of the coating process, which is indicative of the environmental coating conditions present in the coating pan.     

The swelling of core tablets during aqueous coating II: An application of the model describing extent of swelling and water penetration for insoluble tablets

A mathematical model successfully describing the extent of swelling and water penetration for dicalcium phosphate dihydrate(Ditab) tablets is able to be applied to the anhydrous form. The extent of swelling/water penetration behavior exhibited by anhydrous dicalcium phosphate(ATAB) is quite different from that of dihydrate form, which exhibits non-swelling. More water tends to penetrate into ATAB tablets than those tablets prepared from Ditab. The water uptake is coincident to the very large surface tablet porosity.     

The effect of Mill Variables on a Granulation Milling Process

An instrumented mill was used to evaluate the milling of a pharmaceutical granulation. The effects of changing mill speed, screen hole size, impeller type, and impeller-screen clearance on milling time and work, as well as particle size reduction were investigated. Screen hole size had the largest effect on milling time and work as well as particle size reduction, while impeller type had the largest effect on overall milling performance. A new impeller design was tested and found to enhance milling efficiency by improving both particle size reduction and mill output rate.     

Cocaine decreases cortical cerebral blood flow but does not obscure regional activation in functional magnetic resonance imaging in human subjects

The authors used functional magnetic resonance imaging (fMRI) to determine whether acute intravenous (i.v.) cocaine use would change global cerebral blood flow (CBF) or visual stimulation-induced functional activation. They used flow-sensitive alternating inversion recovery (FAIR) scan sequences to measure CBF and blood oxygen level-dependent (BOLD) sensitive T2* scan sequences during visual stimulation to measure neuronal activation before and after cocaine and saline infusions. Cocaine (0.6 mg/kg i.v. over 30 seconds) increased heart rate and mean blood pressure and decreased end tidal carbon dioxide (CO2). All measures returned to baseline by 2 hours, the interinfusion interval, and were unchanged by saline. Flow-sensitive alternating inversion recovery imaging demonstrated that cortical gray matter CBF was unchanged after saline infusion (-2.4 +/- 6.5%) but decreased (-14.1 +/- 8.5%) after cocaine infusion (n = 8, P < 0.01). No decreases were detected in white matter, nor were changes found comparing BOLD signal intensity in cortical gray matter immediately before cocaine infusion with that measured 10 minutes after infusion. Visual stimulation resulted in comparable BOLD signal increases in visual cortex in all conditions (before and after cocaine and saline infusion). Despite a small (14%) but significant decrease in global cortical gray matter CBF after acute cocaine infusion, specific regional increases in BOLD imaging, mediated by neurons, can be measured reliably.     

The Role of Liquid Water Uptake by an Insoluble Tablet Containing a Disintegrant

The hydration capacity of each of four disintegrants including microcrystalline cellulose (Avicel PH102), corn starch, croscarmellose sodium (Ac-di-sol) and sodium starch glycolate (Primojel) was determined to express the hydrophilicity. The complete pore structure, and the water uptake of unmilled dicalcium phosphate dihydrate (Di-Tab) tablets containing one of above disintegrants at 15% w/w level were studied It was found that the majority of the tablet porosity was made up by macropores which were accessed by mercury intrusion There was no statistically significant difference among pore volume-size distributions of table samples The water uptake results were treated by the empirical form of Washburn liquid penetration equation with appropriate experimental setup. It was possible to determine the significance of the empirical parameters drawn from the equation It was found that the hydrophilic nature of excipients present in a tablet played a major role in water uptake phenomenon It was suggested that the disintegrant swelling narrowed the pore sizes in the beginning and then the pores were widened due to the repelling pressure exerted causing the tablet to collapse which made the amount of liquid uptake actually smaller in the beginning and then greater later. Finally, the water penetration is impeded by gelling formation of a disintegrant present in a tablet matrix     

What does Goodfellow's classic analysis tell researchers today?

Discusses the significance of L. D. Goodfellow's (see record 1939-01413-001) interpretation of the Zenith Radio experiments in telepathy. Goodfellow provided a model for critiquing anomalous findings and paranormal claims, stimulated later statistical developments, and anticipated research on sequential patterns in guessing behavior and on contemporary work in cognitive biases. (PsycINFO Database Record (c) 2010 APA, all rights reserved)