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91.
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93.
Youri Oh Hoyong Jung Hyejin Kim Jihyun Baek Joonhong Jun Hyunwook Cho Daseul Im Jung-Mi Hah 《International journal of molecular sciences》2021,22(8)
Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective PLK1 inhibitors, we performed QSAR studies of two series of known PLK1 inhibitors and proposed a new structure based on a hybridized 3D-QSAR model. Given the hybridized 3D-QSAR models, we designed and synthesized 4-benzyloxy-1-(2-arylaminopyridin-4-yl)-1H-pyrazole-3-carboxamides, and we inspected its inhibitory activities to identify novel PLK1 inhibitors with decent potency and selectivity. 相似文献
94.
Gwan Hee Han Ilseon Hwang Hanbyoul Cho Kris Ylaya Jung-A Choi Hyunja Kwon Joon-Yong Chung Stephen M. Hewitt Jae-Hoon Kim 《International journal of molecular sciences》2021,22(11)
Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes in tumors. Specifically, the presence of specific tumor-infiltrating lymphocytes (TILs) with particular hormone receptor expression is reportedly associated with breast cancer, however, this has not been revealed in epithelial ovarian cancer (EOC). Therefore, we investigated the association between hormone receptor expression and TILs in EOC. Here we found that ERα, AR, and GR expression increased in EOC, while PR was significantly reduced and ERβ expression showed a reduced trend compared to normal epithelium. Cluster analysis indicated poor disease-free survival (DFS) in AR+/GR+/PR+ subgroup (triple dominant group); while the Cox proportional-hazards model highlighted the triple dominant group as an independent prognostic factor for DFS. In addition, significant upregulation of FoxP3+ TILs, PD-1, and PD-L1 was observed in the triple dominant group compared to other groups. NanoString analyses further suggested that tumor necrosis factor (TNF) and/or NF-κB signaling pathways were activated with significant upregulation of RELA, MAP3K5, TNFAIP3, BCL2L1, RIPK1, TRAF2, PARP1, and AKT1 in the triple dominant EOC group. The triple dominant subgroup correlates with poor prognosis in EOC. Moreover, the TNF and/or NF-κB signaling pathways may be responsible for hormone-mediated inhibition of the immune microenvironment. 相似文献
95.
Jinhong Kim Junho Jang Sehui Yun Hyeon Deok Kim You Young Byun Yong Tae Park Jung Il Song Chungyeon Cho 《大分子材料与工程》2021,306(9):2100233
In an effort to develop highly functionalized flame retardant materials, hybrid nanocoatings are prepared by alternately depositing a positively charged polyaniline (PANi) and negatively charged montmorillonite (MMT) using the layer-by-layer (LbL) assembly technique. Carbon nanotubes (CNTs) are employed in polymer nanocomposites as effective reinforcement, where nanotubes are stabilized in MMT aqueous solution. The 3D structure and high density of CNTs deposited in the PANi/CNTs-MMT multilayers produce thicker and heavier coatings in comparison to the LbL assemblies without CNTs. Vertical and horizontal flame testing show that the incorporation of CNTs improves fire resistance. Additionally, cone calorimetry reveals that stacking two nanomaterials (MMT and CNTs) in a single coating shows a significant reduction in peak heat release rate (up to 51%), total smoke release (up to 47%), and total heat release (up to 37%) for the polyurethane foam. The enhancement of flame retardancy is attributed to a synergistic effect; MMT serves as a physical barrier that retards the diffusion of heat and gas. The addition of CNTs strengthens the thermal stability and high char yield. These results, coupled with the simplicity with which the LbL deposition is applied, present a viable alternative to halogen-free flame retardant nanocoatings to natural and synthetic fibers. 相似文献
96.
Marine antifouling coating using functional polymers has emerged as an important tool to combat marine fouling. Owing to their natural abundance, polysaccharides represent a more sustainable option than synthetic polymers and carrageenan, a sulfated polysaccharide, is identified as a promising candidate for further research based on its excellent marine antifouling properties. However, existing research has only explored the application of carrageenan-based coatings for 2D objects, using techniques such as spin-coating. Here, a spray-coating method is proposed to apply carrageenan-based coatings to the surfaces of 2- and 3-D objects. The coated surfaces exhibit high stability under various chemical/physical stresses and high resistance to protein adsorption and marine diatom adhesion. 相似文献
97.
Koo Hyun Lee Ki Suk Nam Youl Min Park Pyung Woo Shin Deuk Yong Lee Yo-Seung Song 《Metals and Materials International》2002,8(4):381-385
Plasma nitrocarburized AISI 1020 steels were oxidized for 15, 30 and 60 min to evaluate their corrosion and microstructural properties. After plasma nitrocarburizing for 3 h at 570°C in a gas mixture comprising 85 vol.% N2, 12vol.% H2 and 3 vol.% CH4, the compound layer composed of ɛ-Fe2–3(N,C) and γ’-Fe4(N,C) phases and the diffusion layer above the matrix were observed. The top oxide layer, consisting mainly of magnetite (Fe2O4) and hematite (Fe2O3) phases, forms after post-oxidation treatment at 500°C. However, the oxide layer was severely degraded by spallation as a result of increases in post-oxidizing time. The difference in corrosion resistance should be attributed to the thickness of the top oxide layer, which was governed by post-oxidizing time. 相似文献
98.
Seung Beom Cho Sridhar Venigalla James H. Adair † 《Journal of the American Ceramic Society》1996,79(1):88-96
Phase-pure, monodispersed, hexagonal plates of single-crystal α-alumina (∼ 2 μm wide and ∼0.5 μm thick) have been prepared via precipitation by treating an aluminum hydrous oxide precursor in 1,4-butanediol at 300°C under autogenous vapor pressure. Present work shows that KOH is the only reagent that precipitates an aluminum hydrous oxide precursor suitable to synthesize α-alumina in 1,4-butanediol solution. In contrast, the use of NaOH or NH4 OH as the precipitating reagent for the precursor material does not yield the alpha phase. The solution pH at which the precursor materials are precipitated is also a critical factor for the formation of α-Al2 O3 . Phase-pure α-alumina powders were also only synthesized from the aluminum hydrous oxide precursors precipitated in the pH range from 10 to 10.5. The results of X-ray diffraction and scanning electron microscopy indicate that longer reaction times promote the phase transformation from the intermediate boehmite phase to α-alumina. The complete transformation from boehmite to α-alumina requires reaction times of about 12 h. 相似文献
99.
It has been reported that for polymer blends with high viscosity ratio (>1), the size of the dispersed particles decreases with increasing volume fraction of the dispersed phase. In order to explain this effect, an equation was derived for the affine deformation of an imaginary plane of the dispersed phase in stratified two‐phase steady, simple, shear flow. The model predicts that for viscosity ratio >1, the deformation rate increases with volume fraction of the dispersed phase, and the shear stress also increases, leading to an increase of the breakup time. Therefore, the total deformation of the dispersed phase, before breakup, increases with increase of volume fraction, resulting in a decrease of the size of the dispersed phase particles. Accordingly, one can expect that in industrial mixers, the particle size of the blends should decrease as the volume fraction increases, if coalescence is suppressed. Experiments were carried out in a Haake batch mixer, using polyethylene/polyamide‐6 blends compatibilized by adding maleic anhydride grafted polyethylene. Particle size decreased up to 20 wt% polyamide‐6, at 100, 150, and 200 RPM, and increased between 20 and 30 wt%. The decrease of the particle size is mainly due to increased deformation of the dispersed phase. The increase of the particle size above 20 wt% is due to coalescence at high fractions. 相似文献
100.
Dong Won Cho Young Hae Lee Tae Youn Lee Mitsuo Gen 《Journal of Intelligent Manufacturing》2014,25(5):1025-1042
In this paper we propose an adaptive genetic algorithm that produces good quality solutions to the time dependent inventory routing problem (TDIRP) in which inventory control and time dependent vehicle routing decisions for a set of retailers are made simultaneously over a specific planning horizon. This work is motivated by the effect of dynamic traffic conditions in an urban context and the resulting inventory and transportation costs. We provide a mixed integer programming formulation for TDIRP. Since finding the optimal solutions for TDIRP is a NP-hard problem, an adaptive genetic algorithm is applied. We develop new genetic representation and design suitable crossover and mutation operators for the improvement phase. We use adaptive genetic operator proposed by Yun and Gen (Fuzzy Optim Decis Mak 2(2):161–175, 2003) for the automatic setting of the genetic parameter values. The comparison of results shows the significance of the designed AGA and demonstrates the capability of reaching solutions within 0.5 % of the optimum on sets of test problems. 相似文献