Predictable and unpredictable shock: Behavioral measures of aversion and physiological measures of stress.

Reviews the literature on predictable and unpredictable shock conditions relative to physiological measures of stressfulness and considers the possible role of stress-induced analgesia in both physiological and behavioral effects. Findings suggest that unpredictable conditions are physiologically more stressful than predictable conditions when Ss are exposed to them for one or a few sessions and when parameters of stress are relatively severe. However, predictable conditions may be more stressful than unpredictable conditions when sessions are long and extend over days and when parameters of stress are less severe. The effect of extended stress appears to depend on the physiological measure used. These findings are discussed in terms of the phasic vs chronic nature of predictable vs unpredictable stress and the organism's ability to adapt physiologically to these conditions. Data on stress-induced analgesia are also reviewed. It is concluded that stress-induced analgesia does not significantly contribute to either preference for predictable over unpredictable stress or to their differential physiological effects. (88 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On a sequential search strategy in global optimization problems

A class of sequential strategies for finding the global maximum of a real valued function is developed following a multistep optimality scheme. A new criterion is shown to give an optimal choice of each sequential step of the algorithm; numerical evidence is eventually reported which confirms the theoretical indications.     

让错误无可遁形

多年来，很多媒体都报道了工业图像识别系统在不同场合的应用，尤其在与图像密切相关的领域——印刷行业的应用。然而，事实上，工业图像识别系统却始终没有在印刷行业得到普遍应用。     

Evaluation and implementation of a system to eliminate arbitraryload effects in current-based monitoring of induction machines

This paper presents a method for removing the load effects from the monitored quantity of the machine. Fault conditions in induction machines cause the magnetic field in the airgap of the machine to be nonuniform. This results in harmonics in the stator current of the motor which can be measured in order to determine the health of the motor. However, variations in the load torque which are not related to the health of the machine typically have exactly the same effect on the load current. Previously presented schemes for current-based condition monitoring ignore the load effect or assume it is known. Therefore, a scheme for determining machine health in the presence of a varying load torque requires some method for separating the two effects. This is accomplished by comparing the actual stator current to a model reference value which includes the load effects. The difference between these two signals provides a filtered quantity, independent of variations of the load, that allows continuous on-line condition monitoring to be conducted without concern for the load condition. Simulation and test results illustrate the effects on the spectrum of the monitored quantity for both constant and eccentric airgaps when in the presence of an oscillating load     

New,Non‐quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90

Streptomyces hygroscopicus is a natural producer of geldanamycin. Mutasynthetic supplementation of an AHBA‐blocked mutant with all possible monofluoro 3‐aminobenzoic acids provided new fluorogeldanamycins. These showed strong antiproliferative activity and inhibitory effects on human heat shock protein Hsp90. Binding to Hsp90 in the low nanomolar range was determined from molecular modelling, AFM analysis and by calorimetric studies.     

Bayesian model for flow-class dependent distributions of fecal-indicator bacterial concentration in surface waters

A Bayesian statistical water quality model is demonstrated to predict fecal-indicator bacterial concentrations for waterbodies without sufficient monitoring data for data-intensive modeling techniques. Using a truncated bivariate normal likelihood function and the readily available observations of flow and bacterial concentration, the Bayesian approach propagates the uncertainty in the model parameterization to the final predictions of in-stream bacterial concentration. The proposed model captures the variation in the magnitude of bacterial loading between dry and wet conditions by estimating separate sets of model parameters for different flow conditions, but also has the capability to pool the data among flow conditions. The model can be used in two ways: first, the model specifies the percent of time that the recreational season in-stream concentration is not in compliance with the relevant water quality standard, and second, the model estimates the necessary bacterial load reduction for multiple flow conditions to meet the relevant water quality standard. Using an eleven year monitoring record for a site sampled at a monthly frequency on the Youghiogheny River in southwestern Pennsylvania, USA, the model parameters are updated and posterior predictions are generated for each 2-year increment. After six years of sampling, the predicted percent of time that the recreational season in-stream bacterial concentration is not in compliance with the relevant water quality is 82% with 95% CI(80,85), and the bacterial load reductions required to meet the standard are 14.7 CI(14.6,14.8), 14.5 CI(14.3, 14.6), and 14.0 CI(13.9, 14.2) log₁₀(cfu/day) for the high, normal, and dry flow conditions, respectively. The change in estimated load reduction and percent exceedance resulting from additional monitoring for this site becomes small after six years of sampling, indicating that a decision does not need to be postponed for additional monitoring.     

The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis

The etiology of atherosclerosis is complex and multifactorial but there is extensive evidence indicating that oxidized lipoproteins may play a key role. At present, the site and mechanism by which lipoproteins are oxidized are not resolved, and it is not clear if oxidized lipoproteins form locally in the artery wall and/or are sequestered in atherosclerotic lesions following the uptake of circulating oxidized lipoproteins. We have been focusing our studies on demonstrating that such potentially atherogenic oxidized lipoproteins in the circulation are at least partially derived from oxidized lipids in the diet. Thus, the purpose of our work has been to determine in humans whether oxidized dietary oxidized fats such as oxidized fatty acids and oxidized cholesterol are absorbed and contribute to the pool of oxidized lipids in circulating lipoproteins. When a meal containing oxidized linoleic acid was fed to normal subjects, oxidized fatty acids were found only in the postprandial chylomicron/chylomicron remnants (CM/RM) which were cleared from circulation within 8 h. No oxidized fatty acids were detected in low density lipoprotein (LDL) or high density lipoprotein (HDL) fractions at any time. However, when alpha-epoxy cholesterol was fed to human subjects, alpha-epoxy cholesterol in serum was found in CM/RM and also in endogenous very low density lipoprotein, LDL, and HDL and remained in the circulation for 72 h. In vitro incubation of the CM/RM fraction containing alpha-epoxy cholesterol with human LDL and HDL that did not contain alpha-epoxy cholesterol resulted in a rapid transfer of oxidized cholesterol from CM/RM to both LDL and HDL. We have suggested that cholesteryl ester transfer protein is mediating the transfer. Thus, alpha-epoxy cholesterol in the diet is incorporated into CM/RM fraction and then transferred to LDL and HDL contributing to lipoprotein oxidation. We hypothesize that diet-derived oxidized fatty acids in chylomicron remnants and oxidized cholesterol in remnants and LDL accelerate atherosclerosis by increasing oxidized lipid levels in circulating LDL and chylomicron remnants. This hypothesis is supported by our feeding experiments in animals. When rabbits were fed oxidized fatty acids or oxidized cholesterol, the fatty streak lesions in the aorta were increased by 100%. Moreover, dietary oxidized cholesterol significantly increased aortic lesions in apo-E and LDL receptor-deficient mice. A typical Western diet is rich in oxidized fats and therefore could contribute to the increased arterial atherosclerosis in our population.