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21.
Tariq Mahmood Syed Imran Jami Zubair Ahmed Shaikh Muhammad Hussain Mughal 《Computer Standards & Interfaces》2013,35(1):6-29
In this paper, we implement a provenance-aware system for documenting publications, called PADS. It employs a three-layered provenance hierarchy, which can output diverse types of provenance data related to the research life cycle. From this, we generate different profiles for research ventures, reviewers, and authors. PADS employs the standard Open Provenance Model (OPM) specification for capturing provenance data, and stores this data as ontological instances. We show that data is retrieved without any apparent delay in the execution time of the queries. We also demonstrate how this data can be used to make useful recommendations to the organizers, in order to manage upcoming research ventures. 相似文献
22.
Rabia Rasool Inam Ullah Bismillah Mubeen Sultan Alshehri Syed Sarim Imam Mohammed M. Ghoneim Sami I. Alzarea Fahad A. Al-Abbasi Bibi Nazia Murtaza Imran Kazmi Muhammad Shahid Nadeem 《International journal of molecular sciences》2022,23(3)
Breast cancer is a diverse disease caused by mutations in multiple genes accompanying epigenetic aberrations of hazardous genes and protein pathways, which distress tumor-suppressor genes and the expression of oncogenes. Alteration in any of the several physiological mechanisms such as cell cycle checkpoints, DNA repair machinery, mitotic checkpoints, and telomere maintenance results in genomic instability. Theranostic has the potential to foretell and estimate therapy response, contributing a valuable opportunity to modify the ongoing treatments and has developed new treatment strategies in a personalized manner. “Omics” technologies play a key role while studying genomic instability in breast cancer, and broadly include various aspects of proteomics, genomics, metabolomics, and tumor grading. Certain computational techniques have been designed to facilitate the early diagnosis of cancer and predict disease-specific therapies, which can produce many effective results. Several diverse tools are used to investigate genomic instability and underlying mechanisms. The current review aimed to explore the genomic landscape, tumor heterogeneity, and possible mechanisms of genomic instability involved in initiating breast cancer. We also discuss the implications of computational biology regarding mutational and pathway analyses, identification of prognostic markers, and the development of strategies for precision medicine. We also review different technologies required for the investigation of genomic instability in breast cancer cells, including recent therapeutic and preventive advances in breast cancer. 相似文献
23.
Martina Casarin Tiago Moderno Fortunato Saima Imran Martina Todesco Deborah Sandrin Giulia Borile Ilaria Toniolo Massimo Marchesan Gino Gerosa Andrea Bagno Filippo Romanato Emanuele Luigi Carniel Alessandro Morlacco Fabrizio Dal Moro 《International journal of molecular sciences》2022,23(5)
Bladder cancer (BC) is among the most common malignancies in the world and a relevant cause of cancer mortality. BC is one of the most frequent causes for bladder removal through radical cystectomy, the gold-standard treatment for localized muscle-invasive and some cases of high-risk, non-muscle-invasive bladder cancer. In order to restore urinary functionality, an autologous intestinal segment has to be used to create a urinary diversion. However, several complications are associated with bowel-tract removal, affecting patients’ quality of life. The present study project aims to develop a bio-engineered material to simplify this surgical procedure, avoiding related surgical complications and improving patients’ quality of life. The main novelty of such a therapeutic approach is the decellularization of a porcine small intestinal submucosa (SIS) conduit to replace the autologous intestinal segment currently used as urinary diversion after radical cystectomy, while avoiding an immune rejection. Here, we performed a preliminary evaluation of this acellular product by developing a novel decellularization process based on an environmentally friendly, mild detergent, i.e., Tergitol, to replace the recently declared toxic Triton X-100. Treatment efficacy was evaluated through histology, DNA, hydroxyproline and elastin quantification, mechanical and insufflation tests, two-photon microscopy, FTIR analysis, and cytocompatibility tests. The optimized decellularization protocol is effective in removing cells, including DNA content, from the porcine SIS, while preserving the integrity of the extracellular matrix despite an increase in stiffness. An effective sterilization protocol was found, and cytocompatibility of treated SIS was demonstrated from day 1 to day 7, during which human fibroblasts were able to increase in number and strongly organize along tissue fibres. Taken together, this in vitro study suggests that SIS is a suitable candidate for use in urinary diversions in place of autologous intestinal segments, considering the optimal results of decellularization and cell proliferation. Further efforts should be undertaken in order to improve SIS conduit patency and impermeability to realize a future viable substitute. 相似文献
24.
M. A. Khattak Anique Mukhtar Imran S. S. Ghumman Miraj Muhammad Jan 《Journal of Failure Analysis and Prevention》2018,18(2):274-279
Pressure cooker is a closed domestic pressure cooking vessel for use with external heat source and capable of maintaining nominal cooking pressure up to 1.0 kgf/cm2 (100 kN/m2 approximately) gauge nominal. In pressure cookers, despite the development of electronic controllers, the basic edition of such vessels are still equipped with fewer advanced safety functions due to economic constraints. Although the provision of pressure relief valves (PRV) is considered as one of the major protective features, however, pressure cooker failure accidents have been reported frequently. This paper describes the analysis of pressure cooker failure that failed prematurely after 1 year of service considering the design life of > 5 years. It was hypothesized that the root cause of pipe failure was either material degradation from exposure to an aggressive environment or an inherent defect in the pressure cooker. To test this hypothesis, a thorough visual examination of the exhumed failed section and the fracture surface was undertaken, followed by liquid penetrant testing, material identification, hardness testing, and metallographic analysis. Computational models of static and transient loading were also used to determine the stress distribution along the actual geometry of the failed cooker and to understand the main causes of recurrent failures. Visual and macroscale examination revealed significant body deformation at the lower dish-ended shell showing distorted locking grooves. It was also noticed that dirt and food particle, from the earlier cooking, were stuck in the pressure valves orifice. In addition, no evidence of metallurgical defect was observed. The inspection indicated that the cause of failure is primarily due to the choking of pressure relief value (PRV) and overpressure safety valves. Consequently, the pressure release occurred from the sealing side of the top lid, which resulted in its ejection. 相似文献
25.
Ahmad Awais Ahmad Mudassar Habib Muhammad Asif Sarwar Shahzad Chaudhry Junaid Latif Muhammad Ahsan Dar Saadat Hanif Shahid Muhammad 《The Journal of supercomputing》2019,75(4):2269-2288
The Journal of Supercomputing - The main challenge in database-as-a-service is the security and privacy of data because service providers are not usually considered as trustworthy. So, the data... 相似文献
26.
Sarwar Sohail Qayyum Zia Ul García-Castro Raúl Safyan Muhammad Munir Rana Faisal 《Multimedia Tools and Applications》2019,78(24):34745-34771
Multimedia Tools and Applications - Enhancing the degree of learner productivity, one of the major challenges in E-Learning systems, may be catered through effective personalization, adaptivity and... 相似文献
27.
Khan Muhammad Imran Dong Huang Shabbir Faisal Shoukat Rizwan 《Microsystem Technologies》2018,24(2):869-877
Microsystem Technologies - Electronic devices are shrinking day by day, while the speed and reliability is increasing. At the same time, IC designs and micro/nano electronic systems are becoming... 相似文献
28.
Microsystem Technologies - The objective of this research paper is to find the way to guide the worms in an electric field gradient for a specific time period. Research has been done to guide the... 相似文献
29.
Telecommunication Systems - Low powered node densification leading to dense and ultra dense heterogeneous networks is a feature of 5th generation cellular networks. With this densification, the... 相似文献
30.
Tanoli Shujaat Ali Khan Mustafa Ali Nawaz Faiza Khan Imran Usman Muhammad Khan Zuhaib Ashfaq 《Wireless Networks》2019,25(8):5045-5056
Wireless Networks - This research article presents an innovative approach based on analog network coding (ANC) in conjunction with space time block coding (STBC) which is termed as space time... 相似文献