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71.
Strength distributions and size effects for 2D and 3D composites with Weibull fibers in an elastic matrix 总被引:1,自引:0,他引:1
Sivasambu Mahesh S. Leigh Phoenix Irene J. Beyerlein 《International Journal of Fracture》2002,115(1):41-85
Monte Carlo simulation and theoretical modeling are used to study the statistical failure modes in unidirectional composites consisting of elastic fibers in an elastic matrix. Both linear and hexagonal fiber arrays are considered, forming 2D and 3D composites, respectively. Failure is idealized using the chain-of-bundles model in terms of -bundles of length , which is the length-scale of fiber load transfer. Within each -bundle, fiber load redistribution is determined by local load-sharing models that approximate the in-plane fiber load redistribution from planar break clusters, as predicted from 2D and 3D shear-lag models. As a result the -bundle failure models are 1D and 2D, respectively. Fiber elements have random strengths following either a Weibull or a power-law distribution with shape and scale parameters and , respectively. Under Weibull fiber strength, failure simulations for 2D -bundles, reveal two regimes: When fiber strength variability is low (roughly >2) the dominant failure mode is by growing clusters of fiber breaks, one of which becomes catastrophic. When this variability is high (roughly 0<<2) cluster formation is suppressed by a dispersed failure mode due to the blocking effects of a few strong fibers. For 1D -bundles or for 2D -bundles under power-law fiber strength, the transitional value of drops to 1 or lower, and overall, it may slowly decrease with increasing bundle size. For the two regimes, closed-form approximations to the distribution of -bundle strength are developed under the local load-sharing model and an equal load-sharing model of Daniels, respectively. The results compare favorably with simulations on -bundles with up to 1500 fibers. 相似文献
72.
A three-stage continuous culture system was used to segregate the component microbial groups of a methanogenic hexanoate-degrading association enriched from anaerobic refuse. The inhibitory effects of o-cresol concentrations (2-20 mM) on the fermentative, acetogenic, sulphate-reducing and methanogenic bacteria were then assessed in the presence of either 1.4 or 3.5 mM sulphate in the influent medium. The sulphate-reducing bacteria (SRB) in the 1.4 mM sulphate-supplemented systems were the most sensitive to o-cresol, with 29.3 and 56.6% inhibition on supplementation with 4 and 6 mM o-cresol, respectively. With 3.5mM supplementation, inhibition was 4.5 and 19.4%, respectively. Methanogenesis was not inhibited by concentrations < 10 mM o-cresol, and complete inhibition was recorded only at concentrations > or = 10 mM. Both fermentation and acetogenesis were affected by inhibition of the electron sinks. The increase in influent sulphate concentration promoted electron flow to sulphidogenesis, as predicted on thermodynamic criteria, but did not affect the relative sensitivity of the different physiological groups. 相似文献
73.
Identification of potent human anti-IL-1RI antagonist antibodies 总被引:4,自引:0,他引:4
Fredericks ZL Forte C Capuano IV Zhou H Vanden Bos T Carter P 《Protein engineering, design & selection : PEDS》2004,17(1):95-106
Interleukin-1 (IL-1) blockade by IL-1 receptor antagonist benefits some arthritis patients by reducing joint damage. This fact inspired us to develop antagonist human therapeutic antibodies against IL-1R(I) using phage libraries that display single-chain variable fragment (scFv) antibody fragments. Panning libraries against human IL-1R(I) generated 39 unique scFv-phage whose binding to IL-1R(I) was competed by IL-1 ligands. Fifteen of these scFv-phage, identified using IL-1R(I)-binding assays and dissociation rate ranking, were reformatted as scFv-Fc and IgG(4) molecules. The ease of producing antibodies in the scFv-Fc format permitted rapid identification of four lead clones (C10, C13, C14, C15) that inhibit NF-kappaB nuclear translocation induced by IL-1. Reformatting these clones as IgG(4) molecules increased their inhibition potency by =24-fold. C10 IgG(4) is the most potent antagonist of IL-1alpha (26 nM IC(50)) and IL-1beta (18 nM IC(50)) in the NF-kappaB bioassay, although less potent than IL-1ra ( approximately 0.4 nM IC(50)). C10 is the highest affinity clone for human IL-1R(I) (K(D) approximately 60 nM). Flow cytometry indicates that several lead clones bind cell-surface cynomolgus or murine IL-1R(I), characteristics advantageous for preclinical toxicology and efficacy studies. This study demonstrates the utility of scFv-Fc fusion proteins for rapid screening of clones derived from phage libraries to identify antibody leads with therapeutic potential. 相似文献
74.
José?Luis?Pe?alvoEmail author M.?Con?eic?o?Castilho M.?Irene?N.?Silveira M.?Cruz?Matallana M.?Esperanza?Torija 《European Food Research and Technology》2004,219(3):251-253
Soymilk is a water extract of soybeans, closely resembling dairy milk in physical appearance and composition. Most fatty acids in soybean and its derivates are unsaturated, and therefore susceptible to oxidation. The aim of this study was to evaluate the possible effect of the thermal conditions during the elaboration process of soymilk on its fatty acid profile. For this, the fatty acid composition of soymilk, okara (soymilk residue), and soybean were studied by gas chromatography with flame ionization detection (GC-FID). No major differences in the fatty acid patterns were found. 相似文献
75.
Formation of haloacetic acids during monochloramination 总被引:8,自引:0,他引:8
Factors that affect the formation of haloacetic acids (HAAs) during monochloramination, such as monochloramine application techniques, the initial chlorine (Cl) to ammonia-N (N) ratios, the bromide concentrations, and the wastewater quality, were studied. Aqueous humic acid solutions and undisinfected wastewater effluent samples obtained from two Hong Kong Sewage Treatment Works (STWs) were monochloraminated under various conditions. HAA formation was strongly affected by the monochloramine application techniques. The formation of trichloroacetic acid (TCAA) and total HAAs was reduced by adding preformed monochloramine. A higher initial Cl:N ratio indicated a higher chlorine demand and consequently led to higher HAA yields. Increasing the bromide concentration shifted HAAs from chlorinated species to brominated species and increased the yields of total HAAs, concurrent with decreases in the yields of dichloroacetic acid (DCAA) and TCAA but with increases in those of the other HAAs measured. Variations in the patterns of HAA formation were observed in monochloraminated wastewater effluent samples. The variations cannot be simply explained by the chlorine chemistry involving ammonia and/or bromide but are likely attributable to the combining effects of the water quality and the characteristics of the organics in the wastewater. 相似文献
76.
Irene Mavrommati Achilles Kameas Panos Markopoulos 《Personal and Ubiquitous Computing》2004,8(3-4):255-263
The forthcoming home environment will comprise numerous computationally enhanced artifacts that are autonomous, but interconnected via an invisible web of network-based services. The approach presented in this paper is to enable end users to make their own applications by linking such artifacts, which are treated as reusable components. A key requirement to achieve this is the availability of editing tools that meet the needs of different classes of users. A tool of this kind designed for end users is presented in this paper, together with the outcome of user evaluation sessions. 相似文献
77.
Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil 总被引:7,自引:0,他引:7
Golet EM Xifra I Siegrist H Alder AC Giger W 《Environmental science & technology》2003,37(15):3243-3249
The behavior of fluoroquinolone antibacterial agents (FQs) during mechanical-biological wastewater treatment was studied by mass flow analysis. In addition, the fate of FQs in agricultural soils after sludge application was investigated. Concentrations of FQs in filtered wastewater (raw sewage, primary, secondary, and tertiary effluents) were determined using solid-phase extraction with mixed phase cation exchange disk cartridges and reversed-phase liquid chromatography with fluorescence detection. FQs in suspended solids, sewage sludge (raw, excess, and anaerobically digested sludge), and sludge-treated soils were determined as described for the aqueous samples but preceded by accelerated solvent extraction. Wastewater treatment resulted in a reduction of the FQ mass flow of 88-92%, mainly due to sorption on sewage sludge. A sludge-wastewater partition coefficient (log Kd approximately 4) was calculated in the activated sludge reactors with a hydraulic residence time of about 8 h. No significant removal of FQs occurred under methanogenic conditions of the sludge digesters. These results suggest sewage sludge as the main reservoir of FQ residues and outline the importance of sludge management strategies to determine whether most of the human-excreted FQs enter the environment. Field experiments of sludge-application to agricultural land confirmed the long-term persistence of trace amounts of FQs in sludge-treated soils and indicated a limited mobility of FQs into the subsoil. 相似文献
78.
Escaja N Gómez-Pinto I Rico M Pedroso E González C 《Chembiochem : a European journal of chemical biology》2003,4(7):623-632
The structures and stabilities of cyclic DNA octamers of different sequences have been studied by NMR and CD spectroscopy and by restrained molecular dynamics. At low oligonucleotide concentrations, some of these molecules form stable monomeric structures consisting of a short stem of two base pairs connected by two mini-loops of two residues. To our knowledge, these dumbbell-like structures are the smallest observed to date. The relative stabilities of these cyclic dumbbells have been established by studying their melting transitions. Dumbbells made up purely of GC stems are more stable than those consisting purely of AT base pairs. The order of the base pairs closing the loops also has an important effect on the stabilities of these structures. The NMR data indicate that there are significant differences between the solution structures of dumbbells with G-C base pairs in the stem compared to those with A-T base pairs. In the case of dumbbells with G-C base pairs, the residues in the stem form a short segment of a BDNA helix stabilized by two Watson-Crick base pairs. In contrast, in the case of d, the stem is formed by two A-T base pairs with the glycosidic angles of the adenine bases in a syn conformation, most probably forming Hoogsteen base pairs. Although the conformations of the loop residues are not very well defined, the thymine residues at the first position of the loop are observed to fold back into the minor groove of the stem. 相似文献
79.
The effects of the operating conditions, the initial concentrations of marine diesel fuel (MDF) and the coexisting Pb in the soil, and the ethylene diamine tetra acetic salt (EDTA) in solution on MDF removal by sodium dodecyl sulfate (SDS) washing were extensively investigated with the aim of optimizing the process parameters and determining the MDF removal efficiency by SDS under different contamination conditions. The experimental results from batch tests indicated that the majority of MDF was removed by SDS in the first 2?h, and its optimal pH was nearly neutral. Increasing the SDS concentration linearly increased the MDF removal efficiency. At a given SDS concentration, the removal efficiency was dependent on the existing forms of MDF in soils, and the free phase of MDF was found to be more easily removed than the adsorbed phase. MDF removal by SDS was significantly reduced by the coexisting Pb in soils, which likely forms a complexation with SDS and thereby enhances the partitioning of MDF in the soil by the re-adsorption of released MDF onto the hydrophobic tails of the adsorbed SDS. EDTA alone, or with SDS, could remove MDF, but the remaining MDF in the contaminated soil after EDTA washing became more difficult to be removed by SDS. Therefore, the EDTA washing followed by SDS washing is not recommended for MDF removal. 相似文献
80.
Pepperberg Irene M.; Sandefer Robert M.; Noel Dawn A.; Ellsworth Clare P. 《Canadian Metallurgical Quarterly》2000,114(4):371
Grey parrots (Psittacus erithacus) learn referential English labels when they view and interact with 2 humans who model vocal labeling and who demonstrate referentiality and functionality of a label (I. M. Pepperberg, 1990a). To test if both trainers are necessary, the authors contrasted 2-trainer modeling with training by 1 human who presented targeted labels to a bird in concert with appropriate items, who asked questions, and who would reward attempts at the label with the item. The bird was also tutored by either 1 or 2 interactive humans in conjunction with a conspecific who already used referential labels. Referential labels were learned from multiple live tutors but not a single trainer. Presence of a conspecific enhanced learning compared with single-trainer sessions but did not affect acquisition in 2-human sessions. Specific aspects of paired tutoring seem critical for acquiring referential vocal labels. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献