The Co-Sn (Cobalt-Tin) System

This work was supported by the Japanese Committee for Alloy Phase Diagrams. Part of the literature search was provided by ASM International. Literature searched through 1987. Professor Nishizawa is the Alloy Phase Diagram Program Category Editor for binary cobalt alloys     

Monolithic photovoltaic PbS-on-Si infrared-sensor array

The growth of epitaxial narrow-gap PbS-on-Si substrates using a stacked CaF₂-BaF₂ intermediate buffer layer and the fabrication of linear arrays of photovoltaic infrared (IR) sensors in the PbS layer are discussed. The sensors of the array exhibit resistance-area products at zero bias of 3 Ω-cm² at 200 K (3.4-μm cutoff wavelength) and 2×10⁵ Ω-cm ² at 84 K (4-μm cutoff), with corresponding detectivities of 2×10¹⁰ and 1×10¹³ cm-√Hz/W, respectively     

Reconfiguration of Logical Topologies with Minimum Traffic Disruptions in Reliable WDM-Based Mesh Networks

A wavelength division multiplexing (WDM) network offers a flexible networking infrastructure by assigning the route and wavelength of lightpaths. We can construct an optimal logical topology, by properly setting up the lightpaths. Furthermore, setting up a backup lightpath for each lightpath improves network reliability. When traffic demand changes, a new optimal (or sub-optimal) topology should be obtained by again applying the formulation. Then, we can reconfigure the running topology to the logical topology obtained. However, during this reconfiguration, traffic loss may occur due to the deletion of older lightpaths. In this paper, we consider reconfiguring the logical topology in reliable WDM-based mesh networks, and we propose five procedures that can be used to reconfigure a running lightpath to a new one. Applying the procedures one by one produces a new logical topology. The procedures mainly focus on utilizing free wavelength resources and the resources of backup lightpaths, which are not used usually for transporting traffic. The results of computer simulations indicate that the traffic loss is remarkably reduced in the 14-node network we used as an example.     

Anxiety-like behavior in transgenic mice with brain expression of neuropeptide Y

In an attempt to understand the relationship between photorepair and dark repair in Neurospora crassa, a new mutant was isolated, which showed defects in both repair processes. The new mutant, mus-38, is moderately sensitive to UV and shows imperfect photoreactivation following UV irradiation. DNA was purified from this mutant and the other UV-sensitive mutants, and analyzed for the removal of cyclobutane pyrimidine dimers (CPDs). UV-specific endonuclease-sensitive sites (ESS) completely disappeared with 1 h of photoreactivation in mus-38 DNA, although the survival recovery with photoreactivation was greatly reduced in this mutant. This suggests that the insufficient survival recovery with photoreactivation in mus-38 does not result from a failure of photo-reversal of CPDs. Removal of ESS during liquid holding (dark repair) was slower in mus-38 compared to wild type. To test the possibility that this mutant was involved in excision repair, the double mutant was made between mus-38 and mus-18, which encodes a UV-damage-specific endonuclease. CPD excision in the mus-18 null mutant was severely affected but not completely inhibited. The double mutant showed a complete loss of the excision activity and was super sensitive to UV. These results indicate that mus-38 participates in an excision pathway that is different from the mus-18 pathway. The mus-38 mutant was sensitive not only to UV but also to some chemical mutagens which make adducts on DNA. Thus, mus-38 is possibly involved in an excision-repair pathway that is related to the Saccharomyces cerevisiae RAD3 pathway.     

Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets

Crkl, a 39-kD SH2, SH3 domain-containing adapter protein, is constitutively tyrosine phosphorylated in hematopoietic cells from chronic myelogenous leukemia (CML) patients. We recently reported that thrombopoietin induces tyrosine phosphorylation of Crkl in normal platelets. In this study, we demonstrate that thrombopoietin induces association of Crkl with a tyrosine phosphorylated 95- to 100-kD protein in platelets and in UT7/TPO cells, a thrombopoietin-dependent megakaryocytic cell line. With specific antibodies against STAT5, we demonstrate that the 95- to 100-kD protein in Crkl immunoprecipitates is STAT5. This coimmunoprecipitation was specific in that Crkl immunoprecipitates do not contain STAT3, although STAT3 becomes tyrosine phosphorylated in thrombopoietin-stimulated platelets. The coimmunoprecipitaion of Crkl with STAT5 was inhibited by the immunizing peptide for Crkl antisera or phenyl phosphate (20 mmol/L). After denaturing of Crkl immunoprecipitates, Crkl was still immunoprecipitated by Crkl antisera. However, coimmunoprecipitation of STAT5 was not observed. Coincident with STAT5 tyrosine phosphorylation, thrombopoietin induces activation of STAT5 DNA-binding activity as demonstrated by electrophoretic mobility shift assays (EMSA). Using a beta-casein promoter STAT5 binding site as a probe, we have also demonstrated that Crkl antisera supershift the STAT5-DNA complex, suggesting that Crkl is a component of the complex in the nucleus. Furthermore, interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and erythropoietin also induce Crkl-STAT5 complex formation in responding cells in a stimulation-dependent manner. In vitro, glutathione S-transferase (GST)-Crkl bound to STAT5 inducibly through its SH2 domain. These results indicate that thrombopoietin, IL-3, GM-CSF, and erythropoietin commonly induce association of STAT5 and Crkl and that the complex translocates to the nucleus and binds to DNA. Interestingly, such association between STAT5 and Crkl was not observed in cytokine-stimulated murine cells, suggesting an intriguing possibility that components of the human STAT5-DNA complex may be different from those of the murine counterpart.     

Thermodynamic study of phase equilibria in the Pb-Sn-Sb system

A thermodynamic analysis of the phase equilibria in the Pb-Sn-Sb ternary system was conducted. A regular solution approximation based on a two-sublattice model was adopted to describe the Gibbs energy of formation of the individual phases in the binary and ternary systems. In the case of some component binary systems, the effect of pressure also was considered. Experimental data obtained by differential thermal analysis (DTA) and electron probe microanalysis (EPMA) in the present study, along with literature data on phase boundaries and thermochemical properties, form the basis for the evaluated thermodynamic parameters used in the calculation. Calculated and experimental phase boundaries agree fairly well. Present address: Kawasaki Steel Corporation, Chiba 260, Japan.