A thrombolytic decision tree.

We constructed a decision analysis model based on data in the medical literature to estimate the possible outcomes of thrombolytic therapy in patients 50 to 80 years old with possible myocardial infarction. We used the model to test the most likely effects of treatment (determined by averaging the values in reports of large studies) and the worst effects reported so far. The program begins by asking the patient's age, the hours from the onset of pain, and the probability of acute myocardial infarction. It then provides an opportunity to perform sensitivity analyses by changing the values for these variables and for the probability of death in the absence of thrombolytic therapy, as well as for the probability of major stroke and hemorrhage. The counterintuitive findings observed with this program are that the benefits of thrombolytic therapy increase with age and that young patients derive surprisingly little benefit from it.     

Performance evaluation of a multichannel transceiver system forADSL and VHDSL services

The authors study the performance of a multichannel modulation method for asymmetric digital subscriber lines (ADSLs) and very high-speed digital subscriber lines (VHDSLs). In the ADSL case, over all unloaded North American subscriber lines in the test set, a unidirectional 1.536 Mb/s data rate service from the end office to the customer premises is possible on a single twisted pair at an error rate of 10^-7 with at least a 6 dB margin used coded multichannel modulation with sufficient transmit power. In the VHDSL case, data rates in excess of 100 Mb/s can be transmitted reliably, at an error rate of 10^-7, using uncoded multichannel modulation on a single twisted pair over a distance ⩽150 ft with a sufficiently high sampling rate (≈24 MHz) and transmit power. It is shown that a cost-effective multichannel transceiver design suggested for high-speed digital subscriber line (HDSL) service will also work well for ADSL and VHDSL services with only minimal modifications     

Distance determination by the gamma-ray time-of-flight method

The time-of-flight method is studied using coincident annihilation gamma rays with an energy of 511 keV to find the distance from a surface at which they are scattered back for detection. The gamma rays have a good penetration ability, which makes the method suitable for industrial circumstances in which the range is rendered opaque to light by flue gas and aerosols. An accuracy of 1 cm over a distance of 2 m can be obtained by increasing the averaging time by the square of the lengthening factor. The density of the surface can be studied by recording the width of the distribution of the surface measurements. This measurement needs a prolonged averaging time, but the thickness of the slag layer on top of a steel melt can be measured with a maximum error of 1.5 cm at short distances, for example     

An experimental investigation of triboelectrification in cohesive and non-cohesive pharmaceutical powders

A detailed experimental investigation has been undertaken of the triboelectrification process of the pharmaceutical excipient alpha-lactose monohydrate and selected drugs. Particle charge studies involved the design and construction of an apparatus to incorporate pneumatic powder feed, triboelectric charging via a cyclone separator and simultaneous powder charge (Q) and mass (M) measurements using a modified Faraday well. Preliminary studies showed the charging of the selected materials to be unaffected by relative humidity up to 84%, due to the very low hygroscopicity of the powders. Experiments using lactose size fractions with brass, steel and cellulose contact charging surfaces conducted at different feeder gas pressures, gave net electronegative specific charge values (Q/M) for the metal surfaces, and electropositive values for cellulose. Specific charge increased linearly with gas pressure for the metals, and non-linearly for cellulose. Samples of micronised lactose and beclomethasone dipropionate (BDP) showed more tendency than unmicronised samples to adhere to the contact surface which resulted in more complex charging processes. A novel system to analyse the charge and mass data in further detail was developed, giving relative Q/M values at unit time intervals. It is proposed that this will overcome the limitations of reliance on the final net specific charge value. Preliminary results indicated differences in the charging mechanism for lactose in contact with the two metal surfaces.     

Assessment of underground cable ratings based on distributed temperature sensing

Numerous power utilities have installed advanced distributed temperature sensing (DTS) systems to measure the temperature of underground cables. This paper presents a general procedure for real-time assessment of underground cable ratings based on DTS. After the identification and location of hot spots on a cable, the cable installation data, load, and DTS-recorded temperature over a period of time are used to estimate soil thermal parameters and assess cable ratings under normal and overloading conditions. In order to accurately estimate soil thermal parameters, a combined technique of the finite-element method and gradient-based optimization is used. The technique was validated in the laboratory and applied to a rating assessment of a 230-kV/500-MVA cable circuit. The assessed continuous and emergency ratings are helpful in improving the operation of this circuit.     

Allocation of fixed costs in distribution networks with distributed generation

In this paper, we propose a method for the allocation of fixed (capital and nonvariable operation and maintenance) costs at the medium voltage (MV) distribution level. The method is derived from the philosophy behind the widely used MW-mile methodology for transmission networks that bases fixed cost allocations on the "extent of use" that is derived from load flows. We calculate the "extent of use" by multiplying the total consumption or generation at a busbar by the marginal current variations, or power to current distribution factors (PIDFs) that an increment of active and reactive power consumed, or generated in the case of distributed generation, at each busbar, produces in each circuit. These PIDFs are analogous to power transfer distribution factors (PTDFs). Unlike traditional tariff designs that average fixed costs on a per kWh basis across all customers, the proposed method provides more cost-reflective price signals and helps eliminate possible cross-subsidies that deter profitable (in the case of competition) or cost-effective (in the case of a fully regulated industry) deployment of DG by directly accounting for use and location in the allocation of fixed costs. An application of this method for a rural radial distribution network is presented.     

Software architecture-centric methods and agile development

The agile software development paradigm and plan-driven approaches each have their strengths and shortcomings. The former emphasizes rapid, flexible development, while the latter emphasizes project and process infrastructure. Many practitioners, particularly of agile methods, tend-to view software architecture in light of the plan-driven side of the spectrum. They think that architecture-centric methods are too much work, equating them with high-ceremony processes emphasizing document production. But many elements make up a successful development approach, including process, product, technology, people, and tools. Software architecture is part of product quality and isn't tied to a particular process, technology, culture, or tool. This article explores the relationship and synergies between architecture-centric design and analysis methods and the extreme programming framework. We chose to focus on XP because it's one of the most mature and best-known agile practices.     

Dissipative processes during cyclic hardening of spheroidal graphite cast iron

The hardening of spheroidal graphite cast irons alloyed by vanadium via chemical dispersion has been studied. Strain hardening is experimentally found to effectively occur in a cast iron with a relatively low vanadium content (0.5 wt %). Dissipative processes in cast irons with dispersed vanadium carbide inclusions are analyzed. An increase in the degree of dispersion of vanadium carbide inclusions is shown to favor more complete dissipation of the supplied energy into heat and decreases the level of damage in the material.