Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders

As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing the well-being and quality of life of sufferers and their families. In recent decades, due to reduced work-related levels of physical activity, and key research insights, prescribing adequate exercise has become an innovative strategy to prevent or delay the onset of these pathologies and has been demonstrated to have therapeutic benefits when used as a sole or combination treatment. Recent evidence suggests that the beneficial effects of exercise on the brain are related to several underlying mechanisms related to muscle–brain, liver–brain and gut–brain crosstalk. Therefore, this review aims to summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and to highlight the established and potential underlying mechanisms involved in exercise–brain communication and their benefits for physiology and brain function.     

A new input indicator for the assessment of science &; technology research?

Traditional input indicators of research performance, such as research funding, number of active scientists, and international collaborations, have been widely used to assess countries’ publication output. However, while publication in today’s English-only research world requires sound research in readable English, English proficiency may be a problem for the productivity of non-native English-speaking (NNES) countries. Data provided by the Brazilian National Research Council (CNPq) containing the academic profile of 51,223 Brazilian researchers show a correlation between English proficiency and publication output. According to our results, traditional input indicators may fall short of providing an accurate representation of the research performance of NNES developing countries.     

Changes in blood lead of a recreational shooter

We have measured the concentration and isotopic composition of lead in blood over a 15-month period for a subject who undertook recreational shooting in outdoor and indoor firing ranges on an irregular basis. We have also measured the isotopic composition in cast lead, Cu-jacketed and Teflon-coated bullets, propellant and primer from which he assembled the cartridges. Blood lead concentration increased from 3.2 to 6.7 microg/dl with use of dominantly cast lead bullets in the outdoor range. In two intervals when no firing was undertaken for 3-4 months, the blood lead concentrations either decreased towards a baseline value in the case where only Cu-jacketed bullets were fired or remained elevated when dominantly cast lead bullets were fired. The propellants contained <2 ppm Pb and contribute negligibly to blood lead. The isotopic composition of the primer used for all bullets was consistent with a source from the US. The bullets were of different materials and made in Australia and the US, with lead from sources of different geological age and hence different isotopic signatures. Variations in blood lead concentration and isotopic composition appear most strongly influenced by the bullets. Although more expensive, the use of Cu-jacketed bullets, non-lead primers and well-ventilated indoor firing ranges would lessen the health impacts of recreational shooting.     

SPIFI: a direct-detection imaging spectrometer for submillimeter wavelengths

The South Pole Imaging Fabry-Perot Interferometer (SPIFI) is the first instrument of its kind-a direct-detection imaging spectrometer for astronomy in the submillimeter band. SPIFI's focal plane is a square array of 25 silicon bolometers cooled to 60 mK; the spectrometer consists of two cryogenic scanning Fabry-Perot interferometers in series with a 60-mK bandpass filter. The instrument operates in the short submillimeter windows (350 and 450 microm) available from the ground, with spectral resolving power selectable between 500 and 10,000. At present, SPIFI's sensitivity is within a factor of 1.5-3 of the photon background limit, comparable with the best heterodyne spectrometers. The instrument's large bandwidth and mapping capability provide substantial advantages for specific astrophysical projects, including deep extragalactic observations. We present the motivation for and design of SPIFI and its operational characteristics on the telescope.     

Retrieval of the ultraviolet aerosol optical depth during a spring campaign in the Bavarian Alps

A measurement campaign was organized in March 1999 in the Bavarian Alps as part of the European project, Characteristics of the UV Radiation Field in the Alps (CUVRA), to analyze the effect of altitude, aerosols, and snow cover on ground-level UV spectral irradiance. We present the results of simultaneous measurements of aerosol optical depth (AOD) made at various sites on two cloudless days in March 1999. The two days exhibited different aerosol conditions. Results derived from spectral measurements of UV irradiance are compared with data from filter radiometer measurements made at discrete wavelengths extending from the UV to the near IR. The different methods generated values for the AOD that were in good agreement. This result confirms that one can use either method to retrieve the AOD with an uncertainty of approximately 0.03-0.05. On 18 March, high turbidity was observed at low altitude (400-nm AOD approximately 0.5 at 700 m above sea level), and the AOD decreased regularly with altitude; on 24 March, the turbidity was much less (0.11 at 700 m above sea level). On both days very low AODs (0.05-0.09) were measured at 3000 m above sea level. The spectral dependence of the AOD is often parameterized by the angstrom relationship; the alpha parameter is generally difficult or impossible to retrieve from spectral measurements because of the relatively narrow wavelength range (320-400 nm), and only one of the spectro-radiometers used during the campaign permits this retrieval. In most cases, during this field campaign, alpha was found by filter sunphotometers to be 1.1-1.5.     

Estimation and vicarious validation of urban vegetation abundance by spectral mixture analysis

Both moderate and high spatial resolution imagery can be used to quantify abundance and distribution of urban vegetation for urban landscape management and to provide inputs to physical process models. Estimation of vegetation fraction from Landsat ETM+ and Quickbird allows for operational monitoring and reconnaissance at moderate resolution with calibration and vicarious validation at higher resolution. Establishing a linear correspondence between ETM-derived vegetation fraction and Quickbird-derived vegetation fraction facilitates the validation task by extending the spatial scale from 30 × 30 m to a more manageable 2.8 × 2.8 m. A comparative analysis indicates that urban reflectance can be accurately represented with a three component linear mixture model for both Landsat ETM+ and Quickbird imagery in the New York metro area. The strong linearity of the Substrate Vegetation Dark surface (SVD) mixture model provides consistent estimates of illuminated vegetation fraction that can be used to constrain physical process models that require biophysical inputs related to vegetation abundance. When Quickbird-derived 2.8 m estimates of vegetation fraction are integrated to 30 m scales and coregistered to Landsat-derived 30 m estimates, median estimates agree with the integrated fractions to within 5% for fractions > 0.2. The resulting Quickbird-ETM+ scatter distribution cannot be explained with estimate error alone but is consistent with a 3% to 6% estimation error combined with a 17 m subpixel registration ambiguity. The 3D endmember fraction space obtained from ETM+ imagery forms a ternary distribution of reflectance properties corresponding to distinct biophysical surface types. The SVD model is a reflectance analog to Ridd's V–I–S land cover model but acknowledges the fact that permeable and impermeable surfaces cannot generally be distinguished on the basis of broadband reflectance alone. We therefore propose that vegetation fraction be used as a proxy for permeable surface distribution to avoid the common erroneous assumption that all nonvegetated surfaces along the gray axis are completely impermeable. Comparison of mean vegetation fractions to street tree counts in New York City shows a consistent relationship between minimum fraction and tree count. However, moderate and high resolution areal estimates of vegetation fraction provide complementary information because they image all illuminated vegetation, including that not counted by the in situ street tree inventory.     

Effects of the purpose of rating on accuracy in observing teacher behavior and evaluating teaching performance.

Previous research has suggested that ratings used to make administrative decisions are lenient when compared with ratings obtained for research purposes only. The present study examined the effects of the purpose of rating on multivariate measures of accuracy in observing teacher behavior as well as measures of accuracy in evaluating teaching performance. 45 undergraduates viewed and evaluated videotaped lectures under conditions in which they were informed that their ratings would be used for research only or for making important decisions about those being rated. The purpose of rating did not affect measures of accuracy in rating the frequency with which a number of critical behaviors occurred on each tape. The purpose of rating also did not affect multivariate measures of performance rating accuracy. Purpose did, however, affect the relationship between accuracy in observing teacher behavior and accuracy in evaluating teaching performance. It is suggested that purpose affects the way in which raters process behavioral information without necessarily affecting the general level of rating. (40 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Are results of randomized controlled trials useful to psychotherapists?

Two clinicians provided opposite answers to the title question: Persons argued that information from randomized controlled trials (RCTs) is vital to clinicians, and Silberschatz argued that information from RCTs is irrelevant to clinicians. Persons argued that clinicians cannot provide top quality care to their patients without attending to findings of RCTs and that clinicians have an ethical responsibility to inform patients about, recommend, and provide treatments supported by RCTs before informing patients about, recommending, and providing treatments shown to be inferior in RCTs or not evaluated in RCTs. Silberschatz argued that RCTs do not and cannot answer questions that concern practicing clinicians. He advocates alternative research approaches (effectiveness studies, quasi-experimental methods, case-specific research) for studying psychotherapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Avoiding Change Orders in Public School Construction

Increased student enrollment and the current poor state of the educational infrastructure require the construction of more school buildings and the renovation of many of the existing ones. The large number and magnitude of change orders in these projects constitute an impediment to the rapid and economic delivery of these projects. A total of 6,585 change orders filed in a school district’s projects in the 5 1/2 year period from 1999 to 2004 were analyzed in five categories including owner-directed changes, code compliance issues, errors/omissions in contract documents, discovered or changed conditions, and others. The results of the study indicate that the dollar value of change orders relative to the original contract can be reduced if preventive measures are taken. These measures include choosing the right construction management firm, emphasizing the definition of project scope early in the project, and effectively managing the precontract activities by conducting value engineering and constructability reviews. The results indicate that school projects can be completed with change orders not exceeding 5% of the contract value if these measures are taken. This study is of relevance to practitioners involved in school design and construction projects.