Using non-invasive magnetic resonance (MR) techniques and a histological approach, we assessed the outcomes of perinatal exposure at a low dose of 3,3′-DCBPA (2-chloro-4-[1-(3-chloro-4-hydroxyphenyl)-1-methylethyl]phenol) and/or 3,5-DCBPA (2,6-dichloro-4-[1-(4-hydroxyphenyl)-1-methylethyl]phenol) on mice livers.
Materials and methods
Fertilized female Swiss mice were injected intraperitoneally during gestation and lactation with either vehicle control, 20 μg/kg/day of BPA, 3,5-DCBPA, 3,3′-DCBPA or a mixture (mix-DCBPA). Complementary methods were used to evaluate, in male and female pups, (1) liver structure by texture analysis of images obtained through MR imaging (MRI) and histology, (2) hepatic lipid composition through in vivo 1H MR spectroscopy (1H MRS).
Results
Principal component analysis of texture parameters showed no structural modification of the liver with BPA and DCBPA treatments. Accordingly, no hepatic microvesicular steatosis was observed through hematoxylin–eosin staining. Compared to control, MRS revealed no difference in lipid composition for BPA, 3,5-DCBPA or 3,3′-DCBPA groups. However, MRS detected a significant increase in the mix-DCBPA groups for the saturated component of fatty acids (FA), total unsaturated FA bond index and polyunsaturated FA bond index.
Conclusion
Prior to any structural changes, polyunsaturated fatty acids significantly increased in young male and female mice exposed perinatally at a low dose to a mixture of dichlorinated BPA.
This paper presents a novel design approach for the finite frequency (FF) H∞ filtering problem for discrete‐time state‐delayed systems with quantized measurements. The system state and output are assumed affected by FF external noises. Attention is focused on the design of a stable filter that guarantees the stability and a prescribed ?2 gain performance level for the filtering error system in the FF domain of input noises. Sufficient conditions for the solvability of this problem are developed by choosing an appropriate Lyapunov‐Krasovskii functional based on the delay partitioning technique and using the FF ?2 gain definition combined with the generalized S‐procedure. Then, by means of Finsler's lemma, the derived conditions are linearized and additional slack variables are further introduced to more flexible result. Final filter design conditions are consequently established in terms of linear matrix inequalities in three different frequency ranges, ie, low‐, middle‐ and high‐frequency range. Finally, a simulation example is presented to illustrate the effectiveness and the merits of the proposed approach. 相似文献
In recent years, trimeric surfactants have created excitement in the surfactant field because of their properties, which have been found to be better than monomeric or dimeric homologues. Only a limited number of trimeric surfactants have been synthesized and studied so far, probably owing to the difficulty in synthesis. In this article, we synthesized some novel star‐shaped trimeric cationic surfactants based on the alkylation of the 3 hydroxyl groups of the phloroglucinol nuclei as a core (i.e., spacer) with 3 dodecyl or 3 octyl groups (as tails) for the surfactant. The chemical structures were confirmed by nuclear magnetic resonance, Fourier transform infrared, mass spectrometry, and elemental analysis; also the critical micelle concentration was determined by electrical conductivity measurements. These surfactants were used in the synthesis of mesoporous silica nanoparticles by the sol–gel method. The silica particles shape and size were determined using field emission scanning electron microscopy and high‐resolution transmission electron microscopy images. Furthermore, the corrosion inhibitor capability of these surfactants was investigated by monitoring the corrosion rate of iron sheets in 0.5 M hydrochloric acid in the presence and in the absence of different surfactants at 45°C based on the weight loss method. We have used cetyltrimethylammonium bromide (CTAB) as a positive control, the obtained results showed a high inhibition efficiency at very low concentrations, and the prepared trimeric surfactants exhibited a higher anticorrosion efficiency than the CTAB surfactants. 相似文献
A library of short di‐, tri‐, and tetra‐peptides with an s‐triazine moiety at the N terminus and either an amide or ethyl ester C terminus was prepared in solution and on the solid phase. The two remaining positions of the s‐triazine moiety were substituted with methoxy, morpholino, or piperidino groups. All the synthesized peptide derivatives were analyzed by HPLC and fully characterized by IR spectroscopy, 1H and 13C NMR spectroscopy, elemental analysis, and mass spectrometry (MALDI TOF/TOF). A preliminary study of the antileishmanial activity of the 1,3,5‐triazinyl peptide derivatives revealed that four dipeptide amide derivatives showed higher antipromastigote or antiamastigote activity than the reference standard drug miltefosine with no significance acute toxicity. 相似文献
In cooperative communications, the problem of error propagation has a detrimental effect on the diversity order of the wireless system. To mitigate such an effect, we present a relaying scheme that is based on the absolute value of the log-likelihood ratio (LLR) of the received message signals at both the relay node and the destination node. The calculated LLR values are then compared to each other and based on the result of the comparison, a decision is made on whether or not to activate the relay node. The proposed scheme does not rely on any threshold, and is thus simple in nature. A closed-form expression is derived for the bit-error-rate (BER) of the proposed scheme. The theoretical developments are validated by simulations. As a means for performance measurement, the proposed scheme is compared to its counterparts and is shown to provide a better BER performance at a much lower complexity. Furthermore, a closed-form expression of the outage probability is also derived. 相似文献
Glaucoma is a disease characterized by damaging the optic nerve head, this can result in severe vision loss. An early detection and a good treatment provided by the ophthalmologist are the keys to preventing optic nerve damage and vision loss from glaucoma. Its screening is based on the manual optic cup and disc segmentation to measure the vertical cup to disc ratio (CDR). However, obtaining the regions of interest by the expert ophthalmologist can be difficult and is often a tedious task. In most cases, the unlabeled images are more numerous than the labeled ones.We propose an automatic glaucoma screening approach named Super Pixels for Semi-Supervised Segmentation “SP3S”, which is a semi-supervised superpixel-by-superpixel classification method, consisting of three main steps. The first step has to prepare the labeled and unlabeled data, applying the superpixel method and bringing in an expert for the labeling of superpixels. In the second step, We incorporate prior knowledge of the optic cup and disc by including color and spatial information. In the final step, semi-supervised learning by the Co-forest classifier is trained only with a few number of labeled superpixels and a large number of unlabeled superpixels to generate a robust classifier. For the estimation of the optic cup and disc regions, the active geometric shape model is used to smooth the disc and cup boundary for the calculation of the CDR. The obtained results for glaucoma detection, via an automatic cup and disc segmentation, established a potential solution for glaucoma screening. The SP3S performance shows quantitatively and qualitatively similar correspondence with the expert segmentation, providing an interesting tool for semi-automatic recognition of the optic cup and disc in order to achieve a medical progress of glaucoma disease. 相似文献
Microbial fuel cells (MFCs) are bio-electrochemical systems that can directly convert the chemical energy contained in an effluent into bioelectricity by the action of microorganisms. The performance of these devices is heavily impacted by the choice of the material that forms the cathode. This work focuses on the assessment of ferroelectric and photocatalytic materials as a new class of non-precious catalysts for MFC cathode construction. A series of cathodes based on mixed oxide solid solution of LiTaO3 with WO3 formulated as Li1-xTa1-xWxO3 (x=0, 0.10, 0.20 and 0.25), were prepared and investigated in MFCs. The catalyst phases were synthesized, identified and characterized by DRX, PSD, MET and UV-Vis absorption spectroscopy. The cathodes were tested as photoelectrocatalysts in the presence and in the absence of visible light in devices fed with industrial wastewater. The results revealed that the catalytic activity of the cathodes strongly depends on the ratio of substitution of W6+ in the LiTaO3 matrix. The maximum power densities generated by the MFC working with this series of cathodes increased from 60.45 mW·m-3 for x=0.00 (LiTaO3) to 107.2 mW·m-3 for x=0.10, showing that insertion of W6+ in the tantalate matrix can improve the photocatalytic activity of this material. Moreover, MFCs operating under optimal conditions were capable of reducing the load of chemical oxygen demand by 79% (CODinitial=1030 mg·L-1). 相似文献
As a high potential renewable power source, solar energy is becoming one of the most important energies of the future. Recently, there has been an enormous increase in the understanding of the operational principle of photovoltaic devices, which has led to a rapid increase in the power conversion efficiencies of such devices. Solar cells vary under temperature changes; the change in temperature will affect the power output from the cells. This paper discusses the effect of light intensity and temperature on the performance parameters of monocrystalline and polycrystalline silicon solar devices. In this paper, the performance and overview use of solar cells is expressed. The role of temperature on the electric parameters of solar cells has been studied. The experimental results show that all electrical parameters of the solar cells, such as maximum output power, open circuit voltage, short circuit current, and fill factor, have changed with temperature variation. Solar cell performance decreases with increasing temperature, fundamentally owing to increased internal carrier recombination rates caused by increased carrier concentrations. The operating temperature plays a key role in the photovoltaic conversion process. Both the electrical efficiency and the power output of a photovoltaic (PV) module depend linearly upon the operating temperature. Solar cells vary under temperature changes; the change in temperature will affect the power output from the cells.
Lead borosilicate glasses, of chemical composition 20SiO2-xPbO-(15 + x)B2O3-5WO2-10ZnO-(50-2x) Na2O (where x = 5, 10, 15, 20, 25) were prepared using the normal melt-quenching technique. The samples were examined using a Philips Analytical X-ray diffraction system in order to check their amorphous nature. The effect of increasing B2O3 and PbO content on glass transition temperature was examined using Differential Thermal Analysis measurements (DTA). The results of DTA showed that both melting and glass transition temperatures decrease with increase of lead and boron oxides. Density and its related parameters have been determined to study the effect of lead-boron content on the structural properties of the prepared samples. Based on the density and DTA results, the network forming role of Pb and B ions was proved. The optical properties of the glass samples have been obtained using UV-VIS measurements. The optical parameters, such as optical band gap, Urbach energy, refractive index, and electronic polarizability were deduced based on the optical data. The observed increase in optical band gap and decrease in Urbach energy as well as the red shift in the absorption spectra arise due to the formation of non-bridging oxygen. 相似文献