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61.
Mary Jasmin Ang Sueun Lee Mai Wada Poornima D. E. Weerasinghe-Mudiyanselage Sung-Ho Kim Taekyun Shin Tae-Il Jeon Seung-Soon Im Changjong Moon 《International journal of molecular sciences》2021,22(11)
Changes in structural and functional neuroplasticity have been implicated in various neurological disorders. Sterol regulatory element-binding protein (SREBP)-1c is a critical regulatory molecule of lipid homeostasis in the brain. Recently, our findings have shown the potential involvement of SREBP-1c deficiency in the alteration of novel modulatory molecules in the hippocampus and occurrence of schizophrenia-like behaviors in mice. However, the possible underlying mechanisms, related to neuronal plasticity in the hippocampus, are yet to be elucidated. In this study, we investigated the hippocampus-dependent memory function and neuronal architecture of hippocampal neurons in SREBP-1c knockout (KO) mice. During the passive avoidance test, SREBP-1c KO mice showed memory impairment. Based on Golgi staining, the dendritic complexity, length, and branch points were significantly decreased in the apical cornu ammonis (CA) 1, CA3, and dentate gyrus (DG) subregions of the hippocampi of SREBP-1c KO mice, compared with those of wild-type (WT) mice. Additionally, significant decreases in the dendritic diameters were detected in the CA3 and DG subregions, and spine density was also significantly decreased in the apical CA3 subregion of the hippocampi of KO mice, compared with that of WT mice. Alterations in the proportions of stubby and thin-shaped dendritic spines were observed in the apical subcompartments of CA1 and CA3 in the hippocampi of KO mice. Furthermore, the corresponding differential decreases in the levels of SREBP-1 expression in the hippocampal subregions (particularly, a significant decrease in the level in the CA3) were detected by immunofluorescence. This study suggests that the contributions of SREBP-1c to the structural plasticity of the mouse hippocampus may have underlain the behavioral alterations. These findings offer insights into the critical role of SREBP-1c in hippocampal functioning in mice. 相似文献
62.
Reactive absorption using aqueous amine solutions is the technically most feasible retrofit option for the separation of CO2 from flue gases. Frequently discussed issues are the realization of a cost‐effective increase in efficiency in the sophisticated overall absorption process and the minimization of the energy demand for solvent regeneration under operating conditions. However, the influence of degradation phenomena on capacity and energy efficiency during the absorption‐regeneration cycles using blended monoethanolamine solutions has been less considered so far. The decrease in capacity depends in particular on time, temperature, O2‐ and SO2 concentration in the flue gas and has to be considered in plant design. Addition of degradation inhibitors decreases the energy requirements. 相似文献
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The low-temperature geothermal potential of the flooded Gaspé Mines, near Murdochville, Québec, Canada, has been estimated from a long-term pumping test and numerical groundwater flow modelling. A former mining shaft was used to pump water for 3 weeks at a rate averaging 0.062 m3/s (3720 L/min). A mean recovery temperature equal to 6.7 °C and a maximum drawdown of 3.63 m were observed during this test. The observed drawdown was reproduced with a three-dimensional finite element model that simulates groundwater flow through the mine workings and surrounding rock mass. The model was then used to simulate longer-term pumping performed for heat recovery. Modelling results combined with a simplified energy balance calculation suggest that a sustainable energy extraction rate is attained at a pumping rate of 0.049 m3/s (2940 L/min), with a corresponding geothermal energy production potential of 765 kW, assuming a return water temperature of 3 °C. This energy could be extracted with heat pumps and used for space heating at the town's industrial park. 相似文献
65.
Krucker M Lienau A Putzbach K Grynbaum MD Schuler P Albert K 《Analytical chemistry》2004,76(9):2623-2628
Highly selective reversed phases (C(30) phases) are self-packed in 250 microm inner diameter fused-silica capillaries and employed for capillary HPLC separation of shape-constrained natural compounds (tocopherol homologues, vitamin E). Miniaturized hyphenated systems such as capillary HPLC-ESI-MS (positive ionization mode) and, with special emphasis, continuous-flow capillary HPLC- NMR are used for structural determination of the separated compounds. Despite the small amount of sample available (1.33 microg of each tocopherol), the authors have been able to monitor the capillary HPLC separation under continuous-flow (1)H NMR conditions, thus allowing an immediate peak identification. Further structural assignment was carried out in the stopped-flow NMR mode as shown, for example, by a 2D (1)H,(1)H COSY NMR spectrum of alpha-tocopherol. We demonstrate in this paper the considerable potential of hyphenated capillary separations coupled to MS and NMR for the investigation of restricted amounts of sample. 相似文献
66.
F. Intonti V. Emiliani C. Lienau T. Elsaesser R. Nötzel† K. H. Ploog† 《Journal of microscopy》2001,202(1):193-201
Excitons in a GaAs quantum wire were studied in high-resolution photoluminescence experiments performed at a temperature of about 10 K with a spatial resolution of 160 nm and a spectral resolution of 100 µeV. We report the observation of quasi-one-dimensional excitons which are delocalized over a length of up to several micrometres along the quantum wire. Such excitons give rise to a 10 meV broad luminescence band, representing a superposition of transitions between different delocalized states. In addition, we find a set of sharp luminescence peaks from excitons localized on a sub150 nm length scale. Theoretical calculations of exciton states in a disordered quasi-one-dimensional potential reproduce the experimental results. 相似文献
67.
Jasmin Waser-Althaus Achim Salamon Marcus Waser Celestino Padeste Michael Kreutzer Uwe Pieles Bert Müller Kirsten Peters 《Journal of materials science. Materials in medicine》2014,25(2):515-525
Polyetheretherketone (PEEK) generally exhibits physical and chemical characteristics that prevent osseointegration. To activate the PEEK surface, we applied oxygen and ammonia plasma treatments. These treatments resulted in surface modifications, leading to changes in nanostructure, contact angle, electrochemical properties and protein adhesion in a plasma power and process gas dependent way. To evaluate the effect of the plasma-induced PEEK modifications on stem cell adhesion and differentiation, adipose tissue-derived mesenchymal stem cells (adMSC) were seeded on PEEK specimens. We demonstrated an increased adhesion, proliferation, and osteogenic differentiation of adMSC in contact to plasma-treated PEEK. In dependency on the process gas (oxygen or ammonia) and plasma power (between 10 and 200 W for 5 min), varying degrees of osteogenic differentiation were induced. When adMSC were grown on 10 and 50 W oxygen and ammonia plasma-treated PEEK substrates they exhibited a doubled mineralization degree relative to the original PEEK. Thus plasma treatment of PEEK specimens induced changes in surface chemistry and topography and supported osteogenic differentiation of adMSC in vitro. Therefore plasma treated PEEK holds perspective for contributing to osseointegration of dental and orthopedic load-bearing PEEK implants in vivo. 相似文献
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