Electrodynamic headphones and woofers for application in magnetic resonance imaging scanners

Electrodynamic speakers compatible with (functional) magnetic resonance imaging (MRI) are described. The speakers magnets are removed, their function is replaced by the scanner's magnetic field, resulting in an uncommon but efficient operation. The method can be used with headphones as well as woofers. Functional MRI is not associated with any known biological risks, but as a method for visualization of task-specific activation of brain regions it is undesirably noisy. Thus, it requires both noise protection and efficient sound transmission systems for delivering acoustic stimuli to subjects. Woofers could possibly be used in active noise-control systems. The speakers described in this paper can be used for either task.     

Granulocyte colony-stimulating factor worsens the outcome of experimental Klebsiella pneumoniae pneumonia through direct interaction with the bacteria

Besides its well-established effects on granulocytopoiesis, granulocyte colony-stimulating factor (G-CSF) has been shown to have direct effects on the recruitment and bactericidal ability of neutrophils, resulting in improved survival of experimentally infected animals. We studied the effect of G-CSF on the course of experimental pneumonia induced by Klebsiella pneumoniae, an important gram-negative bacillary pulmonary pathogen. Using a highly reproducible murine model, we here show the paradoxical finding that mortality from infection was significantly increased when animals received G-CSF before induction of pneumonia. Administration of G-CSF promoted replication of bacteria in the liver and spleen, thus indicating an impairment rather than an enhancement of antibacterial mechanisms. By contrast, a monoclonal antibody against Klebsiella K2 capsule significantly reduced bacterial multiplication in the lung, liver, and spleen, and abrogated the increased mortality caused by G-CSF. In vitro studies showed a direct effect of G-CSF on K pneumoniae resulting in increased capsular polysaccharide (CPS) production. When bacteria were coincubated with therapeutically achievable concentrations of G-CSF, phagocytic uptake and killing by neutrophils was impaired. Western blot analysis showed three binding sites of G-CSF to K pneumoniae. Binding of 125I-G-CSF to K pneumoniae was displaced by an excess of unlabeled G-CSF, whereas an unrelated cytokine, interleukin-1alpha, did not compete with G-CSF binding to the bacteria. Thus, in this model, the direct effect of G-CSF on a bacterial virulence factor, CPS production, outweighed any beneficial effect of G-CSF on recruitment and stimulation of leukocytes.     

A 32-channel charge readout IC for programmable, nonlinearquantization of multichannel detector data

A Charge Readout Integrated Circuit (CRIC) which converts detector charges to digital codes is described. The CRIC provides 32 channels of circuitry needed to form charge-to-digital converters having a total dynamic range of 17 b comprised of 4 b of pre-amp gain control and a conversion range of 13 b. Each channel includes a switched-capacitor integrator, a double-sampling amplifier, a sampling comparator, and a 12-b digital latch, forming a pipeline from which a new conversion result is readout every 50 μs. The data conversion scheme implements a programmable compression curve, which is stored as a lookup table in an off-chip, digital memory. In addition to the lookup table, data conversion requires an off-chip digital-to-analog converter, both of which may be shared by any number of CRIC's. The CRIC was fabricated using a 3-μm, n-well BiCMOS process, and occupies a die area of 5.1 mm×7.5 mm. It operates at 10 MHz, consumes 440 mW from ±5-V supplies, and has a demonstrated input-referred noise performance of 2.2 μV r.m.s., i.e., 1400 e^- on 100 pF of shunt capacitance     

High dynamic range temperature point sensor using greenfluorescence intensity ratio in erbium-doped silica fiber

We propose a sensor based on the temperature dependant behavior of the two lines of green emission of the erbium ion. The ratio of the intensities of these two lines presents a very low dependance on pump wavelength and pump power fluctuations. The sensitivity of the ratio is 0.013/°C between room temperature and 600°C. In addition, the measurement is self-calibrated     

Optical fiber-polymer guide coupling by a tapered graded indexglass guide

A new four layer tapered coupler (FLTC) has been studied and tested, able to transfer light efficiently from a monomode fiber to a polymer film guide by means of an auxiliary graded index glass waveguide. A simple theory has been developed to calculate the maximum efficiency of these structures. Experiments have been performed, at λ=1.321 μm, on several FLTC samples, containing K⁺-Na⁺ ion-exchanged glass waveguides and spin coated poly-3BCMU films. Insertion losses in the range 3-6.5 dB have been measured, depending on the taper configuration. The agreement between theoretical and experimental data is good, provided that a suitable ripple of the taper profile is assumed. The application of the new coupler to future integrated waveguide systems, including passive glass components and polymer based all optical devices, is assessed     

Relations between cardiac and vascular structure in patients with primary and secondary hypertension

BACKGROUND: Data on cardiac and vascular structure in secondary hypertension are generally scarce, and no data on the interrelations between cardiac mass and structural characteristics of the vessel wall, both in large and in small resistance arteries, are presently available. OBJECTIVES: The aim of this study was to investigate the relation between structural changes in subcutaneous small arteries, left ventricular mass and wall thickness of the common carotid artery in patients with primary and secondary hypertension. METHODS: Seventy-four subjects were included in the study: 11 patients with pheochromocytoma, 14 with primary aldosteronism (PA), 19 with renovascular hypertension (RVH), 18 with essential hypertension (EH) and 12 normotensive (NT) control subjects. All subjects were submitted to a biopsy of subcutaneous fat. Morphologic characteristics of subcutaneous small resistance arteries (relaxed diameter <300 microm) were directly evaluated using a micromyographic technique. All subjects were submitted to calculation of left ventricular mass index (LVMI) and common carotid artery intima-media thickness (CCIMT), using ultrasound technique. RESULTS: The correlation coefficients between the media to lumen ratio in subcutaneous small arteries (M/L) and LVMI or between M/L and CCIMT were closer in RVH than in pheochromocytoma, EH or NT; in PA the correlation coefficients were slightly less close than those in RVH. An excess prevalence of carotid plaques in RVH was observed. CONCLUSIONS: A close relation between small resistance artery morphology and cardiac or carotid artery structure may be observed in those hypertensive patients in whom the renin-angiotensin-aldosterone system is activated. In constrast, in NT, EH and pheochromocytoma no significant correlation between M/L and LVMI or CCIMT was observed.