Absorption and scattering properties of dense ensembles of nonspherical particles

The purpose of this work is to show that an appropriate multiple T-matrix formalism can be useful in performing qualitative studies of the optical properties of colloidal systems composed of nonspherical objects (despite limitations concerning nonspherical particle packing densities). In this work we have calculated the configuration averages of scattering and absorption cross sections of different clusters of dielectric particles. These clusters are characterized by their refraction index, particle shape, and filling fraction. Computations were performed with the recursive centered T-matrix algorithm (RCTMA), a previously established method for solving the multiple scattering equation of light from finite clusters of isotropic dielectric objects. Comparison of the average optical cross sections between the different systems highlights variations in the scattering and absorption properties due to the electromagnetic interactions, and we demonstrate that the magnitudes of these quantities are clearly modulated by the shape of the primary particles.     

Advantages of molecularly imprinted polymers LC-ESI-MS/MS for the selective extraction and quantification of chloramphenicol in milk-based matrixes. comparison with a classical sample preparation

A simple and fast selective extraction of the antibiotic chloramphenicol (CAP) from milk (raw milk, skimmed milk, and milk powder) using a molecularly imprinted polymer (MIP) sorbent is described. The method entails a single centrifugation step prior to loading the supernatant onto the MIP cartridge and subsequent elution with a mixture of solvents. CAP was further analyzed by isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) operating in negative ionization acquisition mode. The advantages of the MIP approach were assessed by comparing the data generated from a classical solid-phase and liquid-liquid extractions procedure, previously developed in our laboratory. A better recovery of CAP due to an enhanced selectivity and a faster turnaround time (18 samples processed within 3 h compared to 8 h with the classical approach) were evidenced when using the MIP cleanup. The analysis of CAP in raw milk was further validated according to the 2002/657/EC European Union criteria for the analysis of veterinary drug residues at the minimum required performance limit (MRPL) of 0.3 microg/kg, using CAP-d(5) as internal standard. Non-internal-standard corrected recovery values ranged between 50% and 87% over the range of concentrations considered. The decision limit (CCalpha) and detection capability (CCbeta) were calculated to be 0.06 and 0.10 microg/kg, respectively.     

Highly potent fluorescence-tagged nonimidazole histamine H3 receptor ligands

Different (3-phenoxypropyl)piperidine derivatives have been coupled to fluorescent moieties (5-dimethylaminonaphthalene-1-sulfonyl, carbazol-9-ylcarbonyl, 2-cyanoisoindol-1-yl, 2-cyanobenzo[f]isoindol-1-yl, 2,4-dinitrobenzen-1-yl, 2,4-diaminophenyl, 7-nitrobenzofurazan-4-yl, 7-aminosulfonylbenzofurazan-4-yl, 4-methylcoumarin-6-yl) as novel histamine H(3) receptor ligands. They have been synthesised starting from piperidine in a few steps. The compounds display good to excellent histamine hH(3) receptor affinities with K(i) values ranging from 13.4 to 0.048 nM. Some of the new compounds belong to the most potent ligands known so far and may act as tools for identification and understanding of the binding site on the histamine H(3) receptor. In vivo screening on selected derivatives of Sanger's reagent showed antagonist potencies with ED(50) values from 7.9 to 0.39 mg kg(-1), p.o.     

Spatial interaction modelling

Abstract. Spatial interaction (SI) is the process whereby entities at different points in physical space make contacts, demand/supply decisions or locational choices. The entities can be individuals or firms and the choices can include housing, jobs, production quantities, exports, imports, face-to-face contacts, schools, retail centres and activity centres. The first SI models can be grouped under the generic heading gravity models. Their main characteristic is that they model the behaviour of demand or supply segments, rather than that of individuals and firms. This article traces the development of these models from their inception in the early part of the twentieth century to the present. The key advances include the replacement of the gravity analogy by the more general concepts of entropy or information theory, a statistical framework commonly used in physics. With the arrival of the regional science paradigm over 50 years ago, a key challenge has been to broaden these models compared to those arising in spatial economics, thus arriving at a more inclusive probabilistic framework. These efforts are discussed here, as well as inclusion of geographical advances, embracing activities as generators of travel, time-geography, recognition of spatial interdependencies, and use of neuro-computing principles.     

French validation of a new version of the Driver Behavior Questionnaire (DBQ) for drivers of all ages and level of experiences

The purpose of this study was to validate a new version of the Driver Behavior Questionnaire (DBQ) on a sample of French drivers in order to gain a better understanding of different driver behaviors, by differentiating two types of violations (aggressive and ordinary), three types of errors (dangerous, inattention and inexperience) and by taking positive behaviors into account. 525 drivers (205 men and 320 women), between 18 and 79 years of age, filled in a questionnaire on line including the 41 items in the new version of the DBQ and information relative to their mobility and their accident history. Exploratory factor analysis confirmed a six-factor structure: “dangerous errors”, “inattention errors”, “inexperience errors”, “ordinary violations”, “aggressive violations” and “positive behaviors”. A revised version with 23 items of the new version of the DBQ was produced by selecting the items that loaded most strongly on the six factors. The results also showed the link between demographic variables (age and gender), mobility (kilometers driven weekly), the DBQ scores and the involvement in an accident in the previous five years. This study permitted to validate a more detailed version of the “Driving Behavior Questionnaire” among French drivers of all age and all level of experience.     

Effect of fabric method on instability behavior of granular material

It is well known that the specimen preparation method and the resulting sand fabric significantly affect sand behavior and sand liquefaction resistance. In many cases, the fabric and behavior of reconstituted sand samples do not represent those of in-situ deposits. Therefore, understanding the influence of specimen preparation and sand fabric on its behavior, particularly at the critical state, is important for relating the behavior of laboratory reconstituted specimens to in-situ soil response. In this study, the effect of sand fabric and specimen preparation method on the shearing behavior of sand is studied using triaxial shear tests. Dry funnel pluviation (DFP) and wet tamping (WT) are used to prepare the specimens. The results from instability lines and stress–strain curves indicate that the liquefaction resistance of specimens prepared with the DFP method is more than specimens reconstituted by the WT method.     

Optothermal analysis of polymer composites

A number of thermographic techniques under optical-radiation heating are described for the nondestructive evaluation of different kinds of fiber-filled polymer-based composites. Shallow delaminations within carbon-fiber reinforced laminates can be detected by this method under wide-area surface heating to 5 or 10° above ambient. A number of image-processing algorithms are described for improving the visibility of subsurface defects. Spot-heating techniques are presented for the characterization of fiber concentration, distribution, and orientation in carbon or steel fiber-filled composites. Particular emphasis is given to the possibility of mapping fiber-orientation properties at gradually deeper layers below the surface. These optothermal techniques appear to be a convenient tool for the inspection of opaque composites in terms of rapidity, lack of sample preparation requirement, and simplicity both in its implementation and in the interpretation of results.     

Aerobic Biodegradation of Acetylated Starch

Some acetylated starch samples with degrees of substitution varying from 0.03 to 1.6 are submitted to aerobic degradation by Bacillus amyloliquefaciens. The degradation is expressed by the concentration of reducing sugars evolved from the substrate, by the amylolytic activity and by the assessment of the CO₂ release resulting from the mineralization of the acetylated starch. With formation of exclusively glucose and maltose as control substrates, the hydrolysis is complete. For the samples with a low acetylation degree, the hydrolysis is slowed down as a result of inhibition by the acetyl groups. When the degree of acetylation is high, it becomes necessary to add inducers of acetylesterase activity. So, for acetylated starch with a degree of substitution of 1.6, the mineralization percentage increases up to 30% upon addition of isopropyl-β-D -thiogalactopyranoside.