Preparation and Evaluation of a Self-Nanoemulsifying Drug Delivery System Loaded with Heparin Phospholipid Complex

A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of heparin after oral administration, in which heparin was compounded with phospholipids to achieve better fat solubility in the form of heparin-phospholipid (HEP-Pc) complex. HEP-Pc complex was prepared using the solvent evaporation method, which increased the solubility of heparin in n-octanol. The successful preparation of HEP-Pc complex was confirmed by differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, NMR, and SEM. A heparin lipid microemulsion (HEP-LM) was prepared by high-pressure homogenization and characterized. HEP-LM can enhance the absorption of heparin after oral administration, significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT) in mice, and reduce fibrinogen (FIB) content. All these outcomes indicate that HEP-LM has great potential as an oral heparin formulation.     

Progressive NO2 Sensors with Rapid Alarm and Persistent Memory-Type Responses for Wide-Range Sensing Using Antimony Triselenide Nanoflakes

Antimony triselenide (Sb₂Se₃) nanoflake-based nitrogen dioxide (NO₂) sensors exhibit a progressive bifunctional gas-sensing performance, with a rapid alarm for hazardous highly concentrated gases, and an advanced memory-type function for low-concentration (<1 ppm) monitoring repeated under potentially fatal exposure. Rectangular and cuboid shaped Sb₂Se₃ nanoflakes, comprising van der Waals planes with large surface areas and covalent bond planes with small areas, can rapidly detect a wide range of NO₂ gas concentrations from 0.1 to 100 ppm. These Sb₂Se₃ nanoflakes are found to be suitable for physisorption-based gas sensing owing to their anisotropic quasi-2D crystal structure with extremely enlarged van der Waals planes, where they are humidity-insensitive and consequently exhibit an extremely stable baseline current. The Sb₂Se₃ nanoflake sensor exhibits a room-temperature/low-voltage operation, which is noticeable owing to its low energy consumption and rapid response even under a NO₂ gas flow of only 1 ppm. As a result, the Sb₂Se₃ nanoflake sensor is suitable for the development of a rapid alarm system. Furthermore, the persistent gas-sensing conductivity of the sensor with a slow decaying current can enable the development of a progressive memory-type sensor that retains the previous signal under irregular gas injection at low concentrations.     

LNG接收站火炬放空系统设计工况研究与分析

在液化天然气(LNG)接收站工程设计建设过程中，火炬系统的设计是保证LNG接收站安全生产的必要条件。以国内某LNG接收站为例，分析了LNG蒸发气(BOG)产生的因素和机理，及6种工况组合下火炬排放量的计算方法。结果表明：在工况1条件下与实际生产情况吻合良好，其对应的火炬气排放量约为142.7 t/h。在此基础上确定了：BOG支管管径为DN600,BOG总管的管径为DN900;被分离液滴的直径不大于600μm;火炬分液罐尺寸为?2.5 m×8.0 m;电加热器的功率为195 kW;火炬形式为封闭式地面火炬。研究结果可为今后LNG接收站项目火炬系统的处理能力及设备配置提供理论指导。     

Synthesis of nanopowders with low agglomeration by elaborating Φ values for producing Gd2O3-MgO nanocomposites with extremely fine grain sizes and high mid-infrared transparency

Refining ceramic microstructures to the nanometric range to minimize light scattering provides an interesting methodology for developing novel optical ceramic materials. In this work, we reported the fabrication and properties of a new nanocomposite optical ceramic of Gd₂O₃-MgO. The citric acid sol-gel combustion method was adopted to fabricate Gd₂O₃-MgO nanocomposites with fine-grain sizes, dense microstructures and homogeneous phase domains. Nanopowders with low agglomeration and improved sinterability can be obtained by elaborating Φ values. Further refining of the microstructure of the nanocomposites was achieved by elaborating the hot-pressing conditions. The sample sintered at 65 MPa and 1300 °C showed a quite high hardness value of 14.3 ± 0.2 GPa, a high transmittance of 80.3 %–84.7 % over the 3?6 μm wavelength range, due mainly to its extremely fine-grain size of Gd₂O₃ and MgO (93 and 78 nm, respectively) and high density.     

吉林油田低注入井吸水剖面施工工艺控制

本文对吉林油田低注入井五参数测井过程中遇到的一些问题进行分析,并相应提出一系列行之有效的解决方法。     

SND生物脱氮过程N_2O的产生与关键酶及其活性

废水生物脱氮是目前水处理中重要的去除含氮废水的方法。随着国内外学者的深入研究,一些新型的生物脱氮工艺被开发和应用到污水处理中,从而经济高效地去除废水中的含氮污染物,达到国家的排放标准。同步硝化反硝化(SND)是具有发展潜力的新型脱氮工艺,但在运行过程中不可避免地会产生N2O。N2O是最重要的三种温室气体之一,其温室效应约为CO2的300倍。因此,在注重SND的脱氮效率的同时,也应该关注其产生的气态物对大气环境的影响。文章阐述了SND脱氮过程中N2O产生的机理及相关酶,并分析了SND工艺过程中主要影响N2O释放量的工艺因素。     

Auto-registration of medium and high spatial resolution satellite images by integrating improved SIFT and spatial consistency constraints

Feature-based methods have been developed in the past decades for the registration of optical satellite images. However, it is still a challenging problem to handle well the registration between medium and high spatial resolution images due to the large difference of the spatial structural features and local details for the same objects. In this study, an automated co-registration technique is proposed that integrates an improved SIFT (I-SIFT) and a novel matching strategy called spatial consistency constraints (SCC) to cope with the large difference in spatial resolutions between the image pair. Three constraints on angle, distance, and ratio are introduced to re the initial matching features obtained by I-SIFT. Three groups of experiments were conducted to validate the effectiveness of the proposed method. The experiments used high resolution multispectral and panoramic SPOT 5/6 images and Landsat 5/8 orthorectification images. Experimental results show that the registration error lies in about 1 pixel of high-resolution images and demonstrate that the proposed I-SIFT-SCC approach is suitable for fine registration of optical satellite images from medium spatial resolution to high spatial resolution with resolution ratio up to 6.     

和成矿业洗矿系统改造实践

针对和成矿业井下原矿含泥量和含水量较大，且矿泥中存在绿泥石、高岭土等黏土类矿物，造成供矿系统粘堵严重，系统台时量仅为设计水平一半的问题，对原矿进行了洗矿工艺研究。通过洗矿工艺，将原矿中的矿块和矿泥分离，实现矿块和矿泥按粒度分选，彻底解决了供矿系统粘堵严重的问题，稳定了磨选系统给矿量。