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991.
992.
OBJECTIVE: To determine whether a significant association occurs between the presence of various periodontal diseases and recoverable infectious HIV-I in the saliva of injecting drug users. DESIGN: Five hundred and fifty-one injecting drug users were recruited from various programs associated with the Beth Israel Medical Center. Examiners were 'blinded' to the subject's HIV-I serostatus. A socio-economic and risk factors' survey was conducted and a complete oral examination, including periodontal disease indices was performed. Whole saliva and blood were collected for virus culture. MAIN OUTCOME MEASUREMENTS: Recovery of infectious HIV-I in saliva related to presence of periodontal diseases. RESULTS: Those HIV-I seropositive subjects with periodontal diseases did not differ from those HIV-I seropositive subjects without periodontal disease in mean age and immune status. Less than 1% of the HIV-I seropositive subjects had cultivable HIV-I in their saliva while it was present in 78% of PBMCs and 35% of the sera. There was no significant association between infectious HIV-I in saliva, serum, or PBMCs and any of the various periodontal diseases. CONCLUSIONS: The presence of periodontal disease in HIV-I seropositive injecting drug users does not appear to be a potential risk factor for infectious HIV-I in saliva, probably due to the various anti-viral components of saliva. 相似文献
993.
单片机系统的硬件抗干扰技术 总被引:2,自引:0,他引:2
本文讨论了单片机系统中干扰的特性和主要窜入渠道。提出应根据干扰的机理,有针对性地采取相应措施,才能得到良好的效果。文中从供电系统、过程通道、电路配置等方面讨论了硬件抗干扰的可能方法和工艺措施,并给出了相应的实用电路。 相似文献
994.
The effects of the partial substitution of element M(M=Cr,V,Mn,x=0.05;Zr,Ga,x=0.017;Si,x=0.15;Co,x=0.10)for Fe in samarium-iron-nitride Sm_2(Fe_(1-x)M_x)_(17)N_y compounds on their stabilitiesand Curie temperatures have been studied.It is found that Co,Ga can raise the Curie temperature of thecompounds.The initial decomposition temperatures cannot be raised significantly by all the studied elementsexcept Co.The result contradicts the formation enthalpy consideration.The final decomposition tempera-tures can be raised by all of the substitution elements.The effects of atmospheres on their decomposition be-havior were also studied.The results show that oxidation is the major reason for magnetic deterioration ofthe powder heated in air.Compared with nitrogen atmosphere,argon or vacuum helps to delay the decompo-sition of the compounds. 相似文献
995.
在机动车磁卡收费系统中,红外车辆分离子系统是一种重要设备,它是由平行等距红外线族构成的平面检测系统,其性能直接影响收费系统的正常运转。本文介绍该子系统的设计并对系统性能进行分析,得出:子系统采取相关检测技术后,不仅能有效地抑制外界干扰、噪声,还具有抗相邻红外信号干扰能力。 相似文献
996.
The insulin-like growth factor (IGF) signaling system includes the growth factors and their cell surface receptors, along with circulating IGF binding proteins (IGFBPs) that may alter and modulate the action of these neurotrophic hormones. These IGFBPs, along with IGFs and receptors, have been detected in various tissues including the brain. In this study, using polyclonal antibody to human IGFBP-1 or bovine IGFBP-2, we found that mouse muscle extracts contain similar-sized proteins that cross-react with these antibodies on Western immunoblots. After establishing that these antibodies reacted with the homologous murine IGFBPs, we performed immunocytochemistry to demonstrate the localization of IGFBP-1 at the neuromuscular junction, a model nicotinic, cholinergic synapse, as well as within intramuscular nerves. IGFBP-2, a distinct macromolecule, is present on the surface of muscle fibers and is not present within synapses or nerves. 相似文献
997.
998.
B Springer L Stockman K Teschner GD Roberts EC B?ttger 《Canadian Metallurgical Quarterly》1996,34(2):296-303
Previous studies have indicated that the conventional tests used for the identification of mycobacteria may (i) frequently result in erroneous identification and (ii) underestimate the diversity within the genus Mycobacterium. To address this issue in a more systematic fashion, a study comparing phenotypic and molecular methods for the identification of mycobacteria was initiated. Focus was given to isolates which were difficult to identify to species level and which yielded inconclusive results by conventional tests performed under day-to-day routine laboratory conditions. Traditional methods included growth rate, colonial morphology, pigmentation, biochemical profiles, and gas-liquid chromatography of short-chain fatty acids. Molecular identification was done by PCR-mediated partial sequence analysis of the gene encoding the 16S rRNA. A total of 34 isolates was included in this study; 13 of the isolates corresponded to established species, and 21 isolates corresponded to previously uncharacterized taxa. For five isolates, phenotypic and molecular analyses gave identical results. For five isolates, minor discrepancies were present; four isolates remained unidentified after biochemical testing. For 20 isolates, major discrepancies between traditional and molecular typing methods were observed. Retrospective analysis of the data revealed that the discrepant results were without exception due to erroneous biochemical test results or interpretations. In particular, phenotypic identification schemes were compromised with regard to the recognition of previously undescribed taxa. We conclude that molecular typing by 16S rRNA sequence determination is not only more rapid (12 to 36 h versus 4 to 8 weeks) but also more accurate than traditional typing. 相似文献
999.
BB Kragelund P H?jrup MS Jensen CK Schjerling E Juul J Knudsen FM Poulsen 《Canadian Metallurgical Quarterly》1996,256(1):187-200
Bovine acyl-coenzyme A binding protein is a four-helix bundle protein belonging to a group of homologous eukaryote proteins that binds medium and long-chain acyl-coenzyme A esters with a very high affinity. The three-dimensional structure of both the free and the ligated protein together with the folding kinetics have been described in detail for the bovine protein and with four new sequences reported here, a total of 16 closely related sequences ranging from yeasts and plants to human are known. The kinetics of folding and unfolding in different concentrations of guanidine hydrochloride together with equilibrium unfolding have been measured for bovine, rat and yeast acyl-coenzyme A binding protein. The bovine and rat sequences are closely related whereas the yeast is more distantly related to these. In addition to the three natural variants, kinetics of a bovine mutant protein, Tyr31 --> Asn, have been studied. Both the folding and unfolding rates in water of the yeast protein are 15 times faster than those of bovine. The folding rates in water of the two mammalian forms, rat and bovine, are similar, though still significantly different. A faster unfolding rate both for rat and the bovine mutant protein results from a lower stability of the native states of these. These hydrophobic regions, mini cores, have been identified in the three-dimensional structure of the bovine protein and found to be formed primarily by residues that have been conserved throughout the entire eukaryote evolution from yeasts to both plants and mammals as seen in the sample of 16 sequences. The conserved residues are found to stabilize helix-helix interactions and serve specific functional purposes for ligand binding. The fast one-step folding mechanism of ACBP has been shown to be a feature that seems to be maintained throughout evolution despite numerous differences in sequence and even dramatic differences in folding kinetics and protein stability. The protein study raises the question to what extent does the conserved hydrophobic residues provide a scaffold for an efficient one-step folding mechanism. 相似文献
1000.
文章重点阐述了在高职院校信息资源管理艰难的大环境下,我院信息资源管理软件开发使用的环境及过程,重点论述了管理软件的具有的特色及使用过程中遇到的问题。 相似文献