Binding and lysing of blood clots using MRX-408

RATIONALE AND OBJECTIVES: A thrombus-specific ultrasound contrast agent, MRX-408, has been developed recently. This agent consists of phospholipid-coated microbubbles with a ligand capable of targeting the GPIIb/IIIa receptor, thereby allowing the microbubbles to bind with thrombi rich in activated platelets. In vitro and in vivo animal experiments have been conducted to examine imaging enhancement and sonothrombolysis using this agent compared with a nontargeted agent. METHODS: For clot binding, blood-smeared slides were incubated with microbubbles and examined under a light microscope. Change in backscatter signals from the blood clots after binding was examined by both an ultrasound scanner and two single-element transducers arranged in a transmitter-receiver pair. For clot lysis, either 1-MHz or 20-KHz ultrasound was used to enhance the lysing effects of MRX-408 with or without urokinase. RESULTS: Evidence of binding was demonstrated under a microscope. In vitro experiments showed that the "acoustic signature", or properties, of blood clots changed after binding. Clots became more echogenic and nonlinear. In vivo fundamental ultrasound imaging confirmed that as a result of binding, blood clots were more visible, the area of detection was improved, and shadowing behind clots was more noticeable. Under 1-MHz ultrasound and 30 minutes of treatment, lysis efficiency reached 34% with MRX-408, whereas there was no visible clot lysis with saline. CONCLUSION: The results of these preliminary studies show that as a contrast agent, MRX-408 enhanced clots under ultrasound imaging and facilitated sonothrombolysis with or without thrombolytic drugs.     

舒曼钢琴音乐的双重性格特征

德国作曲家罗伯特·舒曼是十九世纪上半叶欧洲音乐文化史上最突出的人物之一。在他的钢琴音乐创作中,深刻地反映出浪漫主义音乐的特点。舒曼设计了一个想象中的“大卫同盟”,其中有两名核心盟员,一个叫弗洛列斯坦,另一个叫埃塞比乌斯。前者性格热情奔放,锋芒毕露;后者则文雅娴静,富于幻想,实际上这就是舒曼本人性格中的两个侧面。这种双重性格特征在舒曼的钢琴音乐中得到充分展示,并成为舒曼钢琴音乐的艺术特征之一。     

Analytical modeling of the periodic nonlinearity in heterodyne interferometry

The periodic nonlinearity that arises from nonideal laser sources and imperfections of optical components limits the accuracy of displacement measurements in heterodyne interferometry at the nanometer level. An analytical approach to investigating the nonlinearity is presented. Frequency mixing, polarization mixing, polarization-frequency mixing, and ghost reflections are all included in this investigation. A general form for the measurement signal, including that of the distortions, is given. The analytical approach is also applicable to homodyne interferometry.     

Highly efficient, widely tunable, 10-Hz parametric amplifier pumped by frequency-doubled femtosecond Ti:sapphire laser pulses

We report a 10-Hz, highly efficient, widely tunable (from the visible to the IR), broadband femtosecond optical parametric generator and optical parametric amplifier (OPA) in BBO, LBO, and CBO crystals pumped by the frequency-doubled output of a regeneratively amplified Ti:sapphire laser at 400 nm. The output of the system is continuously tunable from 440 nm to 2.5 mum with a maximum overall efficiency of ~25% at 670 nm and an optical conversion efficiency of more than 36% in the OPA stage. The effects of the seed beam energy, the type of the crystal and the crystal length, and the pumping energy of the output of the OPA, such as the optical efficiency, the bandwidth, the pulse duration, and the group velocity mismatch between the signal and the idler and between the seeder and the pump, are investigated. The results provide useful information for optimization of the design of the system.     

Empirical equations for the principal refractive indices and column angle of obliquely deposited films of tantalum oxide, titanium oxide, and zirconium oxide

Values of the transmittance T(s) and the phaseretardation D were recorded in situ at two angles duringthe growth of thin films of tantalum oxide, titanium oxide, andzirconium oxide for deposition angles theta(nu) in the range40 degrees -70 degrees . Column angles for the same films were determinedex situ from scanning electron microscopy photographs ofdeposition-plane fractures. We show that the experimental columnangles are smaller than the corresponding values predicted by thetangent-rule equation psi = tan(-1)(0.5 tan theta(nu)) and that the experimental values fit a modifiedform of the equation psi = tan(-1)(E(1) tan theta(nu)) where E(1) is less than 0.5. We also show that theprincipal refractive indices are represented well by quadraticfunctions of the deposition angle, for example, n(1)(theta(nu)) = A(0) + A(2) theta(nu)(2).     

三相Δ接法同步发电机带整流负载特性的数值仿真

基于同步发电机理论,建立了同步发电机三相定子绕组三角形接法带整流负载系统的数学模型,文中计及高次谐波气隙磁场和整流元件压降的影响,利用一种数值算法,对不同整流负载的特性进行仿真,给出它们的仿真波形,并进行比较。     

双股射流壁面脉动压强与近壁紊动流速相关与频谱特性

本文用多通道动态压力检测系统和二维激光测速仪对在单股和双股射流作用下,水垫塘底板脉动压强与近壁脉动流速的相关,功率谱和紊动比尺进行了测试研究。实测表明,双股射流形成的动水扩建在塘底水平方向的脉动使得双股射流在第二冲击点下游的脉动量特性与单股射流不同：前者的水平脉动速度与脉动压强的互相关系数较后者明显增大,且水平脉动速度和脉动压强的功率谱具有大致相同的优势频率。单股和双股射流塘底脉动压强系数与近壁紊     

黄河下游防洪减灾效益分析

由于黄河多泥沙的特性和特殊的自然条件,黄河下游河道在历史上决口频繁。人民治黄５０年来,黄河下游的防洪减灾措施确保了黄淮海太平原的安全,取得了巨大的社会经济效益。,采用“实际发生年法”对黄河下游防洪减灾效益进行了分析。结果表明,人民治黄以来,黄河下游防洪工程减免大堤决口、减少滩地淹没、减少凌汛决口及河道淤积所取得的直接经济效益分析另３４００．１、６５．８、１２０．０、４５．０亿元,由于黄河问题的复杂     

High-performance aromatic polyimide fibres

A new polyimide has been synthesized from 3,3,4,4-biphenyltetracarboxylic dianhydride (BPDA) and 2,2-dimethyl-4,4-diaminobiphenyl (DMB). A high-strength, high-modulus, high-temperature fibre has been developed from this polyimide via a dry-jet wet spinning method. The tensile strength of BPDA-DMB fibres is 3.3 GPa and the tensile modulus is around 130 GPa. The compressive strength of the fibres has been investigated through a tensile recoil test (TRT), while the fibre morphology after compression has been studied via polarized light microscopy (PLM) and scanning electron microscopy (SEM). From the TRT measurements, we have observed that the compressive strength of this fibre is 665 (±5) MPa, which is higher than those of other aromatic polymer fibres. The effect of fibre diameter on the compressive strength of BPDA-DMB fibres is not substantial. The critical compressive strain for this fibre at which the kink bands start appearing under the observation of PLM is at 0.51–0.54%. Subglass relaxation processes have been observed and the measure of an apparent relaxation strength may serve as one of the factors which significantly affect the compressive strength of the fibres. Tensile tests of pre-compressed fibres reveal a continuous loss in tensile strength (up to 30%) with increasing the compressive strain (up to 2.6%). PLM and SEM observations show that during the compression BPDA-DMB fibres form regularly-spaced kink bands at ±60 ° (±2 °) with respect to the fibre axis. The kink band density initially increases with the compressive strain, and reaches a maximum at around 1.1%. Further increase of the compressive strain decreases this density due to the merge of the neighbouring bands. The size of kink bands also correspondingly increases within this compressive strain region. The morphological observation via SEM implies the existence of a skin-core structure and microfibrillar texture which are common features in polymer fibres.