Inhibition of TNFalpha attenuates infarct volume and ICAM-1 expression in ischemic mouse brain

The family physician occupies a front-line position in the detection and treatment of emotional problems and psychiatric illnesses. The practice pattern of the family physician necessitates an efficient, effective model of psychotherapy The BATHE technique is a brief psychotherapeutic method that addresses the patient's background issues, affect and most troubling problem. The emphasis of the interview then shifts to how the patient is handling the problem and a demonstration of empathy by the physician. Some of the challenges in psychotherapy are presented, and cases in which the BATHE technique was used are described.     

Precise Molecular Engineering of Photosensitizers with Aggregation‐Induced Emission over 800 nm for Photodynamic Therapy

Owing to efficient singlet oxygen (¹O₂) generation in aggregate state, photosensitizers (PSs) with aggregation‐induced emission (AIE) have attracted much research interests in photodynamic therapy (PDT). In addition to high ¹O₂ generation efficiency, strong molar absorption in long‐wavelength range and near‐infrared (NIR) emission are also highly desirable, but difficult to achieve for AIE PSs since the twisted structures in AIE moieties usually lead to absorption and emission in short‐wavelength range. In this contribution, through acceptor engineering, a new AIE PS of TBT is designed to show aggregation‐induced NIR emission centered at 810 nm, broad absorption in the range between 300 and 700 nm with a large molar absorption coefficient and a high ¹O₂ generation efficiency under white light irradiation. Further, donor engineering by attaching two branched flexible chains to TBT yielded TBTC8 , which circumvented the strong intermolecular interactions of TBT in nanoparticles (NPs), yielding TBTC8 NPs with optimized overall performance in ¹O₂ generation, absorption, and emission. Subsequent PDT results in both in vitro and in vivo studies indicate that TBTC8 NPs are promising candidates in practical application.     

航管一次雷达抗风电场干扰目标检测方法

近年来,全球风力发电装机容量呈指数型增长。然而,现有航管一次雷达的动目标检测(Moving Target Detector, MTD)技术无法抑制具有非零频成分的风电场杂波,可能导致目标遮蔽和虚警率上升。针对此问题,该文提出了一种在风电场杂波下航管一次雷达的目标检测方法。该方法在MTD前端设置风电场杂波抑制器。在该抑制器中首先估计雷达回波每个距离单元的谱中心,并把所有距离单元的谱中心移到零频。其次利用类似于对消固定杂波的方法对消目标回波,而具有较宽频谱宽度的风电场杂波经对消后仍有大部分的能量剩余。然后采用恒虚警率(Constant False Alarm Rate, CFAR)检测确定杂波所在的距离单元,并剔除待检测数据中所有杂波单元,解决了风电场杂波进入非零频多普勒滤波器可能导致当前航管一次雷达MTD检测性能急剧恶化的问题。实验结果表明该方法对风电场杂波强度不敏感,有效地消除了杂波对目标的遮蔽现象并控制了由杂波引起的虚警率上升。     

PS,LS和煤油体系的界面张力

本文以石油磺酸盐(PS)、木质素磺酸盐(LS)和煤油体系为对象,研究了PS/LS比、盐度、醇、Na_2SiO_3及聚合物对体系界面张力(IFT)的影响,探讨了PS与各组分间的相互作用,结果发现,在一定盐度和混合醇(正丁醇+异丙醇)浓度下,PS/LS>0.3/0.7时,体系可形成中相微乳液,IFT值达1×10~(-3)mN/m左右;LS和聚合物的存在使IFT升高;在表面活性剂驱油体系中,可用廉价的LS部分代替PS。     

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

BACKGROUND: Carcinoma of the breast is characterized by a variable course with prognosis dependent on disease stage at presentation. Paradoxically, some patients with early malignancy demonstrate disease progression within a short time. The role of tumor markers in the management of carcinoma of the breast is controversial. While CA15-3 is the most widely used tumor marker in carcinoma of the breast, its role in the management of patients with early disease is controversial. STUDY DESIGN: Since 1986, all patients presenting to our unit with carcinoma of the breast have had serial CA15-3 levels measured. This study evaluates the role of serial CA15-3 levels in the management of a consecutive series of 168 patients with Stage I disease at presentation. RESULTS: The mean preoperative CA15-3 levels at presentation were significantly elevated in patients with Stage I disease compared with patients with benign disease. Sixteen patients had either locoregional (five patients) or metastatic recurrence (11 patients). CA15-3 levels were not elevated in patients with locoregional disease and were significantly elevated in patients with bony metastases and gave a mean lead time of 6.3 months over bone scintigraphy. CONCLUSIONS: Serial CA15-3 measurements are an efficient and cost-effective method of monitoring disease progression and have advantages over conventional investigations in patients with early carcinoma of the breast.     

长输管线变电所备用电源自动投入系统的改造

根据管道储运公司下属的各变电所目前的运行方式以及备用电源自动投入系统(以下简称“备自投”)的运行情况，指出了备自投使用中的不足之处，并通过增加对应断路器的辅助触点来完善备自投，使变电所运行更加可靠。     

离子型稀土矿原地浸析采场的监测

叙述了我国离子型稀土矿原地浸析采矿时的采场监测系统的重要性, 介绍了检测系统的布置原则、监测方法及监测结果分析与应用, 对离子型稀土矿原地浸析采矿方法的推广与应用具有实际的指导意义。     

Discriminative Hough context model for object detection

This paper presents a novel Hough context model for detecting and localizing instances of a certain object class. In particular, our approach detects the object in parameter space by applying Hough voting in context. First, in Hough context, the features around object center or a point in parameter space are sampled and organized in context sense respectively for both training images and test images. Then a parametric discriminant function is constructed based on the Hough context. Such function scores the existence likelihood of object centers in parameter space. Finally, we formulate the training process of this discriminative model as a structure learning problem, which has already been well solved. Compared with the ISM-related methods that the voting is performed by the features independently, the core contribution of our method is that the voting based on context information is available. The experiments on several popular and challenging object datasets (i.e., ETHZ Shape, UIUC Cars, and PASCAL VOC 2007) demonstrate that the detection accuracy can be improved and the voting speed are impressively accelerated via using Hough context.     

Rijke型燃烧装置结构特性对声波自激的影响

分析了 Rijke型燃烧器结构对声波产生的影响 ,根据理论分析及实验结果得出在较大型化的实验装置上实现声波作用燃烧的可能性和燃烧器结构对声激发的影响规律 ,以及减少燃烧器内部声能损失 ,促进和维持声能自激、转换的方法 ,为 Rijke型燃烧器走向大型化、实用化提供了理论及实验依据。     

Dispersion deposition of metal — Particle composites and the evaluation of dispersion deposited nickel — Lanthanum nickelate electrocatalyst for hydrogen evolution

A method for the preparation of high surface area coatings and its application towards fabrication of prospective composite electrocatalysts for hydrogen evolution is proposed. Exploratory studies with such a composite, (Ni/LaNiO₃), as a hydrogen electrode in alkaline solutions indicate that it is a more active electrocatalyst than sintered or electrodeposited nickel. The electrocatalytic properties were found to be a strong function of the deposition parameters as well as of the history of the oxide powder.