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91.
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Jia-Shun Liu Yi-Kun Zhang Hui Tang Li-Bo Zhang Ben-Qiang Yang Ying Yan Li-Min Luo Yang Chen 《核技术(英文版)》2021,32(8):23-33
Tomographic perfusion imaging is a significant imaging modality for stroke diagnosis.However,the low rotational speed of the C-arm(6-8 s per circle)is a chal-le... 相似文献
94.
Rongrong Luo Lei Chen Xingxing Song Xin Zhang Wenhao Xu Dongyang Han Jianyu Zuo Wen Hu Yan Shi Yajie Cao Runwen Ma Chengcheng Liu Changlin Xu Zixin Li Xun Li 《International journal of molecular sciences》2022,23(15)
Gonadotropin-inhibitory hormone (GnIH) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis and reproduction. However, whether GnIH is a molecular signal link of metabolism and the reproductive system, and thus, regulates reproductive activity as a function of the energy state, is still unknown. In the present study, we investigated the involvement of GnIH in glycolipid metabolism and reproduction in vivo, and in the coupling between these two processes in the testis level. Our results showed that chronic intraperitoneal injection of GnIH into male mice not only increased food intake and altered meal microstructure but also significantly elevated body mass due to the increased mass of liver and epididymal white adipose tissue (eWAT), despite the loss of testicular weight. Furthermore, chronic intraperitoneal administration of GnIH to male mice resulted in obesity-related glycolipid metabolic derangements, showing hyperlipidemia, hyperglycemia, glucose intolerance, and insulin resistance through changes in the expression of glucose and lipid metabolism-related genes in the pancreas and eWAT, respectively. Interestingly, the expression of GnIH and GPR147 was markedly increased in the testis of mice under conditions of energy imbalance, such as fasting, acute hypoglycemia, and hyperglycemia. In addition, chronic GnIH injection markedly inhibited glucose and lipid metabolism of mice testis while significantly decreasing testosterone synthesis and sperm quality, inducing hypogonadism. These observations indicated that orexigenic GnIH triggers hyperphagia-induced obesity-related metabolic derangements and hypogonadism in male mice, suggesting that GnIH is an emerging candidate for coupling metabolism and fertility by involvement in obesity and metabolic disorder-induced reproductive dysfunction of the testes. 相似文献
95.
根据作者提出的血流动力学参数计算公式,研究了不同年令和不同血压下血流动力学参数的变化从中得出外周阻力的增高是高血压最主要的危险因素。并经理论分析和临床实测证实了这个结论。 相似文献
96.
In order to reduce the computation of complex problems, a new surrogate-assisted estimation of distribution algorithm with
Gaussian process was proposed. Coevolution was used in dual populations which evolved in parallel. The search space was projected
into multiple subspaces and searched by sub-populations. Also, the whole space was exploited by the other population which
exchanges information with the sub-populations. In order to make the evolutionary course efficient, multivariate Gaussian
model and Gaussian mixture model were used in both populations separately to estimate the distribution of individuals and
reproduce new generations. For the surrogate model, Gaussian process was combined with the algorithm which predicted variance
of the predictions. The results on six benchmark functions show that the new algorithm performs better than other surrogate-model
based algorithms and the computation complexity is only 10% of the original estimation of distribution algorithm. 相似文献
97.
本工作测定了不同温度下硫酸高铈与对二甲苯反应的速率常数及表观活化能Ea= 111.5kJ·m ol- 1。在动力学测定的的基础上确定了此反应的速率方程为d[PTAL]/dt= k[PX][Ce(IV)] 相似文献
98.
用姐妹染色单体交换(SCE)作为指标,研究了~(60)Coγ射线辐照及NADH-PMS(吩嗪硫酸甲酯)系统中产生的超氧阴离子自由基(0_2~(·-))对胎儿脐血淋巴细胞染色体的损伤作用,及活性氧清除剂SOD和甘露醇的保护作用。结果显示γ射线及0_2~(·-)都能诱发细胞SCE频率显著升高,且存在一定的剂量-效应关系。SOD及甘露醇对0_2~(·-)诱发的损伤有明显的保护作用。 相似文献
99.
Yao Cai Hui-Dong Liu Zhong-Wei Hu Qiang Wan Chang Luo Hao Chen Yan Liu Yan-Ming Chen Qing-Song Mei Bing Yang 《核技术(英文版)》2018,(1)
Nanocomposite Cr C/hydrogenated amorphous carbon(nc-CrC/a-C:H) coatings were deposited by a hybrid beams system comprised of a hollow cathode ion source and a cathodic arc ion-plating unit with varying H_2 flow rates. The influences of H_2 flow rates on the morphologies, microstructures, and properties of the coatings were systematically studied. The morphologies and microstructures of the coatings were characterized by SEM, AFM, XPS, Raman spectroscopy, GIXRD, and HRTEM. The mechanical and tribological properties were measured by a nano-indenter, scratch tester, and ball-ondisk tribometer. The wear tracks were evaluated using 3D profilometer, optical microscope, and EDS analysis. It has been found that a moderate H_2 flow rate can effectively smooth the surface, enlarge the fraction of a sp~3 bond, and improve the properties. The coating exhibits the highest hardness and elastic modulus at the H_2 flow rate of 40 sccm. A superior combination of adhesion strength,friction coefficient, and wear resistance can be achieved at the H_2 flow rate of 80 sccm. 相似文献
100.