Preparation of Lung-Targeting,Emodin-Loaded Polylactic Acid Microspheres and Their Properties

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been identified to have the potential to improve lung fibrosis and lung cancer. To avoid the liver and kidney toxicities and the fast metabolism of emodin, emodin-loaded polylactic acid microspheres (ED-PLA-MS) were prepared and their characteristics were studied. ED-PLA-MS were prepared by the organic phase dispersion-solvent diffusion method. By applying an orthogonal design, our results indicated that the optimal formulation was 12 mg/mL PLA, 0.5% gelatin, and an organic phase:glycerol ratio of 1:20. Using the optimal experimental conditions, the drug loading and encapsulation efficiencies were (19.0 ± 1.8)% and (62.2 ± 2.6)%, respectively. The average particle size was 9.7 ± 0.7 μm. In vitro studies indicated that the ED-PLA-MS demonstrated a well-sustained release efficacy. The microspheres delivered emodin, primarily to the lungs of mice, upon intravenous injection. It was also detected by microscopy that partial lung inflammation was observed in lung tissues and no pathological changes were found in other tissues of the ED-PLA-MS-treated animals. These results suggested that ED-PLA-MS are of potential value in treating lung diseases in animals.     

膨润土对Pb~(2+)的吸附及铝的影响研究

研究膨润土对水溶液中铅的吸附特性以及铝对铅吸附的影响。通过各组吸附实验,建立膨润土对水溶液中铅离子的吸附最佳条件,天然膨润土对铅的吸附平衡时间约为60 min,其吸附符合一级动力学方程;铅吸附最适p H=9;天然膨润土对水溶液中铅离子的吸附规律符合Freundlich等温方程和Langmuir等温方程,呈显著相关性;加入少量铝离子时,吸附除铅能力增强,但继续增加铝浓度,去除能力降低,该现象主要通过铝盐水解所致的p H变化起调节作用,电中和作用不明显。     

Powder Size Influence on Tensile Properties and Porosity for PM Ti_2AlNb Alloy Prepared by Hot Isostatic Pressing

Pre-alloyed powder of Ti_2AlNb alloy was prepared by electrode induction gas atomization method, and the powder was screened into fi ve kinds of powder size distribution. Fully dense Ti_2AlNb alloy was prepared by powder metallurgy(PM) using hot isostatic pressing. The properties of pre-alloyed powder and PM Ti_2AlNb alloy were tested. Results show that mean grain size of PM Ti_2AlNb alloy is infl uenced by powder particle size, but particle size has no signifi cant infl uence on tensile properties. Finer Ti_2AlNb powder has low Argon gas bubble ratio and high oxygen content, and poor fl owability of fi ner powder increases the degree of diffculty during degassing. As a result, big pores( 50 μm) are observed in PM Ti_2AlNb alloy prepared by fi ner powder and cause plasticity loss of tensile properties. In order to get a better comprehensive properties of PM Ti_2AlNb alloy, powder with an average size(～ 100 μm) is suggested.     

Quench Sensitivity of AA7N01 Alloy Used for High-Speed Train Body Structure

JOM - The quench sensitivity of AA7N01 aluminum alloy used for high-speed train body structure was investigated by end-quenching test, time–temperature-transformation curves simulation,...     

浅谈桥面铺装层裂缝产生的原因与修补措施

近年来,由于高速公路的损坏而导致的交通事故越来越多,所以逐渐引起了人们的重视。水泥混凝土桥面板破损往往是面积最大的、也是最严重的,其他比较常见的病害有桥面铺装层破损、开裂、错台、麻面和磨光等。     

可持续性设计与高层建筑设计的相关问题探讨

由于高层建筑的结构特点有别于普通建筑,使得它在进行设计时面临着更多的难题。针对这一问题,笔者从可持续发展的角度,对可持续设计和高层建筑设计之间的相关问题进行了一系列探讨。     

iopeNet系统人机交互产品介绍

iopeNet系统产品分为建筑内部和子系统连接的核心模块、可自由定制的iopeNet人机交互接口以及通过互联网连接到云端的iopeNet云服务等几部分。本文主要介绍iopeNet智能建筑管理系统中的人机交互接口部分,包括iopeNet系统操作界面、iopeNet系统操作台以及itpeNet标准配电箱内板。在系统安装使用过程中提供便捷的设备安装和友好的人机交互界面。     

基于Fuzzy理论的产品UE量化分析

通过建立用户体验模型,得到丰富的体验数据,必须对其进行量化分析,Fuzzy数学理论为该数据的分析提供了模糊评判的标准,使产品设计部门更直观地了解消费者的体验。     

Preface

Evolutionary Algorithms(EAs)mimicking the principles of natural evolution can be used as powerful search and optimization methods.These Evolutionary Optimization methods are superior to traditional optimization methods especially in situations where gradient information is not readily available.EAs are generic and robust optimization methods since they do not make any assumption about the underlying search space.This is clearly evident by the success of EAs in a diverse range of real-world applications.T...