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61.
Cover Picture: Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential (ChemMedChem 21/2016) 下载免费PDF全文
62.
Hanna Mannell Petra Kameritsch Heike Beck Alexander Pfeifer Ulrich Pohl Kristin Pogoda 《International journal of molecular sciences》2022,23(1)
The gap junction protein connexin 43 (Cx43) is associated with increased cell migration and to related changes of the actin cytoskeleton, which is mediated via its C-terminal cytoplasmic tail and is independent of its channel function. Cx43 has been shown to possess an angiogenic potential, however, the role of Cx43 in endothelial cell migration has not yet been investigated. Here, we found that the knock-down of Cx43 by siRNA in human microvascular endothelial cells (HMEC) reduces migration, as assessed by a wound assay in vitro and impaired aortic vessel sprouting ex vivo. Immunoprecipitation of Cx43 revealed an interaction with the tyrosine phosphatase SHP-2, which enhanced its phosphatase activity, as observed in Cx43 expressing HeLa cells compared to cells treated with an empty vector. Interestingly, the expression of a dominant negative substrate trapping mutant SHP-2 (CS) in HMEC, via lentiviral transduction, also impaired endothelial migration to a similar extent as Cx43 siRNA compared to SHP-2 WT. Moreover, the reduction in endothelial migration upon Cx43 siRNA could not be rescued by the introduction of a constitutively active SHP-2 construct (EA). Our data demonstrate that Cx43 and SHP-2 mediate endothelial cell migration, revealing a novel interaction between Cx43 and SHP-2, which is essential for this process. 相似文献
63.
Recent developments in the formulation of detergents have been driven by a strong consumer demand for natural and biodegradable products. Detergent manufacturers responded to this demand with corresponding products and advertising slogans such as “fully biodegradable”, “natural” or even “double natural” to oust their competitors. In a detergent formulation, starch- derived products can in principle be used for the following purposes: as the hydrophilic head group in surfactants, as the starting material for (poly)carboxylate co-builders and as the backbone of bleaching activators. Non-ionic classical surfactants can be replaced by alkylpolyglucosides (APGs), a class of products completely based on renewable resources such as glucose and fatty alcohols derived from natural fatty acids. Sodium tripolyphosphate (STPP), the product responsible for the eutrophication of surface waters, can be substituted by a combination of an inorganic zeolite and highly oxidised starch (dicarboxylic starch) or by citrate. Acetylated polyols derived from hydrogenated carbohydrates such as sorbitol can take over the function of the petrochemically-based tetraacetyl ethylene diamine (TAED) used as activator to allow perborate bleaching at lower washing temperatures. 相似文献
64.
Joakim Norn 《火与材料》1996,20(3):133-143
Nailed joints with wood members were exposed simultaneously to standard fire and constant load. Different loads were applied in the range of 0.1 to 0.6 of the estimated failure load at normal temperature. Measurements of the rate of charring and the temperature were used to determine the temperature profiles and further to estimate the reduction in the strength properties. The test results are compared with calculations based on the theory of K. W. Johansen. Three different relations between the reduction of embedding strength and the temperature were investigated. For one of these relations, the theory agrees well with the results obtained in the fire tests. The results of the calculations also show that there is a considerable reduction of the embedding strength during the first period of fire. 相似文献
65.
66.
Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field 总被引:1,自引:0,他引:1
Topp E Monteiro SC Beck A Coelho BB Boxall AB Duenk PW Kleywegt S Lapen DR Payne M Sabourin L Li H Metcalfe CD 《The Science of the total environment》2008,396(1):52-59
Municipal biosolids are a source of nutrients for crop production. Beneficial Management Practices (BMPs) can be used to minimize the risk of contamination of adjacent water resources with chemical or microbial agents that are of public or environmental health concern. In this field study, we applied biosolids slurry at a commercial rate using either subsurface injection or broadcast application followed by incorporation. Precipitation was simulated at 1, 3, 7, 22, 36 and 266 days post-application on 2 m2 microplots to evaluate surface runoff of 9 model pharmaceuticals and personal care products (PPCPs), atenolol, carbamazepine, cotinine, gemfibrozil, naproxen, ibuprofen, acetaminophen, sulfamethoxazole and triclosan. In runoff from the injected plots, concentrations of the model PPCPs were generally below the limits of quantitation. In contrast, in the broadcast application treatment, the concentrations of atenolol, carbamazepine, cotinine, gemfibrozil, naproxen, sulfamethoxazole and triclosan on the day following application ranged from 70-1477 ng L− 1 in runoff and generally declined thereafter with first order kinetics. The total mass of PPCPs mobilized in surface runoff per m2 of the field ranged from 0.63 µg for atenolol to 21.1 µg for ibuprofen. For ibuprofen and acetaminophen, concentrations in runoff first decreased and then increased, suggesting that these drugs were initially chemically or physically sequestered in the biosolids slurry, and subsequently released in the soil. Carbamazepine and triclosan were detected at low concentrations in a runoff event 266 days after broadcast application. Overall, this study showed that injection of biosolids slurry below the soil surface could effectively eliminate surface runoff of PPCPs. 相似文献
67.
Karl Beck und Josef Schormüller 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1937,74(5):369-382
Zusammenfassung Frühere Untersuchungen über das Fleischeiweiß verschiedener Tiere wurden unter Verwendung colorimetrischer Verfahren nachgeprüft. Am Beispiel des Pferdefleisches konnte die von Beck und Mitarbeitern erhobene Feststellung bestätigt werden, daß die Hydrolysenprodukte der Fleischfaser sowie die durch Harnstoffextraktion aus Fleisch dargestellten Grundtypen: Extrakt- und Fasereiweiß weitgehend chemisch gleiche Zusammensetzung aufweisen.Neu aufgenommene Untersuchungen dienten dem Zweck, die aus dem Muskelfleisch dargestellten Proteine nach weiteren Gesichtspunkten zu prüfen und Grundlagen für die Differenzierung der fraglichen Eiweißstoffe auf biologischem Wege zu schaffen.Colorimetrische Bestimmung von Arginin, Tyrosin und Tryptophan, Ermittlung des Stickstoffgehaltes und Adsorption von Jod ergab für beide Proteinarten weitgehend übereinstimmende Werte. Es gelang, die Fleischeiweißstoffe frei von wesentlichen Mengen an Mineralstoffen darzustellen und die gegenteiligen Befunde der Literatur zu klären.Es wird ein Verfahren beschrieben, welches gestattet, die Einzelfraktionen der denaturierten Fleischproteine frei von Fremdstoffen in Lösung zu bringen. Die Eigenschaften der dabei erhaltenen, beständigen Lösungen werden untersucht in Hinblick auf ihre Verwendung zu immunbiologischen, demnächst veröffentlichten Untersuchungen. 相似文献
68.
Jeffrey Beck Richard Scritchfield Billy Sullivan Jamie Teherani Chang-Feng Wan Mike Kinch Martha Ohlson Mark Skokan Lewis Wood Pradip Mitra Mike Goodwin Jim Robinson 《Journal of Electronic Materials》2009,38(8):1579-1592
The operation of the mid-wave infrared (MWIR) HgCdTe cylindrical electron injection avalanche photodiode (e-APD) is described.
The measured gain and excess noise factor are related to the collection region fill factor. A two-dimensional diffusion model
calculates the time-dependent response and steady-state pixel point spread function for cylindrical diodes, and predicts bandwidths
near 1 GHz for small geometries. A 2 μm diameter spot scan system was developed for point spread function and crosstalk measurements at 80 K. An electron diffusion
length of 13.4 μm was extracted from spot scan data. Bandwidth data are shown that indicate bandwidths in excess of 300 MHz for small unit
cells geometries. Dark current data, at high gain levels, indicate an effective gain normalized dark density count as low
as 1000 counts/μs/cm2 at an APD gain of 444. A junction doping profile was determined from capacitance–voltage data. Spectral response data shows
a gain-independent characteristic. 相似文献
69.
C. A. D. Leguy P. Beck P. Gauger L. E. J. Beck U. Limper 《Microgravity science and technology》2014,26(2):111-117
The investigation of systemic blood pressure (BP) responses under partial-g conditions is of particular importance with respect to post-space-flight orthostatic intolerance. In this study, changes in vessel diameter and wall distension of the common carotid artery (CCA) were assessed under graded gravity. Measurements were performed on 8 healthy subjects in standing position under lunar (0.16 g), Martian (0.38 g), 1.0 g and hypergravity (1.8 g) during partial-g parabolic flights. Data are reported as means ± SE estimated by linear mixed effects modeling. The CCA diameter was significantly enlarged under Martian and lunar-g (6.55 ± 0.2 and 6.54 ± 0.2 mm; p < 0.001 each) with respect to 1.0 g (6.39 ± 0.2 mm). The CCA distension showed significant enlargement under Martian-g (622 ± 91μm) with respect to 1.0 g (603 ± 82μm; p < 0.05). Furthermore, the distension was significantly lower under hyper-g with respect to 1.0 g (550 ± 88μm; p < 0.001). These results show that rapid changes of gravitational stress induce significant modifications of hemodynamic parameters reflected in the CCA vessel wall diameter and distension. The increased vessel wall diameter under partial-g is likely due to the rise in mean BP at the CCA level caused by the absence of hydrostatic pressure and may trigger the baroreflex to maintain homeostatis. We can assume that the increase in distension during the partial-g phase originates from a larger stroke volume and enhanced BP reflections. Furthermore, this study demonstrates the reliability of functional high resolution vascular ultrasound technique during parabolic flights. 相似文献
70.
G. Xiong R. Shao S. J. Peppernick A. G. Joly K. M. Beck W. P. Hess M. Cai J. Duchene J. Y. Wang W. D. Wei 《JOM Journal of the Minerals, Metals and Materials Society》2010,62(12):90-93
Photoelectron emission microscopy (PEEM) is a versatile technique that can image a variety of materials including metals, semiconductors and even insulators. Under favorable conditions the most advanced aberration corrected instruments have a spatial resolution approaching 2 nm. Although PEEM cannot compete with transmission or scanning electron microscopies for ultimate resolution, the technique is much gentler and has the unique advantage of imaging structure as well as electronic and magnetic states on the nanoscale. Since the image contrast is derived from spatial variations in electron photoemission intensity, PEEM is ideal for interrogating both static and dynamic electronic properties of complex nanostructured materials. Here, we review the key principles and contrast mechanisms of PEEM and briefly summarize materials applications of PEEM. 相似文献