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81.
Maria Smolle Stefan Uranitsch Armin Gerger Martin Pichler Johannes Haybaeck 《International journal of molecular sciences》2014,15(8):13993-14013
The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide. 相似文献
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Daniel Ritzberger Johannes Höflinger Zhang Peng Du Christoph Hametner Stefan Jakubek 《International Journal of Hydrogen Energy》2021,46(21):11878-11893
In order to mitigate the degradation and prolong the lifetime of polymer electrolyte membrane fuel cells, advanced, model-based control strategies are becoming indispensable. Thereby, the availability of accurate yet computationally efficient fuel cell models is of crucial importance. Associated with this is the need to efficiently parameterize a given model to a concise and cost-effective experimental data set. A challenging task due to the large number of unknown parameters and the resulting complex optimization problem. In this work, a parameterization scheme based on the simultaneous estimation of multiple structured state space models, obtained by analytic linearization of a candidate fuel cell stack model, is proposed. These local linear models have the advantage of high computational efficiency, regaining the desired flexibility required for the typically iterative task of model parameterization. Due to the analytic derivation of the local linear models, the relation to the original parameters of the non-linear model is retained. Furthermore, the local linear models enable a straight-forward parameter significance and identifiability analysis with respect to experimental data. The proposed method is demonstrated using experimental data from a 30 kW commercial polymer electrolyte membrane fuel cell stack. 相似文献
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Plasmaprimer — functional coatings for adhesion improvement When replacing solvent based paint or adhesion promoter partly new production processes are necessary. Plasma enhanced chemical vapor deposition offers to change the surface characteristics of parts according to the necessities of the following application. At the same time improvements in adhesion, in handling and environmental compatibility can be achieved. In this article an according production method is described and perspectives of new developments are shown. 相似文献
87.
Jan Penckwitt Robert van Geldern Burkard Hagspiel Birgit Packebusch Alexander Mahr Klaus Burkhardt Johannes A. C. Barth 《Grundwasser》2016,21(3):217-225
Infiltration of groundwater into sewer systems increases the costs for wastewater treatment plant operators. This study explores groundwater infiltration to urban sewer systems in the city of Nuremberg (Germany). Measurements of stable isotopes at the water works, storage tanks, groundwater, and the sewage network were carried out to define input end members for mass balance calculations. Only minor differences in oxygen stable isotopes (δ18OH2O) were found between most sewer and drinking water samples which ranged around (??9.5?±?0.1) ‰. One exception was water from a water works at Genderkingen that is situated about 80 km south of Nuremberg. Here, drinking water from bank filtrate of the Lech River had more negative δ18OH2O values of ??11.4?‰. This difference of 1.5?‰ revealed maximum possible groundwater contributions of 41?% by mass balance calculations. To obtain more accurate results, we suggest testing the use of deuterium-enriched water (D2O) added to the sewer system. 相似文献
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Felix Schubert Steffen Wirth Friederike Zimmermann Johannes Heitmann Thomas Mikolajick 《Science and Technology of Advanced Materials》2016,17(1):239-243
Growth conditions have a tremendous impact on the unintentional background impurity concentration in gallium nitride (GaN) synthesized by molecular beam epitaxy and its resulting chemical and physical properties. In particular for oxygen identified as the dominant background impurity we demonstrate that under optimized growth stoichiometry the growth temperature is the key parameter to control its incorporation and that an increase by 55?°C leads to an oxygen reduction by one order of magnitude. Quantitatively this reduction and the resulting optical and electrical properties are analyzed by secondary ion mass spectroscopy, photoluminescence, capacitance versus voltage measurements, low temperature magneto-transport and parasitic current paths in lateral transistor test structures based on two-dimensional electron gases. At a growth temperature of 665?°C the residual charge carrier concentration is decreased to below 1015 cm?3, resulting in insulating behavior and thus making the material suitable for beyond state-of-the-art device applications. 相似文献
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