Optimizing rod window width in positron emission tomography

A technique determines the optimal window width for orbiting rod transmission studies in positron emission tomography (PET). Windowing reduces noise in orbiting rod transmission studies. Lines-of-response (LOR) which intersect the rods generate primarily true coincidence events. LOR which pass far from the rods generate random and scatter events. Since the angular position of the orbiting rods is known in real-time, LOR which produce mostly noise are gated off. When optimally determined, the rod window width maximizes the noise equivalent counts (NEC) collected in the transmission study. Transaxial rod projection profiles of trues, randoms, and scatter produce NEC versus window width plots. For the ECAT EXACT line of PET systems and a 20-cm water cylinder, optimal is five LOR wide.     

Symbolic Intersect Detection: A Method for Improving Spatial Intersect Joins

Due to the increasing popularity of spatial databases, researchers have focused their efforts on improving the query processing performance of the most expensive spatial database operation: the spatial join. While most previous work focused on optimizing the filter step, it has been discovered recently that, for typical GIS data sets, the refinement step of spatial join processing actually requires a longer processing time than the filter step. Furthermore, two-thirds of the time in processing the refinement step is devoted to the computation of polygon intersections. To address this issue, we therefore introduce a novel approach to spatial join optimization that drastically reduces the time of the refinement step. We propose a new approach called Symbolic Intersect Detection (SID) for early detection of true hits. Our SID optimization eliminates most of the expensive polygon intersect computations required by a spatial join by exploiting the symbolic topological relationships between the two candidate polygons and their overlapping minimum bounding rectangle. One important feature of our SID optimization is that it is complementary to the state-of-the-art methods in spatial join processing and therefore can be utilized by these techniques to further optimize their performance. In this paper, we also develop an analytical cost model that characterizes SIDs effectiveness under various conditions. Based on real map data, we furthermore conduct an experimental evaluation comparing the performance of the spatial joins with SID against the state-of-the-art approach. Our experimental results show that SID can effectively identify more than 80% of the true hits with negligible overhead. Consequently, with SID, the time needed for resolving polygon intersect in the refinement step is improved by over 50% over known techniques, as predicted by our analytical model.     

Desflurane-mediated sympathetic activation occurs in humans despite preventing hypotension and baroreceptor unloading

BACKGROUND: Increasing concentrations of desflurane result in progressive decreases in blood pressure (BP) and, unlike other currently marketed, potent volatile anesthetics, heightened sympathetic nervous system activity. This study aimed to determine whether baroreflex mechanisms are involved in desflurane-mediated sympathetic excitation. METHODS: Healthy volunteers were anesthetized with desflurane (n = 8) or isoflurane (n = 9). Heart rate (HR; measured by electrocardiograph), blood pressure (BP; measured by arterial catheter), and efferent sympathetic nerve activity (SNA; obtained from percutaneous recordings from the peroneal nerve) were monitored. Baroreflex sensitivity was evaluated at baseline while volunteers were conscious and during 0.5, 1, and 1.5 minimum alveolar concentration (MAC) anesthesia via bolus injections of nitroprusside (100 microg) and phenylephrine (150 microg) to decrease and increase BP. To prevent the BP decline with increasing depths of anesthesia, phenylephrine was infused to maintain mean BP at the 0.5 MAC level. RESULTS: The HR, BP, and SNA were similar between the groups at the conscious baseline measurement. Efferent SNA did not change during higher MAC of isoflurane, but it increased progressively as desflurane concentrations were increased beyond 0.5 MAC, despite maintaining BP at the 0.5 MAC value with phenylephrine infusions (P < 0.05). Cardiac baroslopes (based on changes in HR) were progressively and similarly decreased with increasing concentrations of isoflurane and desflurane (P < 0.05). Sympathetic baroslopes (based on SNA) decreased with increasing isoflurane concentrations but were maintained with increasing concentrations of desflurane; the response was significantly different between groups. CONCLUSIONS: The increase in basal levels of SNA with increasing concentrations of desflurane persisted despite "fixing" BP and thus is probably not due to hypotension and unloading of the baroreceptors. Further, the preservation of reflex increases in SNA to nitroprusside during desflurane indicates that desflurane preserves one component of the baroreflex in humans when BP is "fixed."     

Rupture of a hepatic artery aneurysm and renal infarction: 2 complications of fibromuscular dysplasia that mimic vasculitis

Fibromuscular dysplasia (FMD) is one of the most important mimics of vasculitis. FMD is more prevalent in women and may cause infarcts of organ systems including the brain, intestines, and extremities. These acute clinical presentations often raise the suspicion of vasculitis and therefore rheumatologists will be asked to evaluate these patients. One of the frequent manifestations of FMD is renal artery involvement. Angiographic evaluation often shows a "string of beads" appearance of the renal arteries but sometimes only tapering of the vascular lumen or cutoffs may be seen. In contrast, hepatic artery involvement with FMD occurs much less frequently and may initially present with life threatening intraabdominal bleeding. Celiac angiograms of these patients often show aneurysms, a presentation similar to vasculitis. Only a high level of suspicion for FMD and careful evaluation of clinical facts will lead to correct diagnosis. This will prevent the wrong diagnosis of vasculitis and subsequent treatment with potentially toxic medications. We present 2 cases of FMD involving the renal and hepatic arteries that illustrate this diagnostic challenge.     

Nutrition support for patients after cardiopulmonary bypass: required modifications of the TPN solution

Background electrolyte (BGE) systems with two coions are frequently used in capillary zone electrophoresis (CZE), especially in cases where indirect optical detection is employed. This study investigates the behavior of analytes, which possess mobilities intermediate to those of the BGE coions used. Besides the expected behavior, where the analytes provide either tailing or fronting zones, unusual behavior with extraordinary zone broadening is also observed in some cases. The explanation for this effect is that binary BGE systems involve, as a physico-chemical rule, a region where the analytes are forced by one coion to give tailing zones and simultaneously by the other coion to give fronting zones. The result of this "schizophrenic" situation is extraordinary zone broadening and deterioration of the detection record. A series of experiments is presented showing in a telling way the electromigration behavior of the discussed type of zones as well as the ways to remedy the deterioration of the peak shape by a mere slight changing of the quantitative composition of the BGE used.     

Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity

Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity. However, the "default" T helper response at mucosal surfaces demonstrates Th2 polarity, which is reflected in the cytokine profiles of activated T cells from mucosal lymph nodes. This study on rat respiratory tract DCs (RTDCs) provides an explanation for this paradox. We demonstrate that freshly isolated RTDCs are functionally immature as defined in vitro, being surface major histocompatibility complex (MHC) II lo, endocytosishi, and mixed lymphocyte reactionlo, and these cells produce mRNA encoding interleukin (IL)-10. After ovalbumin (OVA)-pulsing and adoptive transfer, freshly isolated RTDCs preferentially stimulated Th2-dependent OVA-specific immunoglobulin (Ig)G1 responses, and antigen-stimulated splenocytes from recipient animals produced IL-4 in vitro. However, preculture with granulocyte/macrophage colony stimulating factor increased their in vivo IgG priming capacity by 2-3 logs, inducing production of both Th1- and Th2-dependent IgG subclasses and high levels of IFN-gamma by antigen-stimulated splenocytes. Associated phenotypic changes included upregulation of surface MHC II and B7 expression and IL-12 p35 mRNA, and downregulation of endocytosis, MHC II processing- associated genes, and IL-10 mRNA expression. Full expression of IL-12 p40 required additional signals, such as tumor necrosis factor alpha or CD40 ligand. These results suggest that the observed Th2 polarity of the resting mucosal immune system may be an inherent property of the resident DC population, and furthermore that mobilization of Th1 immunity relies absolutely on the provision of appropriate microenvironmental costimuli.     

Thermal stability of the αZn–Mg2Zn11 and αZn–βAl eutectics obtained by Bridgman growth

The thermal stability of rod-like Zn–Mg2Zn11 and lamellar Zn–Al eutectics obtained by Bridgman growth of Zn–3.1 wt% Mg and Zn–5 wt% Al has been studied for soaking times up to 10 h at 300 and 350°C, respectively. Two-dimensional coarsening resulted for Zn–Mg2Zn11 grown at 0.5 and 1 mm s-1 while fault migration was operative for lamellar Zn–Al grown at 0.1 and 1 mm s-1. Hardness decreased with increased soaking time according to a Hall–Petch relationship with mean interphase spacing and the values H0 and kY accord well with the values obtained from the Hall–Petch relationship for HV of as-solidified Zn–Mg2Zn11 and Zn–Al with eutectic interphase spacing, respectively. © 1998 Chapman & Hall     

Analysis of dynamic magnetic resonance images

Dynamic magnetic resonance (MR) imaging with contrast agents is a very promising technique for studying tissue perfusion in vivo. A temporal series of magnetic resonance images of the same slice are acquired following the injection of a contrast agent into the blood stream. The image intensity depends on the local concentration of the contrast agent, so that tissue perfusion can be studied by the image series. A new method of analyzing such series is described here. Nonparametric linear regression is used for modeling the image intensity along the series on a pixel by pixel basis. After modeling, some relevant quantities describing the time series are obtained and displayed as images. Due to its flexibility, this approach is preferred to parametric modeling when pathology is present since this can induce a wide spread of patterns for the pixel image intensity along time. Results of the application of the method to series of dynamic magnetic resonance images from ischaemic rat brains after the injection of the susceptibility agent Sprodiamide Inj. (Dy-DTPA-BMA) are shown and compared to results from a related known method.     

Analysis of error-correction constraints in an optical disk

The compact disk read-only memory (CD-ROM) is a mature storage medium with complex error control. It comprises four levels of Reed Solomon codes allied to a sequence of sophisticated interleaving strategies and 8:14 modulation coding. New storage media are being developed and introduced that place still further demands on signal processing for error correction. It is therefore appropriate to explore thoroughly the limit of existing strategies to assess future requirements. We describe a simulation of all stages of the CD-ROM coding, modulation, and decoding. The results of decoding the burst error of a prescribed number of modulation bits are discussed in detail. Measures of residual uncorrected error within a sector are displayed by C1, C2, P, and Q error counts and by the status of the final cyclic redundancy check (CRC). Where each data sector is encoded separately, it is shown that error-correction performance against burst errors depends critically on the position of the burst within a sector. The C1 error measures the burst length, whereas C2 errors reflect the burst position. The performance of Reed Solomon product codes is shown by the P and Q statistics. It is shown that synchronization loss is critical near the limits of error correction. An example is given of miscorrection that is identified by the CRC check.