Synthesis of symmetric and asymmetric singly terminated elliptic ladder filters for multiplexing applications

An extension of the Cauer ladder development for synthesizing singly terminated filters with symmetric and asymmetric responses is presented. Basically, a driving‐point immittance including reactive constant elements is carried out in such a way that provides the transmission zeros. The reactive constant elements are introduced into the synthesis for two reasons. The first is to consider the possibility of the asymmetric position of transmission zeros in the real frequency axis. The second one is to obtain canonical forms, i.e. networks with the minimum number of elements in the case of symmetrical responses. To validate the proposed method, a filter with asymmetrical response has been synthesized, comparing different topologies for its use in multiplexers. This fact is illustrated with a Ku‐band elliptic response diplexer designed in H‐plane rectangular waveguide. © 2009 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2009.     

A Genre-Aware Approach to Focused Crawling

Focused crawlers have as their main goal to crawl Web pages that are relevant to a specific topic or user interest, playing an important role for a great variety of applications. In general, they work by trying to find and crawl all kinds of pages deemed as related to an implicitly declared topic. However, users are often not simply interested in any document about a topic, but instead they may want only documents of a given type or genre on that topic to be retrieved. In this article, we describe an approach to focused crawling that exploits not only content-related information but also genre information present in Web pages to guide the crawling process. This approach has been designed to address situations in which the specific topic of interest can be expressed by specifying two sets of terms, the first describing genre aspects of the desired pages and the second related to the subject or content of these pages, thus requiring no training or any kind of preprocessing. The effectiveness, efficiency and scalability of the proposed approach are demonstrated by a set of experiments involving the crawling of pages related to syllabi of computer science courses, job offers in the computer science field and sale offers of computer equipments. These experiments show that focused crawlers constructed according to our genre-aware approach achieve levels of F1 superior to 88%, requiring the analysis of no more than 65% of the visited pages in order to find 90% of the relevant pages. In addition, we experimentally analyze the impact of term selection on our approach and evaluate a proposed strategy for semi-automatic generation of such terms. This analysis shows that a small set of terms selected by an expert or a set of terms specified by a typical user familiar with the topic is usually enough to produce good results and that such a semi-automatic strategy is very effective in supporting the task of selecting the sets of terms required to guide a crawling process.     

Adaptation and application of multi-objective evolutionary algorithms for rule reduction and parameter tuning of fuzzy rule-based systems

Recently, multi-objective evolutionary algorithms have been applied to improve the difficult tradeoff between interpretability and accuracy of fuzzy rule-based systems. It is known that both requirements are usually contradictory, however, these kinds of algorithms can obtain a set of solutions with different trade-offs. This contribution analyzes different application alternatives in order to attain the desired accuracy/interpr-etability balance by maintaining the improved accuracy that a tuning of membership functions could give but trying to obtain more compact models. In this way, we propose the use of multi-objective evolutionary algorithms as a tool to get almost one improved solution with respect to a classic single objective approach (a solution that could dominate the one obtained by such algorithm in terms of the system error and number of rules). To do that, this work presents and analyzes the application of six different multi-objective evolutionary algorithms to obtain simpler and still accurate linguistic fuzzy models by performing rule selection and a tuning of the membership functions. The results on two different scenarios show that the use of expert knowledge in the algorithm design process significantly improves the search ability of these algorithms and that they are able to improve both objectives together, obtaining more accurate and at the same time simpler models with respect to the single objective based approach.

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The Green language type system

A programming language that considers basic values and classes as objects brings more opportunities of code reuse and it is easier to use than a language that does not support this feature. However, popular statically typed object-oriented languages do not consider classes as first-class objects because this concept is difficult to integrate with static type checking. They also do not consider basic values as objects for sake of efficiency. This article presents the Green language type system which supports classes as classless objects and offers a mechanism to treat basic values as objects. The result is a reasonably simple type system which is statically typed and easy to implement. It simplifies several other language mechanisms and prevents any infinite regression of metaclasses.     

Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum

In several autoimmune disorders, including rheumatoid arthritis (RA), autoantibodies are thought to be the driving force of pathogenicity. Glycosylation of the Fc-part of human Igs is known to modulate biological activity. Hitherto, glycosylation of human IgG-Fc has been analyzed predominantly at the level of total serum IgG, revealing reduced galactosylation in RA. Given the pathogenic relevance of autoantibodies in RA, we wished, in the present study, to address the question whether distinct Fc-glycosylation features are observable at the level of antigen-specific IgG subpopulations. For this purpose, we have developed a method for the microscale purification and Fc-glycosylation analysis of anti-citrullinated peptide antibodies (ACPA). ACPA represent a group of autoantibodies that occur with unique specificity in RA patients. Their presence is associated with increased inflammatory disease activity and rapid joint destruction. Results indicate that ACPA of the IgG1 subclass vary considerably from total serum IgG1 with respect to Fc-galactosylation, with galactosylation being higher on ACPA than on serum IgG1 for some patients, while other patients show higher galactosylation on serum IgG1 than on ACPA. Using this method, studies can be performed on the biological and clinical relevance of ACPA glycosylation within RA patient cohorts.     

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

Metal-based anticancer agents are frequently used in the treatment of a wide variety of cancer types. The monitoring of these anticancer agents in biological samples is important to understand their pharmacokinetics, pharmacodynamics, and metabolism. In addition, determination of metals originating from anticancer agents is relevant to assess occupational exposure of health care personnel working with these drugs. The high sensitivity of inductively coupled plasma mass spectrometry (ICP-MS) has resulted in an increased popularity of this technique for the analysis of metal-based anticancer drugs. In addition to the quantitative analysis of the metal of interest in a sample, ICP-MS can be used as an ultrasensitive metal selective detector in combination with speciation techniques such as liquid chromatography. In the current review we provide a systematic survey of publications describing the analysis of platinum- and ruthenium-containing anticancer agents using ICP-MS, focused on the determination of total metal concentrations and on the speciation of metal compounds in biological fluids, DNA- and protein-adducts, and environmental samples. We conclude that ICP-MS is a powerful tool for the quantitative analysis of metal-based anticancer agents from multiple sample sources.     

On the interpretation of the forbidden spots observed in the electron diffraction patterns of flat Au triangular nanoparticles

In many cases nanostructures present forbidden spots in their electron diffraction patterns when they are observed by transmission electron microscopy (TEM). To interpret their TEM and high resolution transmission electron microscopy (HRTEM) images properly, an understanding of the origin of these spots is necessary. In this work we comment on the origin of the forbidden spots observed in the [111] and [112] electron diffraction patterns of flat gold triangular nanoparticles. The forbidden spots were successfully indexed as corresponding to the first laue Zone (FOLZ) and the HRTEM images presented a contrast produced by the interference of the zero-order Laue zone (ZOLZ) and FOLZ spots. We discuss the use of the forbidden spots in the study of the structure of nanoparticles and show that they are related to the shape and incompleteness of layers in the very thin particles.     

Post-embryonic development of the antennal sensilla in Melipona quadrifasciata anthidioides (Hymenoptera: Meliponini)

The sensilla are sensory organs formed by cuticular and cellular structures specialized in reception of chemical and physical stimuli from the environment and transmission to the insect's central nervous system. In function of the great concentration of sensilla, the antennae are the main organs for interaction between bees and with the environment. This work studied the presence of antennal sensilla in the different phases of pupal development of the stingless bee Melipona quadrifasciata anthidioides by means of scanning electron microscopy and light microscopy. The results showed that antennal sensilla begin their development in the transition of the prepupae to the white-eyed pupae and finish it in the pigmented-body pupae phase. The antennal sensilla were exposed to the environment in the black-eyed pupae when the old cuticle is completely digested, suggesting that only in the final pupal phases can these bees perceive the environmental stimuli.     

Intervention practices in musculoskeletal disorder prevention: a critical literature review

Musculoskeletal disorders (MSDs) affect much of the workforce and remain a major form of occupational ill health. With a view to improving the efficacy of interventions, this review examined preventative actions relating to these disorders. A detailed analysis grid was used to classify the information contained in the 47 reviewed articles whose common aspect was to report actions carried out in the workplace that led to the implementation of changes to prevent MSDs. The analysis identified and characterized three major categories of intervention processes in MSD prevention: the complete type (n=17), the shortened type (n=16), and the turnkey type (n=14). These three groups of intervention processes were differentiated by their approaches and their contexts of application. The result was important differences in the changes implemented. Because of the variability in intervention processes and possible impacts on MSD prevention, a proposal to "delimit" these processes so as to improve their effectiveness is presented.