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11.
Farzaneh Fayazpour Bart Lucas Roosmarijn E. Vandenbroucke Stefaan Derveaux Jan Tavernier Sam Lievens Joseph Demeester Stefaan C. De Smedt 《Advanced functional materials》2008,18(18):2716-2723
To obtain more biologically relevant data there is a growing interest in the use of living cells for assaying the biological activity of unknown chemical compounds. Density ‘multiplex’ cell‐based assays, where different cell types are mixed in one well and simultaneously investigated upon exposure to a certain compound are beginning to emerge. To be able to identify the cells they should be attached to microscopic carriers that are encoded. This paper investigates how digitally encoded microparticles can be loaded with cells while keeping the digital code in the microcarriers readable. It turns out that coating the surface of the encoded microcarriers with polyelectrolytes using the layer‐by‐layer (LbL) approach provides the microcarriers with a ‘highly functional’ surface. The polyelectrolyte layer allows the growth of the cells, allows the orientation of the cell loaded microcarriers in a magnetic field, and does not hamper the reading of the code. It has further been shown that the cells growing on the polyelectrolyte layer can become transduced by adenoviral particles hosted by the polyelectrolyte layer. It is concluded that the digitally encoded microparticles are promising materials for use in biomedical and pharmaceutical in‐vitro research where cells are used as tools. 相似文献
12.
Notes that, with this issue, the journal Psychoanalytic Psychology begins its 20th year of publication. The journal's editor discusses new features for 2003, and the unique contributions of the journal as the second largest psychoanalytic journal published in the US. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
13.
Termites live in a material world: exploration of their ability to differentiate between food sources. 下载免费PDF全文
Ra Inta Joseph C S Lai Eugene W Fu Theodore A Evans 《Journal of the Royal Society Interface》2007,4(15):735-744
Drywood termites are able to assess wood size using vibratory signals, although the exact mechanism behind this assessment ability is not known. Important vibratory characteristics such as the modal frequencies of a wooden block depend on its geometry and boundary conditions; however, they are also dependent on the material characteristics of the block, such as mass, density and internal damping. We report here on choice experiments that tested the ability of the drywood termite Cryptotermes secundus to assess wooden block size using a solid wooden block paired with a composite block, the latter made of either wood and aluminium or wood and rubber. Each composite block was constructed to match mass or low-frequency vibratory modes (i.e. fundamental frequency) of the solid wooden block. The termites always chose the blocks with more wood; they moved to the solid wooden blocks usually within a day and then tunnelled further into the solid wooden block by the end of the experiment. Termites offered composite blocks of wood and rubber matched for mass were the slowest to show a preference for the solid wooden block and this preference was the least definitive of any treatment, which indicated that mass and/or damping may play a role in food assessment. This result clearly shows that the termites were not fooled by composite blocks matched for mass or frequency, which implies that they probably employ more than a single simple measure in their food assessment strategy. This implies a degree of sophistication in their ability to assess their environment hitherto unknown. The potential importance of alternative features in the vibrational signals is discussed. 相似文献
14.
The current study replicated, in a sample of 2,300 outpatients seeking psychiatric treatment, a previous study (R. F. Krueger & M. S. Finger, 2001) that implemented an item response theory approach for modeling the comorbidity of common mood and anxiety disorders as indicators along the continuum of a shared latent factor (internalizing). The 5 disorders examined were major depressive disorder, social phobia, panic disorder/agoraphobia, specific phobia, and generalized anxiety disorder. The findings were consistent with the prior research. First, a confirmatory factor analysis yielded sufficient evidence for a nonspecific factor underlying the 5 diagnostic indicators. Second, a 2-parameter logistic item response model showed that the diagnoses were represented in the upper half of the internalizing continuum, and each was a strongly discriminating indicator of the factor. Third, the internalizing factor was significantly associated with 3 indexes of social burden: poorer social functioning, time missed from work, and lifetime hospitalizations. Rather than the categorical system of presumably discrete disorders presented in DSM-IV, these 5 mood and anxiety disorders may be alternatively viewed as higher end indicators of a common factor associated with social cost. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
15.
Comments on the original article "A New Big Five: Fundamental Principles for an Integrative Science of Personality," by Dan P. McAdams and Jennifer L. Pals (see record 2006-03947-002). McAdams and Pals (April 2006) presented a new model to integrate the field of personality psychology. Cultural and evolutionary factors interact with an individual's basic traits, characteristic adaptations, and life narratives, which in turn are linked to roles, demands, and behaviors. The current authors welcome McAdams and Pals's (2006) model for providing a way to integrate much of the previously disparate empirical findings in personality psychology. However, the current authors also think that McAdams and Pals (2006) overstated the inclusiveness of the model, and more generally, the current authors dispute their assertion that the grand theories of personality can be integrated within a single model. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
16.
NE Joseph C Fiocchi AD Levine 《Canadian Metallurgical Quarterly》1997,122(4):809-14; discussion 814-6
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases, and their pathogenesis is attributed, in part, to alterations of the mucosal immune system. This study was designed to define the possible contribution of epithelial cells to the activation of lamina propria T lymphocytes (LPTs) in CD and UC. METHODS: LPTs isolated from CD, UC, and control surgical specimens were cocultured with freshly isolated allogeneic or autologous epithelial cells or epithelial cell lines. Resulting T-cell proliferation was evaluated by tritiated thymidine incorporation on day 5. RESULTS: When intestinal epithelial cells were used to stimulate mucosal T-cell proliferation, CD and UC LPTs were less responsive than control LPTs (p < 0.05 and p < 0.03, respectively). This difference between inflamed and control T cells was consistently observed by using a variety of different intestinal epithelial cell types. CONCLUSIONS: CD and UC mucosal T cells are hyporesponsive to activation by intestinal epithelial cells when compared with control LPTs. Elucidating the mechanism underlying the differential activation of CD and UC LPTs may help to better understand the immunopathogenesis of these conditions. 相似文献
17.
AJ Joseph 《Canadian Metallurgical Quarterly》1997,17(4):685-699
Conceptually, the Chest Pain Center model is nothing more than a system of delivering health care. It is a model that all hospitals can embrace as a framework for organizational decision making in meeting the heart-care needs of their communities. It also provides a framework for clinical decision making. By adopting some or all of the common features of the model, hospitals develop a common language, similar to what took place when CCUs first opened in the 1960s. Application of evidence-based clinical practice is promoted. Approaches that account for both clinical outcomes and financial outcomes will be further refined. One result will be simultaneous improvement in clinical outcomes and a decrease in costs, but the most important aspect of the Chest Pain Center model is that it puts the patient first. 相似文献
18.
Grens C.M. Cressler J.D. Andrews J.M. Qingqing Liang Joseph A.J. 《Electron Devices, IEEE Transactions on》2007,54(7):1605-1616
This paper presents a comprehensive picture of operating-voltage constraints in SiGe heterojunction bipolar transistors, addressing breakdown-related issues as they relate to technology generation, bias configuration, and operating-current density. New definitions for breakdown voltage, adopted from standard measurements, are presented. Practical design implications and physical origins of breakdown are explored using calibrated 2-D simulations and quasi-3-D compact models. Device-level analysis of ac instabilities and power performance, which is relevant to mixed-signal circuit design, is presented, and implications of the relaxed voltage constraints for common-base operation are explored. 相似文献
19.
20.
Responds to the comments by J. J. Kramer (see record 1990-58925-001) on the current author's original article (see record 1986-19878-001), in which Matarazzo contends that computerized clinical psychological test interpretations offer considerable potential for improving the work of health service providers. However, cost additions associated with this technology have increased the probabilities that legislative, judicial, and administrative restrictions and sanctions will be imposed. Here, Matarazzo notes that he finds nothing in Kramer's comments that is inconsistent with the opinions that Matarazzo himself offered. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献