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11.
Detecting Deception in Children: Event Familiarity Affects Criterion-Based Content Analysis Ratings.
12.
Research and development involving the preparation and application of fibrous resins is an area of growing interest in the field of ion exchange. Fibrous resins have significant advantages over conventional resins of which fast kinetics is the most important. This article reviews ion-exchange fibers, focusing on metallurgical applications. Work at Mintek on the development offibers for the recovery of gold is described in some detail. 相似文献
13.
This paper analyses inter-organizational networks that link together firms operating in the food processing and distribution industry in the UK. In doing so, the paper draws on insights recently developed by Mark Casson that treat inter-firm networks as an institutional response to the changing costs and opportunities of information management. Detailed analysis of product innovation and supply-chain management issues within the industry, exemplified by the growth of chilled ready-meals, leads to the identification of two distinct but complementary inter-firm networks: a network of control and a network of innovation. In each case, the study finds that the critical information is derived from the retailers' interface with consumers and thus that these information-based networks are effectively controlled by the leading supermarket chains. The study's conclusions are considered in relation to the recent findings of the UK Competition Commission following its investigation into grocery retailing in Britain. 相似文献
14.
Longabaugh Richard; Wirtz Philip W.; Beattie Martha C.; Noel Nora; Stout Robert 《Canadian Metallurgical Quarterly》1995,63(2):296
Patients were randomly assigned to 1 of 3 treatments: brief broad-spectrum (BBS), extended relationship enhancement (ERE), or extended cognitive–behavioral (ECB). A hierarchical latent growth model was used to analyze the data of 188 patients (82%) followed for 18 months. ERE treatment was significantly more effective in increasing abstinence of patients entering treatment with a network unsupportive of abstinence or with a low level of investment in their network, whereas BBS treatment was more effective for patients with either (a) both a social network unsupportive of abstinence and a low level of network investment or (b) high investment in a network supportive of abstinence. ECB outcomes were neither as good as those matched nor as bad as those mismatched to the different exposures of relationship enhancement. This suggests that dose of relationship enhancement should be determined after assessing patient relationships. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
15.
Rasheed A. Bailey Derek L. Beahm I. Martha Skerrett 《International journal of molecular sciences》2021,22(5)
Glycine is an amino acid with unique properties because its side chain is composed of a single hydrogen atom. It confers conformational flexibility to proteins and conserved glycines are often indicative of protein domains involving tight turns or bends. All six beta-type connexins expressed in human epidermis (Cx26, Cx30, Cx30.3, Cx31, Cx31.1 and Cx32) contain a glycine at position 12 (G12). G12 is located about halfway through the cytoplasmic amino terminus and substitutions alter connexin function in a variety of ways, in some cases altering protein interactions and leading to cell death. There is also evidence that alteration of G12 changes the structure of the amino terminus in connexin- and amino acid- specific ways. This review integrates structural, functional and physiological information about the role of G12 in connexins, focusing on beta-connexins expressed in human epidermis. The importance of G12 substitutions in these beta-connexins is revealed in two hereditary skin disorders, keratitis ichthyosis and erythrokeratodermia variabilis, both of which result from missense mutations affecting G12. 相似文献
16.
Rodrigo F. Ortiz-Meoz Liping Wang Rosalie Matico Anna Rutkowska-Klute Martha De la Rosa Sabrina Bedard Robert Midgett Katrin Strohmer Douglas Thomson Cunyu Zhang Makda Mebrahtu Jeffrey Guss Rachel Totoritis Thomas Consler Nino Campobasso David Taylor Tia Lewis Kurt Weaver Marcel Muelbaier John Seal Richard Dunham Wieslaw Kazmierski David Favre Giovanna Bergamini Lisa Shewchuk Alan Rendina Guofeng Zhang 《Chembiochem : a European journal of chemical biology》2021,22(3):516-522
Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the rate-limiting step in the kynurenine pathway of tryptophan (TRP) metabolism. As it is an inflammation-induced immunoregulatory enzyme, pharmacological inhibition of IDO1 activity is currently being pursued as a potential therapeutic tool for the treatment of cancer and other disease states. As such, a detailed understanding of the mechanism of action of IDO1 inhibitors with various mechanisms of inhibition is of great interest. Comparison of an apo-form-binding IDO1 inhibitor (GSK5628) to the heme-coordinating compound, epacadostat (Incyte), allows us to explore the details of the apo-binding inhibition of IDO1. Herein, we demonstrate that GSK5628 inhibits IDO1 by competing with heme for binding to a heme-free conformation of the enzyme (apo-IDO1), whereas epacadostat coordinates its binding with the iron atom of the IDO1 heme cofactor. Comparison of these two compounds in cellular systems reveals a long-lasting inhibitory effect of GSK5628, previously undescribed for other known IDO1 inhibitors. Detailed characterization of this apo-binding mechanism for IDO1 inhibition might help design superior inhibitors or could confer a unique competitive advantage over other IDO1 inhibitors vis-à-vis specificity and pharmacokinetic parameters. 相似文献
17.
Joseph C. Goffreda Martha A. Mutschler Dirk A. Avé Ward M. Tingey John C. Steffens 《Journal of chemical ecology》1989,15(7):2135-2147
Settling of the potato aphid,Macrosiphum euphorbiae, on feeding membranes was deterred by methanolic leaf rinses ofLycopersicon pennellii, or of its F1 with tomato,L. esculentum. The active compounds in theL. pennellii rinsates were identified as 2,3,4-tri-O-acylglucoses bearing short to medium chain length fatty acids. These compounds are localized in the glandular exudate of the type IV trichomes and may accumulate to levels in excess of 400 g/cm2. In choice assays, purified glucose esters fromL. pennellii reduced aphid settling at concentrations as low as 25 g/cm2; at concentrations of 150 g/cm2 or more, all aphids avoided treated areas. Glucose esters were also active in deterring aphid settling in no-choice assays. At 100 g/ cm2, these esters resulted in increased levels of mortality after 48 hr. 相似文献
18.
Maria Gust Grace Goo Jeff Wolfenstine Martha L. Mecartney 《Journal of the American Ceramic Society》1993,76(7):1681-1690
Amorphous silicate grain boundary phases of varying chemistry and amounts were added to 3Y-TZP in order to determine their influence on the superplastic behavior between 1200° and 1300°C and on the room-temperature mechanical properties. Strain rate enhancement at high temperatures was observed in 3Y-TZP containing a glassy grain boundary phase, even with as little as 0.1 wt% glass. Strain rate enhancement was greatest in 3Y-TZP with 5 wt% glass, but the room-temperature hardness, elastic modulus, and fracture toughness were degraded. The addition of glassy grain boundary phases did not significantly affect the stress exponent of 3Y-TZP, but did lower the activation energy for superplastic flow. Strain rate enhancement was highest in samples containing the grain boundary phase with the highest solubility for Y2 O3 and ZrO2 , but the strain rate did not scale inversely with the viscosity of the silicate phases. Grain boundary sliding accommodated by diffusional creep controlled by an interface reaction is proposed as the mechanism for superplastic deformation in 3Y-TZP with and without glassy grain boundary phases. 相似文献
19.
Daniela M. Bonafede Lawrence J. Macala Martha Costantine-Paton Robert K. Yu 《Lipids》1989,24(8):680-684
Bovine buttermilk contains a unique ganglioside, 9-O-acetyl-GD3. In order to isolate large quantities of this ganglioside, a simplified isolation scheme which consists of several ion-exchange
and silica gel column chromatographic procedures was devised. The isolated 9-O-acetyl-GD3 was characterized on the basis of its thin-layer chromatographic behavior, its immunoreactivity with a specific monoclonal
antibody, JONES, and by conversion to authentic GD3 by mild base treatment. 相似文献
20.
A. C. O. Miranda L. F. Martha P. A. Wawrzynek A. R. Ingraffea 《Engineering with Computers》2009,25(2):207-219
This work describes an automatic algorithm for unstructured mesh regeneration on arbitrarily shaped three-dimensional surfaces.
The arbitrary surface may be: a triangulated mesh, a set of points, or an analytical surface (such as a collection of NURBS
patches). To be generic, the algorithm works directly in Cartesian coordinates, as opposed to generating the mesh in parametric
space, which might not be available in all the cases. In addition, the algorithm requires the implementation of three generic
functions that abstractly represent the supporting surface. The first, given a point location, returns the desired characteristic
size of a triangular element at this position. The second method, given the current edge in the boundary-contraction algorithm,
locates the ideal apex point that forms a triangle with this edge. And the third method, given a point in space and a projection
direction, returns the closest point on the geometrical supporting surface. This work also describes the implementation of
these three methods to re-mesh an existing triangulated mesh that might present regions of high curvature. In this implementation,
the only information about the surface geometry is a set of triangles. In order to test the efficiency of the proposed algorithm
of surface mesh generation and implementation of the three abstract methods, results of performance and quality of generated
triangular element examples are presented. 相似文献