L'échelle de dramatisation face à la douleur PCS-CF: Adaptation canadienne en langue fran?aise de l'échelle Pain Catastrophizing Scale.

This study examined the psychometric properties of the PCS-CF, a French-Canadian adaptation of the Pain Catastrophizing Scale (Sullivan, Bishop & Pivik, 1995). One hundred and twenty undergraduate students (83 women; 37 men) completed the PCS-CF and measures of anxiety and depression prior to immersing their hand in ice water for 1-minute. A subset of 39 participants (28 females; 11 males) also completed a second pain task involving an ascending series of electrocutaneous stimulations. Participants' verbal and non-verbal pain behaviours during and immediately after the immersion task were recorded and subsequently independently coded. Reliability analyses revealed that the PCS-CF total score and subscale scores have a high degree of internal consistency and test-retest reliabilities that are comparable to the original Pain Catastrophizing Scale. PCS-CF scores were associated with higher levels of self-reported pain during the ice water immersion task and decreased pain tolerance during electrocutaneous stimulation. Individuals with elevated PCS-CF scores also displayed a more diverse repertoire of pain behaviours than their low PCS-CF counterparts. Previous findings that catastrophizing scores are able to discriminate criterion groups of males and females were also replicated. Given the highly correlated factors obtained in analyses of the dimensionality of the PCS-CF, the structure suggested by the authors of the original scale is only partially supported. However, the results taken together suggest that the PCS-CF is both a reliable and valid measure of the pain catastrophizing construct that is psychometrically comparable to the original PCS. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A unified formulation for continuum mechanics applied to fluid–structure interaction in flexible tubes

This paper outlines the development of a new procedure for analysing continuum mechanics problems with a particular focus on fluid–structure interaction in flexible tubes. A review of current methods of fluid–structure coupling highlights common limitations of high computational cost and solution instability. It is proposed that these limitations can be overcome by an alternative approach in which both fluid and solid components are solved within a single discretized continuum domain. A single system of momentum and continuity equations is therefore derived that governs both fluids and solids and which are solved with a single mesh using finite volume discretization schemes. The method is validated first by simulating dynamic oscillation of a clamped elastic beam. It is then applied to study the case of interest—wave propagation in highly flexible tubes—in which a predicted wave speed of 8.58 m/s falls within 2% of an approximate analytical solution. The method shows further good agreement with analytical solutions for tubes of increasing rigidity, covering a range of wave speeds from those found in arteries to that in the undisturbed fluid. Copyright © 2005 John Wiley & Sons, Ltd.     

Cognitive Trauma Therapy for Battered Women With PTSD (CTT-BW).

This article describes a second treatment-outcome study of cognitive trauma therapy for battered women with posttraumatic stress disorder (PTSD; CTT-BW). CTT-BW includes trauma history exploration: PTSD education; stress management; exposure to abuse and abuser reminders; self-monitoring of negative self-talk; cognitive therapy for guilt; and modules on self-advocacy, assertiveness, and how to identify perpetrators. One hundred twenty-five ethnically diverse women were randomly assigned to immediate or delayed CTT-BW. PTSD remitted in 87% of women who completed CTT-BW, with large reductions in depression and guilt and substantial increases in self-esteem. White and ethnic minority women benefited equally from CTT-BW. Similar treatment outcomes were obtained by male and female therapists and by therapists with different levels of education and training. Gains were maintained at 3- and 6-month follow-ups. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mismatches in Social Support and Psychosocial Adjustment to Breast Cancer.

Emotional support is known to provide psychosocial benefits for women with breast cancer, but women can experience a mismatch between support that is wanted and support that is received from their personal supporter. The role of wanted and unwanted support in psychosocial adjustment was examined in 79 women recovering from breast cancer. Four distinct patterns of desired support actions were found using cluster analysis. Patterns of wanted support were not related to better or worse psychosocial adjustment. However, a misalignment of support between the provider and the receiver significantly influenced psychosocial adjustment, and unwanted but received support (support commission) was uniquely associated with poor psychosocial adjustment. Clinical interventions using the support instrument could help match support providers' actions to receivers' preferences. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evaluating the Endophenotype Model of ADHD Neuropsychological Deficit: Results for Parents and Siblings of Children With ADHD Combined and Inattentive Subtypes.

Neurogenetic models predict neuropsychological weaknesses in the relatives of children with attention-deficit/ hyperactivity disorder (ADHD). The authors examined executive and regulatory measures in 386 relatives (307 parents, 79 siblings) of children with ADHD combined type, ADHD inattentive type, and controls. Predicted deficits were seen on trailmaking (relatives of ADHD combined type only), stop-signal reaction times (relatives of girls only), and response variability (mothers only) but not on naming or output speed. Effects generally held, even with relatives' ADHD status controlled. A neuropsychologically impaired subgroup of children with ADHD had relatives with clear neuropsychological weaknesses. The authors conclude that a neurogenetic model of ADHD etiology is supportable only for a subset of executive functions and that neuropsychological heterogeneity warrants more examination in ADHD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Parent and Child Psychological Factors in Pediatric Syncope and Other Somatic Symptoms.

The authors examined associations among parental and child adjustment, child syncope, somatic, and school problems. Participants were children (N = 56) ages 7-18 years with syncope. Measures included syncope severity, parental distress, and children's internalizing symptoms. For children diagnosed negative for neurocardiogenic syncope (NCS), their fathers' and their own psychological symptoms were positively associated with the severity of syncope, whereas their mothers' functioning was negatively associated with the severity of syncope. Also, for the negative NCS group, fathers' psychological functioning was associated with children's nonsyncope somatic complaints but not with their school problems. For the positive NCS group, few significant father-child associations were found, but several significant positive associations were revealed between mothers' psychological symptoms and their children's syncope as well as somatic and school problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A longitudinal analysis of anxiety and depressive symptoms.

The authors modeled depressive and anxiety symptom data from 1,391 participants in a longitudinal study of middle-aged and older Swedish twins (M age?=?60.9 years, SD?=?13.3). Although anxiety and depression were highly correlated, a model with distinct Anxiety and Depression factors fit the data better than models with Positive and Negative Affect factors or a single Mental Health factor. Lack of well-being was associated with anxiety rather than depression. Over two 3-year intervals, anxiety symptoms led to depressive symptoms, but the relationship was not reciprocal. Anxiety symptoms were more stable than depression. These findings provide additional support for the idea that anxiety symptoms may reflect a personality trait such as neuroticism more than do depressive symptoms and suggest that low positive affect may not be as specific to depression among older adults as in younger people. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Culture and group perception: Dispositional and stereotypic inferences about novel and national groups.

In 3 studies, the authors tested the hypothesis that Chinese participants would view social groups as more entitative than would Americans and, as a result, would be more likely to infer personality traits on the basis of group membership--that is, to stereotype. In Study 1, Chinese participants made stronger stereotypic trait inferences than Americans did on the basis of a target's membership in a fictitious group. Studies 2 and 3 showed that Chinese participants perceived diverse groups as more entitative and attributed more internally consistent dispositions to groups and their members. Guided by culturally based lay theories about the entitative nature of groups, Chinese participants may stereotype more readily than do Americans when group membership is available as a source of dispositional inference. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Flash Lamp Annealing of ITO thin films on ultra‐thin glass

Ultra‐fast thermal annealing of thin films with annealing times of few milliseconds are faster und more energy efficient than conventional furnace annealing methods. By using flash lamp annealing, only the surface is heated while the substrate remains cold. This allows the refinement of indium‐tin‐oxide films on rigid and ultra‐thin flexible glass and improves their conductivity and transmittance.     

Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment

Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However, PSMA-TRT cannot be used for curative intent yet, thus additional research on how to improve the therapeutic efficacy is warranted. A potential way of achieving this, is combining TRT with poly ADP-ribosylation inhibitors (PARPi), which has shown promising results for TRT of neuroendocrine tumor cells. Currently, several clinical trials have been initiated for this combination for PCa, however so far, no evidence of synergism is available for PCa. Therefore, we evaluated the combination of PSMA-TRT with three classes of PARPi in preclinical PCa models. In vitro viability and survival assays were performed using PSMA-expressing PCa cell lines PC3-PIP and LNCaP to assess the effect of increasing concentrations of PARPi veliparib, olaparib or talazoparib in combination with PSMA-TRT compared to single PARPi treatment. Next, DNA damage analyses were performed by quantifying the number of DNA breaks by immunofluorescent stainings. Lastly, the potential of the combination treatments was studied in vivo in mice bearing PC3-PIP xenografts. Our results show that combining PSMA-TRT with PARPi did not synergistically affect the in vitro clonogenic survival or cell viability. DNA-damage analysis revealed only a significant increase in DNA breaks when combining PSMA-TRT with veliparib and not in the other combination treatments. Moreover, PSMA-TRT with PARPi treatment did not improve tumor control compared to PSMA-TRT monotherapy. Overall, the data presented do not support the assumption that combining PSMA-TRT with PARPi leads to a synergistic antitumor effect in PCa. These results underline that extensive preclinical research using various PCa models is imperative to validate the applicability of the combination strategy for PCa, as it is for other cancer types.