Development and characterization of pseudolatex based transdermal drug delivery system of diclofenac.

A transdermal drug delivery system of diclofenac was developed for prolonged and controlled release of diclofenac. The designed system essentially based on polymeric pseudolatex dispersion. The formulation variables that could effect the formulation stability vis a vis drug release were studied. To achieve the desired release rate, different combination of hydrophilic and hydrophobic polymer were used for the preparation of pseudolatex system. The designed system exhibited linear relationship between drug release (Q) V/s square root of time (t^0.5). The product having skin permeability rate 0.188 mg/h/cm was selected for the in vitro anti-inflammatory activity and in vivo evaluation. The system could maintained a constant and effective plasma level for 24 hours. The effective drug plasma concentration was monitored periodically. The study revealed that designed pseudolatex transdermal drug delivery system of diclofenac could be used successfully with improved performance and hold promise for further studies.     

Topology design with optimized,self-adaptive materials

Significant performance improvements can be obtained if the topology of an elastic structure is allowed to vary in shape optimization problems. We study the optimal shape design of a two-dimensional elastic continuum for minimum compliance subject to a constraint on the total volume of material. The macroscopic version of this problem is not well-posed if no restrictions are placed on the structure topoiogy; relaxation of the optimization problem via quasiconvexification or homogenization methods is required. The effect of relaxation is to introduce a perforated microstructure that must be optimized simultaneously with the macroscopic distribution of material. A combined analytical-computational approach is proposed to solve the relaxed optimization problem. Both stress and displacement analysis methods are presented. Since rank-2 layered composites are known to achieve optimal energy bounds, we restrict the design space to this class of microstructures whose effective properties can easily be determined in explicit form. We develop a series of reduced problems by sequentially interchanging extremization operators and analytically optimizing the microstructural design fields. This results in optimization problems involving the distribution of an adaptive material that continuously optimizes its microstructure in response to the current state of stress or strain. A further reduced problem, involving only the response field, can be obtained in the stress-based approach, but the requisite interchange of extremization operators is not valid in the case of the displacement-based model. Finite element optimization procedures based on the reduced displacement formulation are developed and numerical solutions are presented. Care must be taken in selecting the discrete function spaces for the design density and displacement response, since the reduced problem is a two-field, mixed variational problem. An improper choice for the solution space leads to instabilities in the optimal design similar to those encountered in mixed formulations of the Stokes problem.     

Stability of finite element models for distributed-parameter optimization and topology design

We address a problem of numerical instability that is often encountered in finite element solutions of distributed-parameter optimization and variable-topology shape design problems. We show that the cause of this problem is numerical rather than physical in nature. We consider a two-field, distributed-parameter optimization problem involving a design field and a response field, and show that the optimization problem corresponds to a mixed variational problem. An improper selection of the discrete function spaces for these two fields leads to grid-scale anomalies in the numerical solutions to optimization problems, similar to those that are sometimes encountered in mixed formulations of the Stokes problem. We present a theoretical framework to explain the cause of these anomalies and present stability conditions for discrete models. The general theoretical framework is specialized to analyze the stability of specific optimization problems, and stability results for various mixed finite element models are presented. We propose patch tests that are useful in identifying unstable elements.     

Viscosity and surface tension of p-xylene-ethylacetate liquid mixtures

Experimental density, viscosity and surface tension data are reported for p-xylene-ethylacetate mixtures at 20°. 30° and 40°C. over the entire composition range. The presence of interactions has been studied in the light of excess properties.     

Interrelationship between the crystallization behavior,injection molding conditions,and morphology of poly(ethylene terephthalate)/poly(methyl methacrylate) alloys

The thermal and isothermal crystallization behavior of PET/PMMA (poly(ethylene terephthalate)/poly(methyl methacrylate)) alloys was investigated. The crystallization of PET is accelerated significantly by alloying with PMMA. As a result, crystalline specimens could be injection molded with the alloy at low mold temperatures of 19°, 55° and 90°C., whereas a mold temperature of about 130°C is normally required for crystallinity to develop in the virgin PET grade. The impact strength of the alloy specimens increased significantly with decreasing mold temperature despite a comparable degree of crystallinity. The increase in impact strength is correlated to the reduction in the crystallite size and broadening of the crystal size distribution with decreasing mold temperature.     

Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis‐gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug‐analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis‐gA ion channels. This system provides a platform for the creation of “smart” biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.     

Dicarbonylruthenium(II) complexes of diphosphine ligands and their catalytic activity

The hexa-coordinated chelate complexes of the type [Ru(CO)₂Cl₂(P-P)](1a,b) [where P-P = 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene(a) and [bis(2-diphenylphosphinophenyl)ether(b)] have been synthesized by reacting the polymeric precursor [Ru(CO)₂Cl₂]_n with the ligands in 1:1 molar ratio. The complexes 1a,b are characterized by elemental analyses, Mass, IR and NMR spectroscopy together with the single crystal X-ray structure determination of 1a. The compound 1a crystallizes in a monoclinic system with space group C2/c showing a slightly distorted octahedral geometry around the Ru centre. The complexes 1a and 1b are thermally stable up to 300 °C and exhibit high catalytic activity in transfer hydrogenation of aldehyde and ketones to corresponding alcohols. The complexes 1a and 1b show much higher catalytic activity for the hydrogenation of aldehyde than ketones. In general, the catalytic efficiency of 1b is higher compared with 1a.     

A comparison of several nanoscale photocatalysts in the degradation of a common pollutant using LEDs and conventional UV light

A comparative study on the photocatalytic activities of four different catalysts, P-25 TiO₂, TiO₂ nanofibers, tin-doped TiO₂ nanofibers under UV light irradiation at 350 nm, and coumarin (C-343) coated TiO₂ nanofibers at 436 nm light emitting diodes (LED) is reported. Catalysts performance has been compared based on their reflectance spectrum and activity. A common water contaminant 4-chlorophenol was used as a substrate to compare the activity of the different catalysts under both direct and dye sensitized conditions. Results indicated that amongst the four different catalysts the activity of P-25 was the highest. However the activity of C-343 coated TiO₂ nanofibers in the LED (436 nm) based reactor was competitive. Identification of reaction intermediates implied that the reaction pathways under UV (band gap) and visible (dye sensitized) irradiation were different. Nonetheless, ring opening took place in all reactions with both maleic and dihydroxymaleic have been identified as intermediates. The study indicates that ordered arrays of TiO₂ irradiated by panels of arrays of low cost high intensity LEDs might be used for the design of reactors. The near monochromaticity, long life, and operation under direct currents are advantages of using LEDs.     

Higher Order Coherences for fatigue crack detection

Higher Order Coherences (normalized Higher Order Spectra) are the tools to identify the relationship between the different harmonic components in a signal. The vibration of a structure having a crack also generates several harmonics of the exciting frequency due to its breathing (closing and opening) behaviour which is a non-linear phenomenon. Presently two types of the HOC — namely, the Bicoherence and the Tricoherence, are used for the fatigue crack detection. This paper presents the observations made on the HOC on the numerically simulated experiment of a cantilever beam with and without cracks. The robustness of the HOC in the crack detection even for the noisy response vibration data has also been brought out.