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41.
The bromodomain and extra terminal (BET) family of bromodomain-containing proteins (BCPs) have been the subject of extensive research over the past decade, resulting in a plethora of high-quality chemical probes for their tandem bromodomains. In turn, these chemical probes have helped reveal the profound biological role of the BET bromodomains and their role in disease, ultimately leading to a number of molecules in active clinical development. However, the BET subfamily represents just 8/61 of the known human bromodomains, and attention has now expanded to the biological role of the remaining 53 non-BET bromodomains. Rapid growth of this research area has been accompanied by a greater understanding of the requirements for an effective bromodomain chemical probe and has led to a number of new non-BET bromodomain chemical probes being developed. Advances since December 2015 are discussed, highlighting the strengths/caveats of each molecule, and the value they add toward validating the non-BET bromodomains as tractable therapeutic targets.  相似文献   
42.
Metallurgical and Materials Transactions B - The process of obtaining titanium tetrachloride (TiCl4) from the quartz-leucoxene concentrate (QLC) from the Yaregskoe oil-titanium field was studied....  相似文献   
43.
Hassan  Lovelu  Khan  K. A. 《Microsystem Technologies》2020,26(3):1031-1041

The efficiency of any electric cell or battery is very important. To keep it in mind it has been studied the columbic efficiency, voltaic efficiency and energy efficiency of a PKL (Pathor Kuchi Leaf) Quasi Voltaic Cell or Modified Voltaic Cell. It was found that the columbic efficiency data illustrated that this efficiency was lower comparing to other efficiencies may be the absence of salt bridge or separator between the electrodes. Because, our designed and fabricated PKL cell does not have any salt bridge. So that the internal resistance is lower than the traditional voltaic cell and as a result more current was found. The voltage and current changes with time and I–V characteristics for PKL unit cell, module, panel and array have also been studied. It is shown that the voltaic and energy efficiency have been studied. However, the highest efficiency was obtained for 40% PKL sap with 5% secondary salt in 55% aqueous solution, which implies that the concentration of PKL juice can play an important role regarding efficiency. It was also found that the average energy efficiency was 97.43% and it was also found that the average voltaic efficiency was 57.29%. Finally, morphological study FESEM (Field Emission Scanning Electron Microscopy) has also been performed. It is seen that the results confirmed that Zn was deposited on the Cu surface during the electro deposition process in PKL solution. Using AAS, it has been measured the concentration of [Cu2+] as a reactant ion and the concentration of [Zn2+] as a product ion those have been tabulated and graphically discussed. The variation of pH has also been studied with time and which was also tabulated and graphically discussed.

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A layer-by-layer analysis of the structures, the phase compositions, and the defect substructures of differentially hardened rails has been carried by optical and transmission electron microscopy. It is found that the material volume of the rail head fillet is cooled faster than the volume located along the central axis.  相似文献   
47.
Wu  Li  Li  Jing  Fu  Caixia  Kühn  Bernd  Wang  Xiaolin 《Magma (New York, N.Y.)》2019,32(4):501-509
Magnetic Resonance Materials in Physics, Biology and Medicine - To investigate the value of using diffusion-weighted imaging (DWI) and intravoxel incoherent motion DWI (IVIM-DWI) to assess the...  相似文献   
48.
Metallurgical and Materials Transactions A - The influence of the chemical composition on the crystallization process, amorphous phase formation, and the anticorrosion properties of Al-Zr-Ni-Fe-Y...  相似文献   
49.
Fefelov  S. A.  Kazakova  L. P.  Bogoslovskiy  N. A.  Bylev  A. B.  Yakubov  A. O. 《Semiconductors》2020,54(4):450-453
Semiconductors - The current–voltage characteristics measured on Ge2Sb2Te5 thin films in the current mode are studied. The effect of multilevel recording is established when applying...  相似文献   
50.
Hussien  O. S.  Elamy  M. I. 《Strength of Materials》2020,52(3):470-479
Strength of Materials - The use of a damping system is one of the seismic protection systems that improve the seismic response of structures. The proposed methodology estimates the location (which...  相似文献   
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