全文获取类型
收费全文 | 10012篇 |
免费 | 760篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 137篇 |
综合类 | 26篇 |
化学工业 | 2510篇 |
金属工艺 | 207篇 |
机械仪表 | 228篇 |
建筑科学 | 486篇 |
矿业工程 | 43篇 |
能源动力 | 163篇 |
轻工业 | 1700篇 |
水利工程 | 59篇 |
石油天然气 | 17篇 |
无线电 | 718篇 |
一般工业技术 | 2657篇 |
冶金工业 | 293篇 |
原子能技术 | 76篇 |
自动化技术 | 1454篇 |
出版年
2023年 | 144篇 |
2022年 | 187篇 |
2021年 | 383篇 |
2020年 | 204篇 |
2019年 | 218篇 |
2018年 | 371篇 |
2017年 | 380篇 |
2016年 | 431篇 |
2015年 | 327篇 |
2014年 | 405篇 |
2013年 | 757篇 |
2012年 | 531篇 |
2011年 | 639篇 |
2010年 | 539篇 |
2009年 | 511篇 |
2008年 | 556篇 |
2007年 | 500篇 |
2006年 | 372篇 |
2005年 | 302篇 |
2004年 | 234篇 |
2003年 | 246篇 |
2002年 | 227篇 |
2001年 | 190篇 |
2000年 | 147篇 |
1999年 | 133篇 |
1998年 | 126篇 |
1997年 | 115篇 |
1996年 | 100篇 |
1995年 | 64篇 |
1994年 | 76篇 |
1993年 | 62篇 |
1992年 | 48篇 |
1991年 | 53篇 |
1990年 | 34篇 |
1989年 | 37篇 |
1988年 | 31篇 |
1987年 | 37篇 |
1986年 | 48篇 |
1985年 | 105篇 |
1984年 | 66篇 |
1983年 | 52篇 |
1982年 | 51篇 |
1981年 | 42篇 |
1980年 | 49篇 |
1979年 | 34篇 |
1978年 | 40篇 |
1976年 | 29篇 |
1973年 | 30篇 |
1943年 | 26篇 |
1925年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 437 毫秒
81.
Francesca Truzzi Camilla Tibaldi Anne Whittaker Silvia Dilloo Enzo Spisni Giovanni Dinelli 《International journal of molecular sciences》2021,22(1)
There is a need to assess the relationship between improved rheological properties and the immunogenic potential of wheat proteins. The present study aimed to investigate the in vitro effects of total protein extracts from three modern and two landrace Triticum aestivum commercial flour mixes, with significant differences in gluten strength (GS), on cell lines. Cytotoxicity and innate immune responses induced by wheat proteins were investigated using Caco-2 monocultures, two dimensional (2D) Caco-2/U937 co-cultures, and three dimensional (3D) co-cultures simulating the intestinal mucosa with Caco-2 epithelial cells situated above an extra-cellular matrix containing U937 monocytes and L929 fibroblasts. Modern wheat proteins, with increased GS, significantly reduced Caco-2 cell proliferation and vitality in monoculture and 2D co-cultures than landrace proteins. Modern wheat proteins also augmented Caco-2 monolayer disruption and tight junction protein, occludin, redistribution in 3D co-cultures. Release of interleukin-8 into the cell medium and increased U937 monocyte migration in both 2D and 3D co-cultures were similarly apparent. Immuno-activation of migrating U937 cells was evidenced from cluster of differentiation 14 (CD14) staining and CD11b-related differentiation into macrophages. The modern wheat proteins, with gluten polymorphism relatedness and increased GS, were shown to be more cytotoxic and immunogenic than the landrace wheat proteins. 相似文献
82.
Silvia Gazzin Matteo Dal Ben Michele Montrone Sri Jayanti Andrea Lorenzon Alessandra Bramante Cristina Bottin Rita Moretti Claudio Tiribelli 《International journal of molecular sciences》2021,22(1)
Bilirubin toxicity to the central nervous system (CNS) is responsible for severe and permanent neurologic damage, resulting in hearing loss, cognitive, and movement impairment. Timely and effective management of severe neonatal hyperbilirubinemia by phototherapy or exchange transfusion is crucial for avoiding permanent neurological consequences, but these therapies are not always possible, particularly in low-income countries. To explore alternative options, we investigated a pharmaceutical approach focused on protecting the CNS from pigment toxicity, independently from serum bilirubin level. To this goal, we tested the ability of curcumin, a nutraceutical already used with relevant results in animal models as well as in clinics in other diseases, in the Gunn rat, the spontaneous model of neonatal hyperbilirubinemia. Curcumin treatment fully abolished the landmark cerebellar hypoplasia of Gunn rat, restoring the histological features, and reverting the behavioral abnormalities present in the hyperbilirubinemic rat. The protection was mediated by a multi-target action on the main bilirubin-induced pathological mechanism ongoing CNS damage (inflammation, redox imbalance, and glutamate neurotoxicity). If confirmed by independent studies, the result suggests the potential of curcumin as an alternative/complementary approach to bilirubin-induced brain damage in the clinical scenario. 相似文献
83.
Silvia Saturio Alicja M. Nogacka Marta Surez Nuria Fernndez Laura Mantecn Leonardo Mancabelli Christian Milani Marco Ventura Clara G. de los Reyes-Gaviln Gonzalo Solís Silvia Arboleya Miguel Gueimonde 《International journal of molecular sciences》2021,22(7)
The establishment of the gut microbiota poses implications for short and long-term health. Bifidobacterium is an important taxon in early life, being one of the most abundant genera in the infant intestinal microbiota and carrying out key functions for maintaining host-homeostasis. Recent metagenomic studies have shown that different factors, such as gestational age, delivery mode, or feeding habits, affect the gut microbiota establishment at high phylogenetic levels. However, their impact on the specific bifidobacterial populations is not yet well understood. Here we studied the impact of these factors on the different Bifidobacterium species and subspecies at both the quantitative and qualitative levels. Fecal samples were taken from 85 neonates at 2, 10, 30, 90 days of life, and the relative proportions of the different bifidobacterial populations were assessed by 16S rRNA–23S rRNA internal transcribed spacer (ITS) region sequencing. Absolute levels of the main species were determined by q-PCR. Our results showed that the bifidobacterial population establishment is affected by gestational age, delivery mode, and infant feeding, as it is evidenced by qualitative and quantitative changes. These data underline the need for understanding the impact of perinatal factors on the gut microbiota also at low taxonomic levels, especially in the case of relevant microbial populations such as Bifidobacterium. The data obtained provide indications for the selection of the species best suited for the development of bifidobacteria-based products for different groups of neonates and will help to develop rational strategies for favoring a healthy early microbiota development when this process is challenged. 相似文献
84.
Th. Braun M. Wohlers T. Belz G. Nowitzke G. Wortmann Y. Uchida N. Pfänder R. Schlögl 《Catalysis Letters》1997,43(3-4):167-173
The influence of fullerenes and related support materials on the structural and catalytic properties of ruthenium was investigated.
Catalysts based on C60, raw fullerene black, extracted fullerene black, cathode deposit and graphite were prepared by an impregnation/activation
procedure with Ru3CO12. The local co-ordination sphere of the resulting highly dispersed X-ray amorphous ruthenium was investigated by means of
EXAFS. The dominating role of the presence of non-six-membered carbon rings on the structure and the stability of the Ru particles
will be illustrated.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
85.
Pekka Manninen Päivi Laakso Heikki Kallio 《Journal of the American Oil Chemists' Society》1995,72(9):1001-1008
This study demonstrates the usefulness of capillary supercritical fluid chromatography (SFC) for the characterization of triacylglycerols
of edible oils and fats. Triacylglycerols were separated according to the acyl carbon number and the degree of unsaturation
on a 25% cyanopropyl/25% phenyl/50% methylpolysiloxane stationary phase. Valuable information concerning the triacylglycerol
composition of berry oils was obtained, despite the overlapping of certain triacylglycerol peaks. Simultaneous analysis of
fat-soluble vitamins and triacylglycerols is not practical by capillary SFC with flame-ionization detection because of the
low concentration of naturally-occurring fat-soluble vitamins in edible oils. Therefore, higher loading of the sample, which
led to overloading of triacylglycerols, was required to get reasonable peaks for fat-soluble vitamins. The method was applied
to the characterization of triacylglycerols and tocopherols in sea buckthorn pulp and seed oil, and cloudberry seed oil without
any sample purification prior to SFC. In addition, the stationary phase proved useful for separating the more complex mixtures
of triacylglycerols found in milk fat and in fish oil. 相似文献
86.
H. Purnama F. Girgsdies T. Ressler J.H. Schattka R.A. Caruso R. Schomäcker R. Schlögl 《Catalysis Letters》2004,94(1-2):61-68
Steam reforming of methanol for production of hydrogen can be carried out over copper based catalyst. In the work presented here, the catalytic properties of a CuO/ZrO2 catalyst (8.5wt%) synthesised by a templating technique were investigated with respect to activity, long term stability, CO formation, and response to oxygen addition to the feed. The results were obtained using a fixed bed reactor and compared to a commercial methanol synthesis catalyst CuO/ZnO/Al2O3. It is shown that, depending on the time on stream, the temporary addition of oxygen to the feed has a beneficial effect on the activity of the CuO/ZrO2 catalyst. After activation, the CuO/ZrO2 catalyst is found to be more active (per copper mass) than the CuO/ZnO/Al2O3 system, more stable during time on stream (measured up to 250h), and to produce less CO. Structural characterisation by means of X-ray powder diffraction (XRD) and X-ray absorption spectroscopy (XAS) reveals that the catalyst (as prepared) consists of crystalline, tetragonal zirconia with small domain sizes (about 60Å) and small/disordered crystallites of CuO. 相似文献
87.
The single NO bond in various ethers derived from 1-hydroxybenzo(d)-1,2,3-triazoles is reduced at mercury cathodes in a 2-electron process giving rise to the non-substituted benzotriazole and a corresponding primary alcohol. Controlled-potential electrolysis actually resulted in isolating the products of the above type eg benzotriazole and 2-piperidinoethanol. Cathodic reduction of non-substituted benzotriazole in acid media proceeds evidently via a chemical reaction between benzotriazole and hydrogen obtained by the catalytic reduction of hydrogen ions at the mercury electrode. 相似文献
88.
Chia seeds as a source of natural lipid antioxidants 总被引:8,自引:0,他引:8
M. Silvia Taga E. E. Miller D. E. Pratt 《Journal of the American Oil Chemists' Society》1984,61(5):928-931
Chia (Salvia sp) seeds were investigated as a source of natural lipid antioxidants. Methanolic and aqueous extracts of defatted chia seeds
possessed potent antioxidant activity. Analysis of 2 batches of chia-seed oils demonstrated marked difference in the fatty
acid composition of the oils. In both batches, the oils had high concentrations of polyunsaturated fatty acids. The major
antioxidant activity in the nonhydrolyzed extract was caused by flavonol glycosides, chlorogenic acid (7.1 × 10−4 mol/kg of seed) and caffeic acid (6.6 × 10−3 m/kg). Major antioxidants of the hydrolyzed extracts were flavonol aglycones/kaempferol (1.1 × 10−3 m/kg), quercetin (2.0 × 10−4 m/kg) and myricetin (3.1 × 10−3 m/kg); and caffeic acid (1.35 × 10−2 m/kg). Two methods were used to measure antioxidant activities. Both were based on measuring bleaching ofβ-carotene in the coupled oxidation ofβ-carotene and linoleic acid in the presence of added antioxidants. 相似文献
89.
Jeannette Aumo Johanna Lilja Päivi Mäki-Arvela Tapio Salmi Mats Sundell Hanna Vainio Dmitry Yu. Murzin 《Catalysis Letters》2002,84(3-4):219-224
A polymer-supported Pd catalyst was investigated in hydrogenation of citral (3,7-dimethyl-2,6-octadienal), which is a stereoisomer with an isolated and a conjugated double bond as well as a carbonyl group. The catalyst was a fibrous polymer-supported catalyst modified with functional groups and immobilized metals. A comparison of the polymer-supported catalyst with conventional catalysts was made. 相似文献
90.
Thomas Bürgi Fachri Atamny Axel Knop‐Gericke Michael Hävecker Thomas Schedel‐Niedrig Robert Schlögl Alfons Baiker 《Catalysis Letters》2000,66(3):109-112
The adsorption of ethyl pyruvate on Pt(111) has been studied by in situ XANES measurements in the presence and absence of
hydrogen. Depending on the hydrogen and ethyl pyruvate pressure, the C and O K‐edge spectra exhibit distinctly different angular
dependence. Without hydrogen ethyl pyruvate is oriented preferentially perpendicular to the surface, indicating bonding via
the O lone pairs. In the presence of hydrogen the mean orientation is more tilted towards the surface. Likely, ethyl pyruvate
also interacts with Pt via its π system under these conditions. The observed angle‐dependent shift of the energy of the π*
and σ* resonances indicates the coexistence of differently adsorbed ethyl pyruvate species. The experimental findings demonstrate
the importance of the in situ approach for unraveling the adsorption mode of ethyl pyruvate in the enantioselective hydrogenation
over cinchona‐alkaloid‐modified Pt.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献