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排序方式： 共有401条查询结果，搜索用时 156 毫秒
41.
KarthikRanganathan JagadeesanRajamanickam 《今日电子》2004,(3):36-37
典型的网络系统包括一个或多个用于监视数据平面分组处理的控制平面CPU。通过CPU进行的控制更新将导致存储于网络搜索引擎(NSE)和相联SRAM中的路由表和政策表的更新。在数据平面中,NSE和SRAM通过诸如网络处理机论坛的LookAside-1(LA-1)接口等高速接口连接至网络处理单元(NPU)。从外部CPU至NSE和SRAM的控制平面更新信息可以经由带内线路(即在NPU内部并通过NPU的LA-1接口)来传送。 相似文献
42.
Sonia Domingos-Pereira Karthik Sathiyanadan Lenka Polak Jacques-Antoine Haefliger Martina Schmittnaegel Carola H. Ries Patrice Jichlinski Beat Roth Laurent Derr Denise Nardelli-Haefliger 《International journal of molecular sciences》2023,24(1)
Bacillus Calmette-Guérin (BCG) instillations for the treatment of non-muscle-invasive bladder cancer patients can result in significant side effects and treatment failure. Immune checkpoint blockade and/or decreasing tumor-infiltrating myeloid suppressor cells may be alternative or complementary treatments. Here, we have characterized immune cell infiltration and chemoattractant molecules in mouse orthotopic MB49 bladder tumors. Our data show a 100-fold increase in CD45+ immune cells from day 5 to day 9 tumors including T cells and mainly myeloid cells. Both monocytic myeloid-derived suppressor-cells (M-MDSC) and polymorphonuclear (PMN)-MDSC were strongly increased in day 9 tumors, with PMN-MDSC representing ca. 70% of the myeloid cells in day 12 tumors, while tumor associated macrophages (TAM) were only modestly increased. The kinetic of PD-L1 tumor expression correlated with published data from patients with PD-L1 expressing bladder tumors and with efficacy of anti-PD-1 treatment, further validating the orthotopic MB49 bladder-tumor model as suitable for designing novel therapeutic strategies. Comparison of chemoattractants expression during MB49 bladder tumors grow highlighted CCL8 and CCL12 (CCR2-ligands), CCL9 and CCL6 (CCR-1-ligands), CXCL2 and CXCL5 (CXCR2-ligands), CXCL12 (CXCR4-ligand) and antagonist of C5/C5a as potential targets to decrease myeloid suppressive cells. Data obtained with a single CCR2 inhibitor however showed that the complex chemokine crosstalk would require targeting multiple chemokines for anti-tumor efficacy. 相似文献
43.
Karthik Ramamurthy Anirudh Muthuswamy Nagharjun Mathimariappan Gugan S. Kathiresan 《Concurrency and Computation》2023,35(26):e7834
The preferred modality for the identification of skin disease has predominantly been dermoscopy. Skin lesion identification is the primary diagnostic basis for the dermatologist to evaluate the severity and impact of the disease. Current diagnostic procedures for the identification of skin lesions may be subjected to misdiagnosis among observers. Also, these procedures are conventionally labour-intensive and prone to delays in treatment. Deep learning has proven to be beneficial for automated computer-aided diagnosis in the medical field. This research presents a two-stage approach involving segmentation and classification architectures for the effective detection of skin disease. The proposed approach aims to combine the architectural benefits of residual learning with the contextual retention of atrous convolutions. The classification is performed on seven different classes of skin lesions namely, melanoma (MEL), melanocytic nevus (NV), basal cell carcinoma (BCC), actinic keratosis/Bowen's disease (AKIEC), benign keratosis (BKL), dermatofibroma (DF), and vascular lesion (VASC). To the best of our knowledge, this is the first research that reports the impact of a two-staged detection network using atrous residual convolutions for these seven classes. Experimental observations indicate that the proposed model is characteristically balanced in terms of inter-class performance, with precise segmentation. The proposed network was trained with the HAM10000 dataset and reported a classification accuracy and precision of 89.27% and 89.06%, respectively. 相似文献
44.
Naveenkumar Palanimuthu;Mohan Raj Subramaniam;Muthu Austeria P.;Preetam Kumar Sharma;Vinoth Ramalingam;Karthik Peramaiah;Shanmugam Ramakrishnan;Geun Ho Gu;Eileen Hao Yu;Dong Jin Yoo; 《Small (Weinheim an der Bergstrasse, Germany)》2024,20(40):2400913
Electrochemical carbon dioxide reduction reaction (ECO2RR) is a promising approach to synthesize fuels and value-added chemical feedstocks while reducing atmospheric CO2 levels. Here, high surface area cerium and sulfur-doped hierarchical bismuth oxide nanosheets (Ce@S-Bi2O3) are develpoed by a solvothermal method. The resulting Ce@S-Bi2O3 electrocatalyst shows a maximum formate Faradaic efficiency (FE) of 92.5% and a current density of 42.09 mA cm−2 at −1.16 V versus RHE using a traditional H-cell system. Furthermore, using a three-chamber gas diffusion electrode (GDE) reactor, a maximum formate FE of 85% is achieved in a wide range of applied potentials (−0.86 to −1.36 V vs RHE) using Ce@S-Bi2O3. The density functional theory (DFT) results show that doping of Ce and S in Bi2O3 enhances formate production by weakening the OH* and H* species. Moreover, DFT calculations reveal that *OCHO is a dominant pathway on Ce@S-Bi2O3 that leads to efficient formate production. This study opens up new avenues for designing metal and element-doped electrocatalysts to improve the catalytic activity and selectivity for ECO2RR. 相似文献
45.
S. Karthik Robin Singh Bhadoria Jeong Gon Lee Arun Kumar Sivaraman Sovan Samanta A. Balasundaram Brijesh Kumar Chaurasia S. Ashokkumar 《计算机、材料和连续体（英文）》2022,72(1):243-259
Data is always a crucial issue of concern especially during its prediction and computation in digital revolution. This paper exactly helps in providing efficient learning mechanism for accurate predictability and reducing redundant data communication. It also discusses the Bayesian analysis that finds the conditional probability of at least two parametric based predictions for the data. The paper presents a method for improving the performance of Bayesian classification using the combination of Kalman Filter and K-means. The method is applied on a small dataset just for establishing the fact that the proposed algorithm can reduce the time for computing the clusters from data. The proposed Bayesian learning probabilistic model is used to check the statistical noise and other inaccuracies using unknown variables. This scenario is being implemented using efficient machine learning algorithm to perpetuate the Bayesian probabilistic approach. It also demonstrates the generative function for Kalman-filer based prediction model and its observations. This paper implements the algorithm using open source platform of Python and efficiently integrates all different modules to piece of code via Common Platform Enumeration (CPE) for Python. 相似文献
46.
An experimental study is conducted to evaluate the use of rubber seed oil with diesel at a proportion of 20% by volume (RSO20) in a constant speed (1500?rpm) direct injected four-stroke air-cooled single-cylinder compression ignition engine at different injection timings (24°, 27°, 30°, 33° bTDC (before top dead centre)). A series of tests were conducted at various engine load conditions at the rated power of 5.9?kW. The injection pressure was maintained at 200?bar. As a result of investigations, at the full load condition, the brake thermal efficiency of RSO20 at 30° bTDC is high compared with other injection timings and brake energy fuel consumption is increased when advancing injection timing. There is a significant reduction in unburned hydrocarbon emission and carbon monoxide emission, and the oxides of nitrogen emission (NOx) is increased when advancing the injection timing. 相似文献
47.
In the present study, a natural dye is extracted from red prickly pear fruit (Opuntia ficus-indica) and is applied on the silk fabric using natural (myrobalan) and synthetic (copper sulphate) mordant. The dyeing of silk fabric is carried out using two different routes, namely, pre-mordanting and post-mordanting at different mordant concentrations and the dyed silk fabric was evaluated for its colour strength, colour fastness and antibacterial properties. The colour strength (K/S) was found to be higher in the post-mordant-processed fabric with the use of synthetic mordant compared to pre-mordanting and with the use of natural mordants and highest colour strength was observed at the mordant concentration of 6% and at a pH of 6 in all the cases. The colour fastness properties of the fabric also found to be improved in post-mordanting with use of synthetic mordants. The antimicrobial efficacy was also evaluated both in terms of zone of inhibition (qualitative analysis [SN195920]) and bacterial reduction % (quantitative analysis [AATCC 100]), against dyed silk fabric samples against on Staphylococcus aureus and Escherichia coli. 相似文献
48.
Tinkle Chugh Nirupam Chakraborti Karthik Sindhya Yaochu Jin 《Materials and Manufacturing Processes》2017,32(10):1172-1178
A new data-driven reference vector-guided evolutionary algorithm has been successfully implemented to construct surrogate models for various objectives pertinent to an industrial blast furnace. A total of eight objectives have been modeled using the operational data of the furnace using 12 process variables identified through a principal component analysis and optimized simultaneously. The capability of this algorithm to handle a large number of objectives, which has been lacking earlier, results in a more efficient setting of the operational parameters of the furnace, leading to a precisely optimized hot metal production process. 相似文献
49.
Karthik Krishnan Manoharan Muruganathan Tohru Tsuruoka Hiroshi Mizuta Masakazu Aono 《Advanced functional materials》2017,27(10)
A detailed understanding of the conductance quantization and resistive switching phenomena in redox‐based memories is crucial for realizing atomic‐scale memory devices and for finding the adequate design principles on which they can be based. Here, the emergence of quantized conductance states and their correlation with resistive switching characteristics in polymer‐based atomic switches are investigated using combinations of current–voltage measurements and first‐principles density functional theory (DFT) simulations. Various conductance states, including integer and half‐integer multiples of a single atomic point contact and fractional conductance variations, are observed in an Ag/polyethylene oxide/Pt device under sweeping of bias voltage. Moreover, highly controllable and reproducible quantized conductance behaviors by tuning the voltage sweep rate and the sweep voltage range, suggesting well‐controlled formation of the atomic point contact, are demonstrated. The device also exhibits longer retention times for higher conductance states. The DFT simulations reveal the transmission eigenstate of geometrically optimized atomic point contact structures and the impact of the atomic configurations and structural stability on the conductance state, which also explains their resistive switching behaviors. The well‐defined, multiple quantized conductance states observed in these polymer‐based atomic switches show promise for the development of new multilevel memory devices. 相似文献
50.
Jeong Dong Kim Parsian K. Mohseni Karthik Balasundaram Srikanth Ranganathan Jayavel Pachamuthu James J. Coleman Xiuling Li 《Advanced functional materials》2017,27(12)
Metal‐assisted chemical etching (MacEtch) has shown tremendous success as an anisotropic wet etching method to produce ultrahigh aspect ratio semiconductor nanowire arrays, where a metal mesh pattern serves as the catalyst. However, producing vertical via arrays using MacEtch, which requires a pattern of discrete metal disks as the catalyst, has often been challenging because of the detouring of individual catalyst disks off the vertical path while descending, especially at submicron scales. Here, the realization of ordered, vertical, and high aspect ratio silicon via arrays by MacEtch is reported, with diameters scaled from 900 all the way down to sub‐100 nm. Systematic variation of the diameter and pitch of the metal catalyst pattern and the etching solution composition allows the extraction of a physical model that, for the first time, clearly reveals the roles of the two fundamental kinetic mechanisms in MacEtch, carrier generation and mass transport. Ordered submicron diameter silicon via arrays with record aspect ratio are produced, which can directly impact the through‐silicon‐via technology, high density storage, photonic crystal membrane, and other related applications. 相似文献