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排序方式: 共有263条查询结果,搜索用时 15 毫秒
71.
Viktor Hlav
Radka Vclavíkov Veronika Brynychov Renata Koevnikovov Katerina Kope
kov David Vrna Jií Gatk Pavel Sou
ek 《International journal of molecular sciences》2020,21(24)
Breast cancer is the most common cancer in women in the world. The role of germline genetic variability in ATP-binding cassette (ABC) transporters in cancer chemoresistance and prognosis still needs to be elucidated. We used next-generation sequencing to assess associations of germline variants in coding and regulatory sequences of all human ABC genes with response of the patients to the neoadjuvant cytotoxic chemotherapy and disease-free survival (n = 105). A total of 43 prioritized variants associating with response or survival in the above testing phase were then analyzed by allelic discrimination in the large validation set (n = 802). Variants in ABCA4, ABCA9, ABCA12, ABCB5, ABCC5, ABCC8, ABCC11, and ABCD4 associated with response and variants in ABCA7, ABCA13, ABCC4, and ABCG8 with survival of the patients. No association passed a false discovery rate test, however, the rs17822931 (Gly180Arg) in ABCC11, associating with response, and the synonymous rs17548783 in ABCA13 (survival) have a strong support in the literature and are, thus, interesting for further research. Although replicated associations have not reached robust statistical significance, the role of ABC transporters in breast cancer should not be ruled out. Future research and careful validation of findings will be essential for assessment of genetic variation which was not in the focus of this study, e.g., non-coding sequences, copy numbers, and structural variations together with somatic mutations. 相似文献
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73.
Summary This article analyses the changes in development of journals on social sciences and humanities in Ukraine and shows the results
of the comparative analysis of journals on social sciences and humanities in Ukraine, and journals in the world included in
relevant databases of the US Institute for Scientific Information (Philadelphia). 相似文献
74.
75.
Panayiotis Kolios Vasilis Friderikos Katerina Papadaki 《Mobile Networks and Applications》2012,17(2):267-280
Energy efficiency and capacity maximization are two of the most challenging issues to be addressed by current and future cellular
networks. Significant research effort has been placed recently in reducing the total energy consumption while maintaining
or improving capacity either by introducing more efficient hardware components or by developing innovative software techniques.
In this paper we investigate a novel networking paradigm to address the aforementioned problems. By capitalizing on the inherent
delay tolerance of Internet type services, we argue that significant energy savings can be achieved by postponing the communication
of information for a later time instance with better networking conditions. We device decentralized algorithms for the proposed
postponement schemes and show the superior performance of implementing such schemes over the traditional cellular operation. 相似文献
76.
Ondrej Cernohorsky Karel Zdansky Jiri Zavadil Pavel Kacerovsky Katerina Piksova 《Nanoscale research letters》2011,6(1):410
Layers of palladium (Pd) nanoparticles on indium phosphide (InP) were prepared by electrophoretic deposition from the colloid solution of Pd nanoparticles. Layers prepared by an opposite polarity of deposition showed different physical and morphological properties. Particles in solution are separated and, after deposition onto the InP surface, they form small aggregates. The size of the aggregates is dependent on the time of deposition. If the aggregates are small, the layer has no lateral conductance. Forward and reverse I-V characteristics showed a high rectification ratio with a high Schottky barrier height. The response of the structure on the presence of hydrogen was monitored. 相似文献
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78.
Microwave‐synthesized magnetic chitosan microparticles for the immobilization of yeast cells 下载免费PDF全文
Ivo Safarik Kristyna Pospiskova Zdenka Maderova Eva Baldikova Katerina Horska Mirka Safarikova 《Yeast (Chichester, England)》2015,32(1):239-243
An extremely simple procedure has been developed for the immobilization of Saccharomyces cerevisiae cells on magnetic chitosan microparticles. The magnetic carrier was prepared using an inexpensive, simple, rapid, one‐pot process, based on the microwave irradiation of chitosan and ferrous sulphate at high pH. Immobilized yeast cells have been used for sucrose hydrolysis, hydrogen peroxide decomposition and the adsorption of selected dyes. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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80.
Anne-Marie Reißner Susanne Struck Katerina Alba Cristina Proserpio Roberto Foschino Charlotta Turner Isabel Hernando Susann Zahn Harald Rohm 《International Journal of Food Science & Technology》2021,56(10):5007-5016
Juice-pressing residues, among them blackcurrant pomace, are valuable materials for being upgraded in food products. Their excellent nutritional profiles in line with their functional properties allow a wide range of applications. The current study was performed to evaluate the overall liking of a pomace-enriched thin crispy-baked bread product in five European countries, and to obtain suggestions for improvements. Moreover, data on the frequency of snack consumption, openness to new foods and an opinion on residues in food applications were acquired. Four hundred and sixty-six consumers from United Kingdom, Spain, Sweden, Italy and Germany were involved. On a 9-point hedonic scale, the pomace cracker was rated towards the direction of liking with 5.94 ± 1.90 on average. Contingency tables showed that the overall-liking correlated highly significant (p < 0.01) with the country of origin and sex of the respondents and their openness to new products. Significantly higher liking scores were provided by British and Spanish consumers and, among these respondents, savoury snacks were stated to be consumed most frequently. Therefore, the snack consumption frequency also appeared to be a driver for cross-national differences in hedonic responses. The consent for using pomace in food products was remarkably high (>90%) in all countries and stresses consumer awareness in terms of healthy longevity and sustainability. 相似文献