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51.
Distributed message relaying is an important function of a peer-to-peer system to discover service providers. Existing search protocols in unstructured peer-to-peer systems create huge burden on communications, cause long response time, or result in unreliable performance. Moreover, with self-interested peers, these systems are vulnerable to the free-riding problem. In this paper we present an incentive mechanism that not only mitigates the free-riding problem, but also achieves good system efficiency in message relaying for peer discovery. In this mechanism promised rewards are passed along the message propagation process. A peer is rewarded if a service provider is found via a relaying path that includes this peer. The mechanism allows peers to rationally trade-off communication efficiency and reliability while maintaining information locality. We provide some analytic insights to the symmetric Nash equilibrium strategies of this game, and an approximate approach to calculate this equilibrium. Experiments show that this incentive mechanism brings a system utility generally higher than breadth-first search and random walks, based on both the estimated utility from our approximate equilibrium and the utility generated from learning in the incentive mechanism. 相似文献
52.
Several theoretical and experimental studies are developed in order to simplify the construction of filters based on Mellin radial harmonics (MRH) for scale-invariant pattern recognition. A real filter based on MRH is designed. The impulse response of the filter is a hermitic function, obtained by a suitable modification of a MRH component. This real filter has the same scale invariance as the conventional complex MRH filters, with the main advantage of its simplicity. Both computer simulations and optical experiments are presented. 相似文献
53.
The common multichannel system for recognizing colored images is replaced by a color-encoded single-channel system. Amethod inspired by the Munsell color system is used for encoding the different colors as phase and amplitude functions. It is shown that for many practical cases the phase information part of the color code is sufficient for obtaining good results. An implementation based on a liquid-crystal television panel that works in a phase-modulation mode is suggested. Computer simulations that demonstrate the capabilities of the suggested method are given as well as a comparison with previously published multichannel performance. 相似文献
54.
Guilherme Ferreira Gomes Camila Aparecida Diniz Sebastião Simões da CunhaJr. Antonio Carlos AncelottiJr. 《Journal of Failure Analysis and Prevention》2017,17(4):740-749
The investigation of possible failures in composite materials is a matter of very great importance, and the Tsai-Wu criterion is an effective criterion for analyzing those flaws in anisotropic materials and defining whether the material at a given load will or will not suffer structural failure. In this study, an optimization procedure is proposed to minimize the maximum value of Tsai-Wu of laminated composite tubes subject to axial loading. Artificial neural networks and genetic algorithms are chosen as optimization tools. The results of this study show that the developed algorithm converges faster. Then, the maximum Tsai-Wu value is used as the objective function and the fiber orientations are the constraints in the optimization process. The results yielded by them are compared and discussed. Optimal results are compared with respect to the usual initial design. The design approach is recommended for structures where composites are the key load-carrying members such as orthopedic prosthesis. 相似文献
55.
Organ‐On‐A‐Chip: Biomechanical Strain Exacerbates Inflammation on a Progeria‐on‐a‐Chip Model (Small 15/2017) 下载免费PDF全文
56.
This paper presents a generalized layerwise higher-order shear deformation theory for laminated composite and sandwich plates. We exploit a higher-order shear deformation theory in each layer such that the continuity of the displacement and transverse shear stresses at the layer interfaces is ensured. Thanks for enforcing the continuity of the displacement and transverse shear stresses at an inner-laminar layer, the minimum number of variables is retained from the present theory in comparison with other layerwise theories. The method requires only five variables, the same as what obtained from the first- and higher-order shear deformation theories. In comparison with the shear deformation theories based on the equivalent single layer, the present theory is capable of producing a higher accuracy for inner-laminar layer shear stresses. The free boundary conditions of transverse shear stresses at the top and bottom surfaces of the plate are fulfilled without any shear correction factors. The discrete system equations are derived from the Galerkin weak form, and the solution is obtained by isogeometric analysis (IGA). The discrete form requires the C1 continuity of the transverse displacement, and hence NURBS basis functions in IGA naturally ensure this condition. The laminated composite and sandwich plates with various geometries, aspect ratios, stiffness ratios and boundary conditions are studied. The obtained results are compared with the 3D elasticity solution, the analytical as well as numerical solutions based on various plate theories. 相似文献
57.
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59.
Engineered Multifunctional Albumin‐Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin 下载免费PDF全文
João P. Martins Roberto D'Auria Dongfei Liu Flavia Fontana Mónica P. A. Ferreira Alexandra Correia Marianna Kemell Karina Moslova Ermei Mäkilä Jarno Salonen Luca Casettari Jouni Hirvonen Bruno Sarmento Hélder A. Santos 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(27)
The last decade has seen remarkable advances in the development of drug delivery systems as alternative to parenteral injection‐based delivery of insulin. Neonatal Fc receptor (FcRn)‐mediated transcytosis has been recently proposed as a strategy to increase the transport of drugs across the intestinal epithelium. FcRn‐targeted nanoparticles (NPs) could hijack the FcRn transcytotic pathway and cross the epithelial cell layer. In this study, a novel nanoparticulate system for insulin delivery based on porous silicon NPs is proposed. After surface conjugation with albumin and loading with insulin, the NPs are encapsulated into a pH‐responsive polymeric particle by nanoprecipitation. The developed NP formulation shows controlled size and homogeneous size distribution. Transmission electron microscopy (TEM) images show successful encapsulation of the NPs into pH‐sensitive polymeric particles. No insulin release is detected at acidic conditions, but a controlled release profile is observed at intestinal pH. Toxicity studies show high compatibility of the NPs with intestinal cells. In vitro insulin permeation across the intestinal epithelium shows approximately fivefold increase when insulin is loaded into FcRn‐targeted NPs. Overall, these FcRn‐targeted NPs offer a toolbox in the development of targeted therapies for oral delivery of insulin. 相似文献
60.
On the Structure of Amorphous Mesoporous Silica Nanoparticles by Aberration‐Corrected STEM 下载免费PDF全文
Sebastian Calderon V Tânia Ribeiro José Paulo S. Farinha Carlos Baleizão Paulo J. Ferreira 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(40)
Mesoporous silica materials have demonstrated a vast spectrum of applications, stimulating an intensive field of study due to their potential use as nanocarriers. Nonetheless, when produced at the nanoscale, their structural characterization is hindered due to the re‐arrangement of the pores. To address this issue, this work combines molecular dynamics simulations with electron microscopy computer simulations and experimental results to provide an insight into the structure of amorphous mesoporous silica nanoparticles. The amorphous silica model is prepared using a simple melt‐quench molecular dynamics method, while the reconstruction of the mesoporous nanoparticles is carried out using a methodology to avoid false symmetry in the final model. Simulated scanning transmission electron microscopy images are compared with experimental images, revealing the existence of structural domains, created by the misalignment of the pores to compensate the surface tension of these spherical nanoparticles. 相似文献