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51.
1. The aim of the present study was to investigate the involvement of GTP-binding protein in the contractile response induced by activation of protein kinase C (PKC) in isolated rat aorta. The rats were treated with islet-activating protein (IAP) for 4 days prior to the experiments. 2. In the aorta from control rats, phorbol 12-myristate 13-acetate (PMA) produced biphasic contractions; twitch contraction superimposed on the slowly developing contraction. The twitch contraction was abolished by the removal of external Ca2+ or by treatment with nicardipine. In the aorta pretreated with IAP, PMA produced only a slowly developing contraction, and no twitch contraction was induced. 3. The application of Ca2+ to aortic strips in a Ca(2+)-free solution, that had been treated with 10(-6) M PMA caused concentration-dependent contraction, and the contraction was completely inhibited by IAP. 4. Pretreatment with IAP inhibited Ca(2+)-induced contraction of the aorta in Ca(2+)-free medium in the presence of 10(-6) M clonidine, but did not affect the Ca(2+)-induced contraction in the medium treated with 10(-6) M phenylephrine and 10(-7) M nicardipine. 5. These results suggest that the activation of PKC by PMA produces biphasic contractions in the rat aorta. The twitch contraction may be induced by the activation of voltage-dependent Ca(2+)-channels and the activation may be regulated by IAP-sensitive GTP-binding protein. 相似文献
52.
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54.
The effects of the muscarinic receptor agonist, carbamylcholine chloride (carbachol), on gastrin release and gastrin mRNA levels in human antral mucosa (n = 15) were determined. During a-2-h incubation period, carbachol (10(-6)-10(-4) M) decreased gastrin mRNA levels to 71 +/- 8% (10(-6) M), 40 +/- 8% (10(-5) M), and 33 +/- 5% (10(-4) M) of control levels. Carbachol (10(-5) M) decreased intracellular gastrin (from 1634 +/- 103 to 1272 +/- 126 pg/mg tissue protein), while it increased gastrin release into the medium (from 609 +/- 48 to 918 +/- 68 pg/ml per mg tissue protein). After 6- and 9-h culture, carbachol gradually increased gastrin mRNA levels, by 96 +/- 12% and 126 +/- 23%, respectively. Atropine sulfate (10(-5) M) completely inhibited the carbachol-induced changes. Cycloheximide markedly decreased tissue gastrin concentration, but increased gastrin mRNA levels, whereas it had no effects on gastrin release. These findings suggested that carbachol may have a time-related biphasic action on human antral gastrin biosynthesis. 相似文献
55.
Yoshihiko Kitagawa Kenji Ikeuchi Toshio Kuroda Yukinobu Matsushita Kazuyuki Suenaga Takeshi Hidaka Hideaki Takauchi 《Journal of Materials Science》2008,43(1):12-22
The effect of reheating by following passes on the hydrogen embrittlement of MAG weld metal for HT780 class steels has been
investigated by using specimens subjected to simulated thermal cycles. The hydrogen-charged specimens exhibited transgranular
quasi-cleavage fracture and intergranular fracture along prior austenite grain boundaries on slow strain rate tensile (SSRT)
tests, depending on the reheated temperature and charged hydrogen content. The reduction in elongation of hydrogen-charged
specimens became more significant when intergranular fracture occurred. When specimens in as-welded state and precedently
reheated at coarse grained HAZ temperature of 1,623 K were reheated at a tempering temperature of 873 K, significant amount
of intergranular fracture occurred at charged hydrogen contents above 3 ppm in spite of the decrease in hardness. The specimen
reheated at 1,173 K showed no intergranular fracture even after receiving the reheating at 873 K at a hydrogen content of
6 ppm, suggesting the strong influence of the prior austenite grain size on the hydrogen-induced intergranular embrittlement.
The measurement of hydrogen content desorbed from the hydrogen-charged specimen at room temperature suggested that the intergranular
fracture caused by the reheating at 873 K was associated with an increase in susceptibility to hydrogen embrittlement of the
prior austenite grain boundary itself rather than a decrease in the amounts of trapping sites such as dislocation and retained
austenite. 相似文献
56.
Atomic chains and crystal of iodine were successfully generated in a controlled manner inside single-walled carbon nanotubes (SWNTs). The structure is strongly dependent on the diameter of SWNTs; the single, double, and triple helical structures became quite stable when the diameter of SWNTs matches the certain size. More than three chains of iodine are not very stable, and they often crystallize inside the carbon nanotube when the diameter is larger than 1.45 nm. The crystallization or phase transition in a confined nanospace is thus directly observed, and there is indeed a critical size of the hollow nanospace for the stable formation of the atomic chains of iodine. 相似文献
57.
Kay Suenaga Rodrigo Picos Sebastià Bota Miquel Roca Eugeni Isern Eugeni García 《Journal of Electronic Testing》2007,23(6):605-612
A module to perform a built-in self-test in CMOS RF receivers is presented. The module is associated with a test strategy
consisting of measuring the main performance parameters of the single building blocks individually. Circuitry overhead, however,
is kept low by using some blocks as part of the test set-up and reusing them. The test overhead has also been reduced by replacing
direct determination of performance parameters with their estimation. The test methodology has been applied to a mixer in
the first down conversion stage of a GSM receiver, estimating its conversion gain, 1dB compression and third-order interception
points. Using the output of the IF amplifier as the only testing point, the rms errors in the estimation of the above mentioned
parameters are 1.5, 3.0 and 2.7%, respectively.
相似文献
Eugeni GarcíaEmail: |
58.
Bichoutskaia E Liu Z Kuganathan N Faulques E Suenaga K Shannon IJ Sloan J 《Nanoscale》2012,4(4):1190-1199
Low-voltage aberration-corrected transmission electron microscopy (AC-TEM) of discrete Lindqvist [W(6)O(19)](2-) polyoxometalate ions inserted from an ethanolic solution of [NBu(4)](2)[W(6)O(19)] into double walled carbon nanotubes (DWNTs) allows a higher precision structural study to be performed than previously reported. W atom column separations within the constituent W(6) tungsten cage can now be visualized with sufficient clarity that reliable correlation with structural predictions from density functional theory (DFT) can be achieved. Calculations performed on [W(6)O(19)](2-) anions encapsulated in carbon nanotubes show good agreement with measured separations between pairs of W(2) atom columns imaged within equatorial WO(6) polyhedral pairs and also single W atom positions located within individual axial WO(6) octahedra. Structural data from the tilted chiral encapsulating DWNT were also determined simultaneously with the anion structural measurements, allowing the influence of the conformation of the encapsulating tubule to be included in the DFT calculation and compared against that of other candidate encapsulating nanotubes. Additional DFT calculations performed using Li(+) cations as a model for the [NBu(4)](+) counterions indicate that the latter may help to induce charge transfer between the DWNT and the [W(6)O(19)](2-) ion and this may help to constrain the motion of the ion in situ. 相似文献
59.
A. N. Iyer R. Jammy U. Balachandran M. Suenaga P. Haldar 《Journal of Electronic Materials》1995,24(12):1873-1876
Long lengths of mono-and multifilament Ag-clad BSCCO superconductors were fabricated by the powder-in-tube technique. Critical
current density (Jc) up to 12,000 A/cm2 has been achieved in an 850 m long multicore conductor. Long length conductors were formed into pancake-shaped coils by the
wind-and-react approach. Test magnets were then fabricated by stacking the pancake coils and connecting them in series. The
magnets were characterized as a function of applied magnetic field at various temperatures. A test magnet, fabricated with
≈770 m of BSCCO tape, generated fields of ≈1 T at 4.2K and ≈ 0.6 T at 27K, both in an applied background field of 20 T. Additionally,
the strain tolerance of both mono-and multifilament conductors at 77K in 0.5 T applied field has been studied. We observed
that multifilament conductors have better strain tolerance than monofilament tapes, retaining more than 90% of the initial
critical current (at 0.5 T) with strain ≥1%. 相似文献
60.
2D Materials: Large‐Area and High‐Quality 2D Transition Metal Telluride (Adv. Mater. 3/2017)
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Jiadong Zhou Fucai Liu Junhao Lin Xiangwei Huang Juan Xia Bowei Zhang Qingsheng Zeng Hong Wang Chao Zhu Lin Niu Xuewen Wang Wei Fu Peng Yu Tay‐Rong Chang Chuang‐Han Hsu Di Wu Horng‐Tay Jeng Yizhong Huang Hsin Lin Zexiang Shen Changli Yang Li Lu Kazu Suenaga Wu Zhou Sokrates T. Pantelides Guangtong Liu Zheng Liu 《Advanced materials (Deerfield Beach, Fla.)》2017,29(3)