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51.
Male Sprague-Dawley rats were fed a cholesterol-free (Exp. 1) or cholesterol-supplemented (Exp. 2) diet containing 20% casein
(control group) or 15% defatted squid and 5% casein (defatted squid group), as protein, for 14 d. Serum and hepatic cholesterol
concentrations were lower in rats fed defatted squid than in those fed casein in both cholesterol-free (−20%, P<0.05 and −15%, P<0.05, respectively) and cholesterol-supplemented (−25%, P<0.05 and −15%, P<0.05, respectively) diets. Hepatic triglyceride concentration was lower in the defatted squid than in the control groups
in both cholesterol-free (−51%, P<0.05) and cholesterol-supplemented diets (−38%, P<0.01). The activities of cytosolic fatty acid synthase and the NADPH-generating enzymes, malic enzyme and glucose-6-phosphate
dehydrogenase, in the liver were lower in the defatted squid than in the control groups in both cholesterol-free (−21%, P<0.01, −33%, P<0.05, and −33%, P<0.01, respectively) and cholesterol-supplemented diets (−34%, P<0.05, −57%, P<0.05, and −67%, P<0.05, respectively). The activity of mitochondrial carnitine palmitoyltransferase in the liver was comparable between the
control and defatted squid groups. The activity of Mg2+-dependent phosphatidate phosphohydrolase in the liver cytosol was lower in the defatted squid (−9%, P<0.05) than in the control groups only in the cholesterol-free diet. Fecal excretion of total steroids was stimulated by the
feeding of defatted squid in both cholesterol-free (+77%, P<0.005) and cholesterol-supplemented diets (+29%, P<0.01). These results suggest that the nonlipid fraction of squid exerts a hypocholesterolemic effect by increasing the excretion
of total steroids in feces. The fraction also induces a triglyceride-lowering activity in the liver by decreasing hepatic
lipogenesis. 相似文献
52.
Riku Kawasaki Kosuke Kondo Risako Miura Keita Yamana Hinata Isozaki Risako Shimada Shogo Kawamura Hidetoshi Hirano Tomoki Nishimura Naoki Tarutani Kiyofumi Katagiri Alexandra Stubelius Shin-ichi Sawada Yoshihiro Sasaki Kazunari Akiyoshi Atsushi Ikeda 《International journal of molecular sciences》2022,23(9)
Developing photoactivatable theranostic platforms with integrated functionalities of biocompatibility, targeting, imaging contrast, and therapy is a promising approach for cancer diagnosis and therapy. Here, we report a theranostic agent based on a hybrid nanoparticle comprising fullerene nanocrystals and gold nanoparticles (FGNPs) for photoacoustic imaging and photothermal therapy. Compared to gold nanoparticles and fullerene crystals, FGNPs exhibited stronger photoacoustic signals and photothermal heating characteristics by irradiating light with an optimal wavelength. Our studies demonstrated that FGNPs could kill cancer cells due to their photothermal heating characteristics in vitro. Moreover, FGNPs that are accumulated in tumor tissue via the enhanced permeation and retention effect can visualize tumor tissue due to their photoacoustic signal in tumor xenograft model mice. The theranostic agent with FGNPs shows promise for cancer therapy. 相似文献
53.
Ichiro Imae Yuto Nakamura Kenji Komaguchi Yousuke Ooyama Joji Ohshita Yutaka Harima 《Science and Technology of Advanced Materials》2012,13(4)
We have developed a simple method of fabricating transparent conductive films with a high mechanical strength on glass and indium tin oxide substrates. It does not require a large excess of organic solvents and polymerization catalysts and can yield smooth films by spin-coating of a mixture of a commercially available aqueous dispersion of poly(3,4-ethylenedioxythiophene)-poly(4-styrene sulfonate) and a neat liquid of tetraethyl orthosilicate. Preparation conditions such as feed ratio, kinds of additives, and annealing temperature and time were optimized to give highly conductive, transparent and mechanically strong films. 相似文献
54.
Kazunari Katayama Sanshiro Kasahara Shinichiro Ishikawa Satoshi Fukada Masabumi Nishikawa 《Fusion Engineering and Design》2011,86(9-11):1702-1705
Tungsten deposits were produced by sputtering method using hydrogen isotope RF plasma, and the density and the incorporated components in the deposits were investigated. The density changed in the range from 14.2 g/cm3 to 6.1 g/cm3, and hydrogen isotope retention changed in the range from 0.25 to 0.05 as (H + D)/W by the difference of deposition conditions. Both the density and hydrogen isotope retention tended to decrease with an increase of pressure. Even though a deuterium gas was used for producing tungsten deposits, not only deuterium but also hydrogen, oxygen and water vapor were incorporated in the deposits. It is considered that the incorporation of these components originated in water vapor unintentionally existing in the vacuum chamber. 相似文献
55.
A numerical approach based on adjoint formulation of convection heat transfer is proposed to predict the change of heat transfer characteristics for arbitrary thermal and flow boundary perturbations. In order to obtain the adjoint system of the convection heat transfer problem, we formally linearize the governing equations by the perturbation method and then derive the adjoint system for the perturbation system. As a result, it is shown that the numerical solutions of the base and the adjoint problems enable us to predict the changes of heat transfer characteristics, such as the change of total heat transfer rate or the change of temperature at a specific location, when the thermal and flow boundary conditions are perturbed. An application example is presented to demonstrate the proposed method. © 2002 Wiley Periodicals, Inc. Heat Trans Asian Res, 32(1): 1–12, 2003; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/htj.10065 相似文献
56.
Shigeru Yanagi Kazunari Hasegawa Tetsushi Yuge 《Computers & Industrial Engineering》1997,33(3-4):745-748
A multi-echelon repair system is often employed for the repair of a complex device. There have been many papers on a multi-echelon repair system. Most of them, however, treat the case that i) the repair system has one central repair station(two-echelon repair model), ii)the device is a single item system. The purpose of this paper is to extend a two-echelon repair model with single item systems to a multi-echelon repair model with multi-item systems. This extension makes the repair model more realistic. Then an approximation method to obtain the steady state probabilities of the repair model is presented. This method obtains the probabilities rapidly and accurately. The reliability measure considered in this model is the system availability. It is obtained as a byproduct of the steady state probabilities. 相似文献
57.
Jun Li Zhaoshun Gao Xiaoxing Ke Yangyang Lv Huili Zhang Wei Chen Wanghao Tian Hancong Sun Sai Jiang Xianjing Zhou Tingting Zuo Liye Xiao Manling Sui Shengfu Tong Daiming Tang Bo Da Kazunari Yamaura Xuecou Tu Yun Li Yi Shi Jian Chen Biaobing Jin Lin Kang Weiwei Xu Huabing Wang Peiheng Wu 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(1)
Black phosphorus nanobelts are fabricated with a one‐step solid–liquid–solid reaction method under ambient pressure, where red phosphorus is used as the precursor instead of white phosphorus. The thickness of the as‐fabricated nanobelts ranges from micrometers to tens of nanometers as studied by scanning electron microscopy. Energy dispersive X‐ray spectroscopy and X‐ray diffraction indicate that the nanobelts have the composition and the structure of black phosphorus, transmission electron microscopy reveals a typical layered structure stacked along the b‐axis, and scanning transmission electron microscopy with energy dispersive X‐ray spectroscopy analysis demonstrates the doping of bismuth into the black phosphorus structure. The nanobelt can be directly measured in scanning tunneling microscopy in ambient conditions. 相似文献
58.
Molecular orbital calculations are applied to the Raman scattering and ESR of pyrolytic carbons on the basis of small cluster models. The E2g and A1g modes of C-C stretching vibrations of coronene, hexabenzocoronene, and circumcoronene, which belong to D6h carbon clusters, are shown to appear around the 1550 cm−1 and 1360 cm−1 bands, respectively. The unpaired electrons observed in pyrolytic carbons are attributed to the bond-alternation defects on odd-numbered carbon clusters that are more easily mobile than those of trans-polyacetylene. 相似文献
59.
Ojima D Chiba T Shima K Hiramatsu H Hosono H Hayashi K 《The Review of scientific instruments》2012,83(2):023903
An atomic oxygen (AO) source has been redesigned to coordinate with a pulsed laser deposition system and used to grow nitrogen-doped TiO(2) films by deposition of TiN and simultaneous irradiation of the substrate with AO. The AO source uses an incandescently heated thin tube of zirconia as an oxygen permeation media to generate pure AO of low kinetic energy. The emission flux is calibrated using a silver-coated quartz crystal microbalance. The thin shape of the probe and transverse emission geometry of this emission device allow the emission area to be positioned close to the substrate surface, enhancing the irradiation flux at the substrate. AO irradiation is crucial for formation of TiO(2) phases via oxidation of the deposited TiN laser plume, and is effective for decrease of the substrate temperature for crystallization of anatase phase to as low as around 200 °C. 相似文献
60.