CAE FOR THE MANUFACTURING ENGINEER: THE ROLE OF PROCESS SIMULATION IN CONCURRENT ENGINEERING

As America refocuses its attention on the factory, design and manufacturing engineers must work together closely to design the appropriate products, and matching production process in a team effort. By building off the designer's CAE tools that predict product performance, the manufacturing engineer is today able to simulate the proposed production process. Process simulations for the following manufacturing processes are available or being developed:

▪Forging, ▪Machining, ▪Injection Molding, ▪Die Casting, ▪Investment Casting, ▪Metal Forming, ▪Heat Treating, ▪Assembly Tolerancing

By utilizing the same 3-D solid model and finite element modeling tools used by the designer, coupled to powerful analysis simulation tools to predict the transient nonlinear heat transfer and plastic material flow found in many manufacturing processes, the manufacturing engineer is able to explore alternative processing plans, evaluate trade-offs and even influence the design to produce superior products.

Process simulation brings a science to support the manufacturing engineers experience for reduced lead time, lower cost, increase product quality and better understanding of the process. The next step will be to directly link the process simulation to an expert system.

This paper describes the current state of technology in the area of manufacturing process computer simulation for a number of manufacturing operations and suggests how these tools can be used “up-front” and lead to concurrent engineering.     

Biofilms and Benign Colonic Diseases

The colon has a very large surface area that is covered by a dense mucus layer. The biomass in the colon includes 500–1000 bacterial species at concentrations of ~10¹² colony-forming units per gram of feces. The intestinal epithelial cells and the commensal bacteria in the colon have a symbiotic relationship that results in nutritional support for the epithelial cells by the bacteria and maintenance of the optimal commensal bacterial population by colonic host defenses. Bacteria can form biofilms in the colon, but the exact frequency is uncertain because routine methods to undertake colonoscopy (i.e., bowel preparation) may dislodge these biofilms. Bacteria in biofilms represent a complex community that includes living and dead bacteria and an extracellular matrix composed of polysaccharides, proteins, DNA, and exogenous debris in the colon. The formation of biofilms occurs in benign colonic diseases, such as inflammatory bowel disease and irritable bowel syndrome. The development of a biofilm might serve as a marker for ongoing colonic inflammation. Alternatively, the development of biofilms could contribute to the pathogenesis of these disorders by providing sanctuaries for pathogenic bacteria and reducing the commensal bacterial population. Therapeutic approaches to patients with benign colonic diseases could include the elimination of biofilms and restoration of normal commensal bacteria populations. However, these studies will be extremely difficult unless investigators can develop noninvasive methods for measuring and identifying biofilms. These methods that might include the measurement of quorum sensing molecules, measurement of bile acids, and identification of bacteria uniquely associated with biofilms in the colon.     

磷、硅阻燃协同效应的研究及应用

对磷系阻燃剂、硅系阻燃剂及其协同阻燃体系的阻燃机理进行深入研究,详细叙述了磷硅协同阻燃体系在棉织物中的应用情况,并对其发展前景进行了展望.     

Does the model matter? The relationship between science-practice emphasis in clinical psychology programs and the internship match.

[Correction Notice: An erratum for this article was reported in Vol 1(4) of Training and Education in Professional Psychology (see record 2007-18975-009). The biography for the third author was incorrect. It should read as follows: GREGORY KEILIN is an Assistant Director at the Counseling and Mental Health Center at the University of Texas at Austin and a former Chair of APPIC. He received his doctorate in Counseling Psychology from Colorado State University. His current research interests include supply and demand issues in professional psychology.] Academic training programs in clinical psychology vary in the emphasis that they place on science and practice, and this paper examines whether these differential emphases are linked to distinctive internship outcomes. In a study of 2,130 internship applicants from clinical psychology programs, differences were noted among practice-oriented programs, balanced science-practice programs, and science-oriented programs. Against a backdrop of some similarities, a differential emphasis on science and practice within academic training programs was related to significantly different internship match rates, as well as to successful matching in qualitatively different internship settings. Results provided qualified support for future work that might further address the relationship between academic training programs and outcomes in the field of clinical psychology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dyadic spatial resolution reduction transcoding for H.264/AVC

In this paper, we examine spatial resolution downscaling transcoding for H.264/AVC video coding. A number of advanced coding tools limit the applicability of techniques, which were developed for previous video coding standards. We present a spatial resolution reduction transcoding architecture for H.264/AVC, which extends open-loop transcoding with a low-complexity compensation technique in the reduced-resolution domain. The proposed architecture tackles the problems in H.264/AVC and avoids visual artifacts in the transcoded sequence, while keeping complexity significantly lower than more traditional cascaded decoder–encoder architectures. The refinement step of the proposed architecture can be used to further improve rate-distortion performance, at the cost of additional complexity. In this way, a dynamic-complexity transcoder is rendered possible. We present a thorough investigation of the problems related to motion and residual data mapping, leading to a transcoding solution resulting in fully compliant reduced-size H.264/AVC bitstreams.     

The MAOA rs979605 Genetic Polymorphism Is Differentially Associated with Clinical Improvement Following Antidepressant Treatment between Male and Female Depressed Patients

Major depressive disorder (MDD) is the leading cause of disability worldwide. Treatment with antidepressant drugs (ATD), which target monoamine neurotransmitters including serotonin (5HT), are only modestly effective. Monoamine oxidase (MAO) metabolizes 5HT to 5-hydroxy indoleacetic acid (5HIAA). Genetic variants in the X-chromosome-linked MAO-encoding genes, MAOA and MAOB, have been associated with clinical improvement following ATD treatment in depressed patients. Our aim was to analyze the association of MAOA and MAOB genetic variants with (1) clinical improvement and (2) the plasma 5HIAA/5HT ratio in 6-month ATD-treated depressed individuals. Clinical (n = 378) and metabolite (n = 148) data were obtained at baseline and up to 6 months after beginning ATD treatment (M6) in patients of METADAP. Mixed-effects models were used to assess the association of variants with the Hamilton Depression Rating Scale (HDRS) score, response and remission rates, and the plasma 5HIAA/5HT ratio. Variant × sex interactions and dominance terms were included to control for X-chromosome-linked factors. The MAOA rs979605 and MAOB rs1799836 polymorphisms were analyzed. The sex × rs979605 interaction was significantly associated with the HDRS score (p = 0.012). At M6, A allele-carrying males had a lower HDRS score (n = 24, 10.9 ± 1.61) compared to AA homozygous females (n = 14, 18.1 ± 1.87; p = 0.0067). The rs1799836 polymorphism was significantly associated with the plasma 5HIAA/5HT ratio (p = 0.018). Overall, CC/C females/males had a lower ratio (n = 44, 2.18 ± 0.28) compared to TT/T females/males (n = 60, 2.79 ± 0.27; p = 0.047). The MAOA rs979605 polymorphism, associated with the HDRS score in a sex-dependent manner, could be a useful biomarker for the response to ATD treatment.     

环保型纤维纺织品的生态性及染整加工(下)

上期提要:综述了罗布麻纤维、天然彩色棉花、甲壳素纤维、Lyocell纤维、聚乳酸纤维、大豆蛋白纤维等环保纤维纺织品的生态性和染整加工要点.