Three‐phase immittance converter

The immittance converter has an input impedance that is proportional to the admittance of a load connected across its output terminals. In this converter, the output current is proportional to the input voltage and the input current is proportional to the output voltage. Consequently, a constant‐voltage source is converted into a constant‐current source and a constant‐current source into a constant‐voltage source. The immittance converters consisting of only passive elements (inductors L and capacitors C) are suitable for use in the high‐frequency links in power electronics applications. Previously, we proposed several types of immittance converters and some applications to power electronics equipment. In this paper, we propose a new three‐phase immittance converter consisting of three L and C elements each to obtain an alternating current source from a three‐phase voltage source without control. This paper presents a configuration of the new three‐phase immittance converter that operates in either anti‐phase or in‐phase modes between the input voltage and the output voltage, and its voltage–current conversion characteristics and efficiency characteristics. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 145(1): 52– 58, 2003; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.10169     

Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12

cDNAs encoding the human homolog of BAG1, a Bcl-2-binding protein with anti-apoptotic function, were cloned. DNA sequence analysis of human BAG1 cDNAs predicts a protein with an additional 55 amino acids at its NH2-terminus compared to the mouse protein. Immunoblot assays using monoclonal antibodies raised against bacterially produced h-BAG1 protein confirmed the larger size of the human protein (approximately 34 kDa) compared to mouse. PCR analysis of DNA from human x rodent somatic cell hybrids using human BAG1-specific primers localized the gene to human chromosome 9. Cosmid clones of h-BAG1 were obtained and used for fluorescence in situ hybridization analysis of normal metaphase chromosomes, thus localizing h-BAG1 to 9p12, a region associated with hereditary disorders that may involve developmental dysregulation of programmed cell death.     

In vivo determination of replication origins of human mitochondrial DNA by ligation-mediated polymerase chain reaction

A large part of replication is aborted in human mitochondria, the result being a D-loop. As few attempts have been made to distinguish free 5' ends of true replicate from those of abortive ones, we examined the 5' ends of true replicate of human mitochondrial DNA at one nucleotide resolution in vivo by making use of ligation-mediated polymerase chain reaction. The distribution and relative amounts of origins of the true replicate are exactly the same as those of total newly synthesized heavy strands, which means that the abortion of replication is independent of 5' ends. Treatment of DNA with RNase H frees 5' ends on both heavy and light strands. This is the first in vivo evidence for covalently attached primer RNA to nascent strand in human mitochondrial DNA.     

Hybrid‐type immittance converter

The immittance converter has an input impedance that is proportional to the admittance of a load connected across output terminals. Therefore, in this converter, the output current is proportional to the input voltage and the input current is proportional to the output voltage. Consequently, it converts a constant‐voltage source into a constant‐current source and a constant‐current source into a constant‐voltage source. It is well know that the quarter‐wavelength transmission line shows immittance conversion characteristics. However, it has a very long line length for the switching frequency of converters and is not suitable for power electronics application. Thus, we proposed five types of immittance converters that consist of lumped elements L and C and showed improved immittance conversion characteristics at a resonant frequency. The output characteristics and efficiency characteristics of an immittance converter are the most important parameter when it is used in practical applications in a high‐frequency link. In this paper, we show voltage–current transformation characteristics, current–voltage transformation characteristics, and efficiency characteristics of a hybrid‐type immittance converter which consist of L and C elements with losses. The excellent characteristics were confirmed analytically and experimentally. © 2001 Scripta Technica, Electr Eng Jpn, 138(3): 80–86, 2002     

Cytologic and genetic study of polyomavirus-infected or polyomavirus-activated cells in human urine

The treatment of small-cell lung carcinoma (SCLC) requires the careful combination of chemotherapy and radiation therapy. To understand the factors involved in the outcome of these patients, the authors undertook a study of patients treated for limited stage SCLC. The charts of 194 consecutive patients treated at our facilities between 1986 and 1994 were reviewed. All patients underwent thoracic radiation therapy (TRT), 50% received prophylactic cranial irradiation (PCI), and all but one received chemotherapy. The probability of survival at 5 years was 14%, and the disease-free survival (DFS) was 17%. Patients receiving a combination of platinum and etoposide (PE) and Cytoxan (Bristol-Myers, Evansville, IN, U.S.A.), Adriamycin (Adria Laboratories, Dublin, OH, U.S.A.), and Vincristine (Eli Lilly, Indianapolis, IN, U.S.A.) (CAV) experienced a DFS at 3 years of 31%, versus 14% for CAV only and 18% for PE only (p = 0.004). In a multivariate survival analysis, only PCI (p = 0.001), having received PE and CAV (p = 0.01), and response to treatment (p = 0.001) were significant. Radiation dose and field size did not influence outcome. The combination of PE and CAV chemotherapy produced the best results in our series. Unanswered questions regarding the optimal TRT dose, field size, and timing of TRT await the results of ongoing randomized trials.     

Photocytotoxicity of water-soluble fullerene derivatives

New water-soluble fullerene carboxylic acids (1 and 2) derived from C60 and C70 fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50 microM, while pheophorbide a showed significant photocytotoxicity at 0.5 microM. Therefore, fullerene derivatives derived from C60 and C70 would not be practical agents for photodynamic therapy.     

DFT studies of interaction of Ir cluster with O2, CO and NO

Hybrid DFT calculations have been carried out for IrCO, IrNO, IrO₂, Ir₁₃CO, Ir₁₃NO, and Ir₁₃O₂ clusters in order to investigate the electronic state and the catalytic activity of Ir catalyst. The results of Ir model clusters show that the surface atoms of the Ir₁₃ cluster have small negative charges and the clusters have strong interactions with adsorbates.     

Value of MR cholangiopancreatography in evaluating choledochal cysts

OBJECTIVE: The aim of this retrospective study was to clarify whether MR cholangiopancreatography (MRCP) is a suitable replacement for ERCP in evaluation of the choledochal cyst. MATERIALS AND METHODS: Sixteen patients (six adult and 10 pediatric) with choledochal cysts underwent MRCP using a half-Fourier acquisition single-shot turbo spin-echo sequence. Extent of the cyst, defects within the biliary tree, and presence or absence of the anomalous junction of the pancreaticobiliary duct were evaluated. Findings were compared with those of ERCP. RESULTS: MRCP better defined the proximal biliary tree than did ERCP in two patients. Defects within the biliary tree were diagnosed correctly on MRCP in eight patients; however, two defects within the distal common bile duct were missed in pediatric patients. The presence of the anomalous junction of the pancreaticobiliary duct was revealed accurately by MRCP in all adult patients but was revealed accurately in only four of the 10 pediatric patients. CONCLUSION: MRCP appears to offer diagnostic information that is equivalent to that of ERCP for assessment of choledochal cysts in adults. In pediatric patients, MRCP should not replace ERCP; however, MRCP can play an important role as a noninvasive examination and should be considered a first-choice imaging technique for evaluation of choledochal cysts.