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排序方式: 共有1449条查询结果,搜索用时 328 毫秒
41.
Hideaki Adachi Toshifumi Satoh Masahiro Sakai Koichi Mizuno Kentaro Setsune 《Journal of Superconductivity》1994,7(4):737-741
Epitaxial multilayer thin films of infinite-layer (Sr, Ca)CuO2 and perovskite (Sr, Ca)RuO3 have been prepared on (100) SrTiO3 substrates by multitarget rf magnetron sputtering. X-ray diffraction analyses revealed that the multilayer structure of (Sr, Ca)CuO3/(Sr, Ca)RuO3 was successfully fabricated with a minimum layer thickness of 20 Å. Transmission electron microscopy measurements of the multilayers indicated that there was no dislocation which normally exists in single-layer films with an infinite-layer structure. Resistivities of multilayer films at room temperature ranged from 1 to 10 m cm and showed semiconductor-like dependence against the temperature. 相似文献
42.
The coenzyme specificity of 3isopropylmalate dehydrogenasefrom an extreme thermophile, Thermus thermophilus HB8, was changedfrom NAD to NADP by sitedirected mutagenesis Based onsequence comparison of 3isopropylmalate dehydrogenasesfrom various organisms with NAD and NADPdependentisocitrate dehydrogenases, Ser226, Ser253 and De279 of 3isopropylmalatedehydrogenase were suggested as determining the coenzymespecificity. These residues were replaced with the correspondingresidues of NADPdependent isocitrate dehydrogenases;Arg, Gly and Tyr respectively. The singlemutated enzymes,S226R and I279Y, enhanced the activities towards NADP 10and 3fold respectively, whereas S253G reduced the activity.Among the multiplemutated enzymes, the doublemutatedS226R/I279Y increased the catalytic efficiency against NADP( fold) and shifted the specificity for NAD towards NADP mostsignificantly ( 173fold). 相似文献
43.
S Kawai F Imazeki O Yokosuka M Ohto S Shiina N Kato M Omata 《Canadian Metallurgical Quarterly》1995,22(1):112-117
Analysis of X-chromosome inactivation patterns in women has been used to assess the clonality of various tumors. In this report, we analyzed 27 liver tumors in women, including 18 samples obtained by the performance of ultrasonically guided thin-needle biopsies. By analysis of the heterogeneity of phosphoglycerate kinase gene, 11 of 27 (41%) cases were found to be heterozygous at the gene. Of these informative 11 cases with liver tumors, 7 cases were "large" tumors (> 25 mm in diameter) and 4 cases were "small" tumors (< 25 mm in diameter). All 7 large tumors showed monoclonal patterns by the phosphoglycerate kinase gene analysis. Of the 4 small tumors, 2 showed monoclonal, and 2 showed polyclonal patterns. The 2 with monoclonal patterns were pathologically diagnosed as hepatocellular carcinoma despite their small sizes (20 mm and 23 mm). Of the two with polyclonal patterns, the smallest one (15 mm) was diagnosed as benign adenomatous hyperplasia, and the other as hepatocellular carcinoma heavily infiltrated by lymphocytes. These data suggest that analysis of the methylation pattern of the phosphoglycerate kinase gene may be helpful on rare occasions in elucidating the nature of liver tumors but must in fact be used in conjunction with histological appearances to avoid errors secondary to inflammatory infiltrates. 相似文献
44.
Tamada Tsutomu Ueda Yu Kido Ayumu Yoneyama Masami Takeuchi Mitsuru Sanai Hiroyasu Ono Kentaro Yamamoto Akira Sone Teruki 《Magma (New York, N.Y.)》2022,35(4):549-556
Magnetic Resonance Materials in Physics, Biology and Medicine - Image quality (IQ) of diffusion-weighted imaging (DWI) with single-shot echo-planar imaging (ssEPI) suffers from low signal-to-noise... 相似文献
45.
46.
Specimen-size effect and notch-size effect on the tensile strength of woven fabric carbon/epoxy laminates are evaluated and modeled. For two different layups of [(0/90)12] and [(±45)2/(0/90)5]S, respectively, static tension tests were performed on two-dimensional geometrically similar unnotched and double-edge notched specimens scaled to three different sizes. Experimental results demonstrate that the notched strength of the woven CFRP laminates depend on the size of specimen as well as the size of notch. The ratio of notched strength to unnotched strength decreases as the length of notch increases, regardless of the size of specimen. For a given size of notch, the notch strength ratio becomes larger with decreasing size of specimen. A notch-size effect law is derived by means of the Neuber interpolation method. A specimen-size effect is embedded into the notch sensitivity parameter involved by the notch-size effect law to establish a size effect law that can cope with these two kinds of size effect. The engineering size effect law proposed can adequately describe the specimen-size effect as well as notch-size effect on the tensile strength of the woven CFRP laminates. It is also demonstrated that the size effect law allows determining the size independent fracture toughness on the basis of notched strengths of small specimens that fail in a quasi-brittle manner. 相似文献
47.
BACKGROUND: The study was carried out to evaluate the correlation between blood-retinal barrier (BRB) permeability and the progression of diabetic retinopathy (DR), defined by development of "need for photocoagulation", over a 7-year period by means of vitreous fluorometry (VF). METHODS: Forty type 2 diabetic patients with minimal or no retinopathy, aged 40-65 years (mean 53.9 + 7.3 years), were followed up prospectively for 7 years. Investigations including standard ophthalmological examination, fundus photography, fluorescein angiography and VF were performed at entry and 1, 4, 5 and 7 years later. Only one eye per patient was included in the study. Need for photocoagulation was based on Early Treatment Diabetic Retinopathy Study protocols and decided by the attending ophthalmologist. RESULTS: After 7 years of follow-up a total of 22 of the 40 eyes had received photocoagulation. The eyes that needed photocoagulation were those that had higher VF values at the entry of the study and showed higher rates of deterioration (initial values 5.1 + 1.9 vs 2.8 + 1.5 x 10(-6) min-1, P < 0.001; annual increase in leakage for the first year, 1.5 + 0.8 vs 0.5 + 1.0 x 10(-6) min-1, P < 0.001,). The eyes that did not need photocoagulation during the 7 years of follow-up showed stable VF readings (-0.1 + 1.2 x 10(-6) min-1, difference between initial values and 7 years later). CONCLUSIONS: Abnormally high VF values and their rapid increase over time are good indicators of progression and worsening of the retinopathy in diabetes type 2. 相似文献
48.
Kazuto Okazaki Tatsuya Ogiwara Dongshin Yang Kentaro Sakata Ken Saito Yoshifumi Sekine Fumio Uchikoba 《Artificial Life and Robotics》2011,16(2):229-233
This article presents the micro-electro-mechanical systems (MEMS) microrobot which demonstrates locomotion controlled by hardware
neural networks (HNN). The size of the microrobot fabricated by the MEMS technology is 4 × 4 × 3.5 mm. The frame of the robot
is made of silicon wafer, and it is equipped with a rotary-type actuator, a link mechanism, and six legs. The rotary-type
actuator generates rotational movement by applying an electrical current to artificial muscle wires. The locomotion of the
microrobot is obtained by the rotation of the rotary-type actuator. As in a living organism, the HNN realized robot control
without using any software programs, A/D converters, or additional driving circuits. A central pattern generator (CPG) model
was implemented as an HNN system to emulate the locomotion pattern. The MEMS microrobot emulated the locomotion method and
the neural networks of an insect with the rotary-type actuator, the link mechanism, and the HNN. The microrobot performed
forward and backward locomotion, and also changed direction by inputting an external trigger pulse. The locomotion speed was
0.325 mm/s and the step width was 1.3 mm. 相似文献
49.
Kikuta K Tochigi N Saito S Shimoda T Morioka H Toyama Y Hosono A Suehara Y Beppu Y Kawai A Hirohashi S Kondo T 《Proteomics. Clinical applications》2010,4(5):560-567
Purpose : We aimed to identify novel chemotherapy responsiveness biomarkers for osteosarcoma (OS) by investigating the global protein expression profile of 12 biopsy samples from OS patients. Experimental design : Six patients were classified as good responders and six as poor responders, according to the Huvos grading system. The protein expression profiles obtained by 2‐D DIGE consisted of 2250 protein spots. Results : Among them, we identified 55 protein spots whose intensity was significantly different (Bonferroni adjusted p‐value<0.01) between the two patient groups. Mass spectrometric protein identification demonstrated that the 55 spots corresponded to 38 distinct gene products including peroxiredoxin 2 (PRDX 2). Use of a specific antibody against PRDX 2 confirmed the differential expression of PRDX 2 between good and poor responders, while PRDX 2 levels as measured by Western blotting correlated highly with their corresponding 2‐D DIGE values. The predictive value of PRDX 2 expression was further confirmed by examining an additional four OS cases using Western blotting. Conclusions and clinical relevance : These results establish PRDX 2 as a candidate for chemotherapy responsiveness marker in OS. Measuring PRDX 2 in biopsy samples before treatment may contribute to more effective management of OS. 相似文献
50.
Takuro Tomita Ayahito Uetake Tsutomu Asahina Kentaro Kayanuma Akihiro Murayama Yasuo Oka 《Journal of Superconductivity and Novel Magnetism》2005,18(3):405-410
Spin injection processes in the double quantum dots of ZnSe-based diluted magnetic semiconductors are discussed. Double quantum
dots are fabricated from ZnSe-based double quantum wells by electron beam lithography and wet etching. In these samples, the
photo-excited carriers in the magnetic dots are injected into the non-magnetic dots. The circular polarization degrees of
photoluminescence from the non-magnetic dots are measured by micro-photoluminescence measurement system under the magnetic
field up to 5 T. The maximum spin polarization degrees of injected carriers determined from our experiment are 10% for double
quantum wells and 15% for double quantum dots. The spin injection efficiency was estimated both from the observed circular
polarization degree and the diffusion length of carriers. We concluded that the spin injection efficiency is increased in
the double quantum dots. 相似文献