Increasing attendance at colorectal cancer screening: Testing the efficacy of a mailed, psychoeducational intervention in a community sample of older adults.

This article describes a trial of a psychoeducational intervention designed to modify negative attitudes toward flexible sigmoidoscopy screening and thereby increase screening attendance. The intervention materials addressed the multiple barriers shown to be associated with participation in earlier studies. Adults ages 55-64 (N=2,966), in a "harder-to-reach" group were randomized either to receive an intervention brochure or to a standard invitation group. Attitudes and expectations were assessed by questionnaire, and attendance at the clinic was recorded. Compared with controls, the intervention group had less negative attitudes, anticipated a more positive experience, and had a 3.6% higher level of attendance. These results indicate that psychoeducational interventions can provide an effective means of modifying attitudes and increasing rates of screening attendance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neuronopathic forms of Gaucher's disease

Neuronopathic Gaucher patients may have a wide variety of clinical manifestations and natural history, and can present with a range of degrees of severity of systemic disease and neurological deficit. The brain pathology of these patients has been well described, but the mechanism by which glucocerebrosidase deficiency leads to neuronal dysfunction is not yet understood. The almost 20 different mutations of the glucocerebrosidase gene that have been described in Type 2 and 3 Gaucher patients poorly predict the phenotype of individual patients. Enzyme replacement therapy (ERT), often at high doses, has been shown to reverse most of the systemic manifestations of this disease, but can rarely reverse the neurological deficits. Therefore, other forms of treatment, such as gene therapy or a more efficient and direct enzyme delivery to neurons, are being devised.     

A Natural Algacide from Soft Coral Sinularia flexibilis (Coelenterata, Octocorallia, Alcyonacea)

A crude lipophilic extract and specific pure metabolites of the soft coral Sinularia flexibilis have been examined for algacidal properties both in laboratory and field experiments. Laboratory algal bioassays, in which cultures of the common fouling alga Ceramium codii were incubated with six different diterpenes isolated from S. flexibilisrevealed that 11-episinulariolide exhibits strong algacidal properties. Field experiments carried out with treated settlement tiles confirmed the laboratory findings and provided evidence for the algacidal properties of 11-episinulariolide against several other common reef algae. Sinulariolide, which had previously been reported to inhibit the growth of unicellular algae, was approximately one third as effective as its stereoisomer 11-episinulariolide in the laboratory growth inhibition bioassay and showed no significant algacidal properties at the concentrations used in the field experiments.     

Synthesis of novel tricalcium phosphate-bioactive glass composite and functionalization with rhBMP-2

A functionalization is required for calcium phosphate-based bone substitute materials to achieve an entire bone remodeling. In this study it was hypothesized that a tailored composite of tricalcium phosphate and a bioactive glass can be loaded sufficiently with rhBMP-2 for functionalization. A composite of 40 wt% tricalcium phosphate and 60 wt% bioactive glass resulted in two crystalline phases, wollastonite and rhenanite after sintering. SEM analysis of the composite’s surface revealed a spongious bone-like morphology after treatment with different acids. RhBMP-2 was immobilized non-covalently by treating with chrome sulfuric acid (CSA) and 3-aminopropyltriethoxysilane (APS) and covalently by treating with CSA/APS, and additionally with 1,1′-carbonyldiimidazole. It was proved that samples containing non-covalently immobilized rhBMP-2 on the surface exhibit significant biological activity in contrast to the samples with covalently bound protein on the surface. We conclude that a tailored composite of tricalcium phosphate and bioactive glass can be loaded sufficiently with BMP-2.     

Butter, Speisefette und ?le

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Milch und K?se

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