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排序方式: 共有241条查询结果,搜索用时 31 毫秒
101.
Nakajima N Nozaki N Ishihara K Ishikawa A Tsuji H 《Journal of Bioscience and Bioengineering》2005,100(6):685-687
To produce a tempeh-like functional food containing a high level of isoflavone with a high absorptivity, we analyzed changes in the composition of isoflavone during tempeh fermentation and the difference in isoflavone content depending on the soybean variety and particular tissue. By adding soybean germ (hypocotyl) that contained a large amount of isoflavone, we prepared a new isoflavone-enriched tempeh in the form of a granular fermented soybean-based food, which can serve as a nutritious supplement for the elderly. 相似文献
102.
Masafumi Tasaki Hiroko Yamamoto Taiyo Yoshioka Makoto Hanesaka Tran Hai Ninh Kohji Tashiro Hye Jin Jeon Kwang Bok Choi Hak Seung Jeong Hyun Hoon Song Moon Hor Ree 《Polymer》2014
Relationship between the chain conformation in the crystal lattice and the ultimate Young's modulus has been discussed on the basis of the crystal structural information revealed by the X-ray diffraction analysis for a series of arylate polyesters with long methylene segments (–[–COC6H4CO–O(CH2)mO–]n–). The X-ray structural analysis revealed that the molecular chains take the all-trans-zigzag conformations for all of the even-numbered polyesters and their model compounds as well as the odd-numbered polyesters with the methylene segmental length longer than (CH2)14. These chain conformations have been correlated well to the ultimate Young's modulus along the chain axis or the crystallite modulus Ec, which has been estimated experimentally by the X-ray diffraction method under a constant stress and also predicted theoretically using the X-ray-analyzed crystal structures on the basis of the molecular mechanics method. The Ec was found to show the minimum at around m = 4–6 and increased gradually with an increment of m and approached the crystallite modulus of polyethylene, 235 GPa (X-ray value) ∼ 316 GPa (calculate) at an infinite m value. This behavior of Ec as a function of the number of methylene segmental units m was reasonably interpreted by developing the theoretical equation of Ec for a simplified zigzag chain model composed of a repetition of two linear rods representing the benzene–ester and methylene segmental parts respectively. These findings may promise that the mechanical property of arylate polyester can be controlled by adjusting the methylene segmental length m. 相似文献
103.
Kohji Tashiro Kohji Takano Masamichi Kobayashi Yozo Chatani Hiroyuki Tadokoro 《Polymer》1983,24(2):199-204
A phase transition at a temperature immediately below the melting point of poly(vinylidene fluoride) form I has been found by means of differential scanning calorimetry (d.s.c.) and infra-red (i.r.) vibrational spectroscopy. An endothermic d.s.c. shoulder has been observed at a temperature about 10°C below the melting point, in the vicinity of which the i.r. crystalline trans bands decrease in intensity steeply and the crystalline gauche bands increase in intensity, indicating the conformational change from all-trans to T3GT3G type. These observations have been found to be detectable more clearly for samples subjected to the poling treatment under a d.c. high voltage. The transition shows the characteristic behaviour essentially identical to those observed for ferroelectric copolymers of vinylidene fluoride and trifluoroethylene, except for the irreversibility of the structural change, suggesting that the phase transformation revealed here may be a ferroelectric-to-paraelectric phase transition of polar form I crystal and the the Curie point may be about 172°C. It is consistent with Micheron's measurement of the temperature dependence of the dielectric constant. Other structural changes in the form I sample occurring in the temperature range from 20° to 170°C have also been discussed based on the i.r. spectral measurements. 相似文献
104.
Jing Xu Ichiro Kawahata Hisanao Izumi Kohji Fukunaga 《International journal of molecular sciences》2021,22(12)
Lewy bodies are pathological characteristics of Lewy body dementia (LBD) and are composed of α-synuclein (α-Syn), which is mostly degraded via the ubiquitin–proteasome system. More importantly, 26S proteasomal activity decreases in the brain of LBD patients. We recently introduced a T-type calcium channel enhancer SAK3 (ethyl-8-methyl-2,4-dioxo-2-(piperidin-1-yl)- 2H-spiro[cyclopentane-1,3-imidazo [1,2-a]pyridin]-2-ene-3-carboxylate) for Alzheimer’s disease therapeutics. SAK3 enhanced the proteasome activity via CaMKII activation in amyloid precursor protein knock-in mice, promoting the degradation of amyloid-β plaques to improve cognition. At this point, we addressed whether SAK3 promotes the degradation of misfolded α-Syn and the aggregates in α-Syn preformed fibril (PFF)-injected mice. The mice were injected with α-Syn PFF in the dorsal striatum, and SAK3 (0.5 or 1.0 mg/kg) was administered orally for three months, either immediately or during the last month after injection. SAK3 significantly inhibited the accumulation of fibrilized phosphorylated-α-Syn in the substantia nigra. Accordingly, SAK3 significantly recovered mesencephalic dopamine neurons from cell death. Decreased α-Syn accumulation was closely associated with increased proteasome activity. Elevated CaMKII/Rpt-6 signaling possibly mediates the enhanced proteasome activity after SAK3 administration in the cortex and hippocampus. CaMKII/Rpt-6 activation also accounted for improved memory and cognition in α-Syn PFF-injected mice. These findings indicate that CaMKII/Rpt-6-dependent proteasomal activation by SAK3 recovers from α-Syn pathology in LBD. 相似文献
105.
An elastic polymer with hydroxymethyl side chains, which contains some crosslinked structure, has been prepared by treating its prepolymer with maleic anhydride and styrene in the presence of an initiator. Its mechanical properties were varied largely by the molar ratio of the hydroxyl group:maleic anhydride:styrene. A typical example of the polymer showed elongation 69%, tensile strength 0.85 kgf/mm2, and Young's modulus 9.4 kgf/mm2. Some other modifications are also examined. 相似文献
106.
Satoshi Murata Haruhisa Kurokawa Kohji Tomita Shigeru Kokaji 《Artificial Life and Robotics》1997,1(3):111-115
A novel design method for a mechanical system is proposed and a prototype model is constructed. Conventional machine systems
are composed of various parts which are all passive. In this new scheme, mechanical systems are made with only one kind of
active and intelligent unit. The prototype of this kind of unit is called a “fractum”, which has actuators, sensors, and information
processing functions. In the system, there is no supervising unit nor central controller. The units are all the same and have
an equivalent capacity, so that any of them can replace any other unit. Knowledge about the whole system is embedded in every
unit, and this enables a group of these units to organize the whole system by themselves and to repair it by themselves. The
algorithm for this self-organization and self-repair is designed and tested by computer simulations.
This work was presented, in part, at the International Symposium on Artificial Life and robotics, Oita, Japan, February 18–20,
1996 相似文献
107.
108.
Bioelectronic sniffer device for trimethylamine vapor using flavin containing monooxygenase 总被引:1,自引:0,他引:1
A bioelectronic sniffer device for trimethylamine (TMA) in the gas phase "fish-odor substance" was constructed using a flavin-containing monooxygenase 3 (FMO3, one of xeno-biotic metabolizing enzymes) and a reaction unit with both gas and liquid cells separated by a porous poly(tetrafluoroethylene) diaphragm membrane (pore size: 30-60 /spl mu/m, thickness: 0.20 mm). A substrate regeneration cycle was applied to the FMO3 immobilized device in order to amplify the output signal by coupling the monooxygenase with a reducing reagent system of ascorbic acid (ASA) in phosphate buffer. The sniffer device with 10.0 mmol/l AsA could be used to measure TMA vapor from 0.52 to 105 ppm; this covers the maximum permissible concentration in the work place (5.0 ppm of time weighted average concentration) and the sensing level-5 of smell in humans (3.0 ppm). Since the application of the substrate regeneration cycle was possibly successful, it improved the sensitivity of the FMO3 immobilized device. The sniffer device possessed high selectivity for TMA being attributable to the FMO3 substrate specificity, continuous measurability, and good reproducibility in the repeatedly measurements (coefficient of variation = 2.41%, n=10). 相似文献
109.
Standard Penetration Test-Based Probabilistic and Deterministic Assessment of Seismic Soil Liquefaction Potential 总被引:12,自引:0,他引:12
K. Onder Cetin Raymond B. Seed Armen Der Kiureghian Kohji Tokimatsu Leslie F. Harder Jr. Robert E. Kayen Robert E. S. Moss 《Canadian Metallurgical Quarterly》2004,130(12):1314-1340
This paper presents new correlations for assessment of the likelihood of initiation (or “triggering”) of soil liquefaction. These new correlations eliminate several sources of bias intrinsic to previous, similar correlations, and provide greatly reduced overall uncertainty and variance. Key elements in the development of these new correlations are (1) accumulation of a significantly expanded database of field performance case histories; (2) use of improved knowledge and understanding of factors affecting interpretation of standard penetration test data; (3) incorporation of improved understanding of factors affecting site-specific earthquake ground motions (including directivity effects, site-specific response, etc.); (4) use of improved methods for assessment of in situ cyclic shear stress ratio; (5) screening of field data case histories on a quality/uncertainty basis; and (6) use of high-order probabilistic tools (Bayesian updating). The resulting relationships not only provide greatly reduced uncertainty, they also help to resolve a number of corollary issues that have long been difficult and controversial including: (1) magnitude-correlated duration weighting factors, (2) adjustments for fines content, and (3) corrections for overburden stress. 相似文献
110.
Tomohito Hamazaki Masaharu Urakaze Saburo Yano Yasuji Soda Akira Miyamoto Kohji Kubota Fumio Ibuki 《Lipids》1987,22(12):1031-1034
An injectable emulsion of docosahexaenoic acid (DHA) was prepared. One hundred ml of the emulsion contained 3 g of 93%-pure
1,2,3-tridocosahexaenoylglycerol (DHA-TG), 1.2 g of 93%-pure 2-docosahexaenoyl-phosphatidylcholine as an emulsifier and 2.5
g of glycerol. Thirty ml of the emulsion of DHA-TG was injected into three rabbits on days 1 and 4 of the study. Blood was
taken on day 0, on day 4 just before the second injection and on day 7. The percentage of DHA in the total phospholipid fraction
of platelets increased from 0.46% (day 0) to 1.88% (day 4, p<0.05) and 3.66% (day 7; p<0.02 vs day 0). The percentage of eicosapentaenoic
acid (EPA) increased from 0.46% (day 0) to 1.03% (day 4, p<0.02) and 1.63% (day 7: p<0.05 vs day 0). The percentage of arachidonic
acid (AA) decreased from 9.45% (day 0) to 4.31% (day 4, p<0.05) and 6.68% (day 7; p<0.02 vs day 0). The percentage of DHA
in the total phospholipid fraction of erythrocyte membranes increased from 0.23% (day 0) to 0.91% (day 4, p<0.05) and 1.52%
(day 7; p<0.005 vs day 0); that of EPA increased from 0.21% (day 0) to 0.34% (day 4, p<0.005%) and 0.52% (day 7, p<0.01 vs
day 0); that of AA was unchanged. Blood lipids were the same before and after the two injections of the emulsion, except that
free fatty acids decreased markedly from 0.32 to 0.06 mEq/1 (p<0.02). On day 8, free AA (2 mg/kg) was injected into ear veins
of the three treated rabbits and of four control rabbits (not treated with DHA-TG). All the control rabbits died a few minutes
after the AA injection, but none of the DHA-treated rabbits died after AA injection (p<0.01). An emulsion of DHA-TG may be
useful for patients having immediate risk of thrombosis or for those who need DHA but cannot take it orally. 相似文献