轨道交通站点TOD合理区范围探讨——以广州地铁二号线江南西站为例

通过问卷调查分析,将TOO合理区范围的研究上升到设施使用层面,即按照交通设施利用率和交通影响范围的方法来确定轨道交通车站合理区阀值.该方法具有简便、实用,结果更符合实际等特点,适用于任何孤立的快速公交站点的合理区范围的确定,但不适用于涉及两个或两个以上车站的研究.     

鼎湖山自然保护区胡椒属植物生物学特性研究

研究了鼎湖山自然保护区分布的8种胡椒属植物的外部形态，根尖和茎法细胞的染色体数目，花粉外部形态和繁殖保护方法，并根据研究结果对该保护区内关于本属植物存在的问题和应对策略作了初步探讨。     

Antibody Therapies Targeting Complex Membrane Proteins

In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupled receptors (GPCRs) dominate, followed by ion channels, transporters, and—to a lesser extent—membrane-bound enzymes. However, various challenges put such membrane proteins among key groups of underutilized opportunities for the application of therapeutic antibodies. Antibodies hold the promise of exquisite specificity, as they are able to target even specific conformations of a particular membrane protein, as well as adaptability through engineering into various antibody formats. However, the ease of raising and isolating specific, effective antibodies targeting membrane proteins depends on many factors. In particular, the generation of specific antibodies is easier when targeting larger, simpler, extracellular domains with greater uniqueness of amino acid sequence. The rareness of such ideal conditions is illustrated by the limited number of approved biologics for targeting GPCRs and other complex membrane proteins. Challenges in developing antibodies to complex membrane proteins such as GPCRs, ion channels, transporters, and membrane-bound enzymes can be addressed by the design of the antigen, antibody-generation strategies, lead optimization technologies, and antibody modalities. A better understanding of the membrane proteins being targeted would facilitate mechanism-based drug discovery. This review describes the advantages and challenges of targeting complex membrane proteins with antibodies and discusses the preparation of membrane protein antigens and antibody generation, illustrated by select examples of success.     

金属切削液在轴承加工中的应用

着重介绍金属切削液的分类、功能及其在轴承加工中的选用。在轴承加工中,一般有车削、铣削、钻削、铰削和磨削等多种加工工艺,其中磨削加工是一道非常重要的精密加工工序,如内圆磨削、外圆磨削、平面磨削和沟槽磨削等。轴承加工中使用的水基切削液不仅要具有冷却作用,还要有润滑、清洗和防锈的功能。重点介绍金属切削液的主要功能及其在轴承加工中的应用。     

W-based versus latent variables spatial autoregressive models: evidence from Monte Carlo simulations

In this paper, we compare by means of Monte Carlo simulations two approaches to take spatial autocorrelation into account: the classical spatial autoregressive model and the structural equations model with latent variables. The former accounts for spatial dependence and spillover effects in georeferenced data by means of a spatial weights matrix W. The latter represents spatial dependence and spillover effects by means of a latent variable in the structural (regression) model while the observed spatially lagged variables are related to the latent spatial dependence variable in the measurement model. The simulation results based on Anselin’s Columbus, Ohio, crime data set show that the misspecified latent variables approach slightly trails the correctly specified classical approach in terms of bias and root mean squared error of the coefficient estimators.     

Effect of Compression on the Crystallization Behavior and Corrosion Resistance of Al86Ni9La5 Amorphous Alloy

The effect of compression on the crystallization behavior and corrosion resistance of Al(86)Ni9La5 amorphous ribbons was investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning elec-tron microscopy (SEM) and electrochemistry test. The XRD and TEM results reveal that the compressed Al(86)Ni9La5 ribbons spun with the circumferential speed (R) of 29.3 m/s are in fully amorphous state; however, the compressed ribbons spun with R=14.7 m/s have crystalline phases embedded in the amorphous matrix. The SEM images indicate that after compression, the toughness of the ribbons increases. Electrochemical results show that the compression decreases the stability of the passive film of the Al(86)Ni9La5 amorphous ribbons, because of the compression-introduced free volume, shear bands and crystalline phases; meanwhile, with R=14.7 m/s, the compression-induced crystalline phases in the Al(86)Ni9La5 ribbons increase the corrosion potential.     

注入式混合型有源电力滤波器控制器的研制

针对配电网10 kV高压侧对大容量谐波抑制和无功补偿的要求,提出了注入式混合型有源电力滤波器(IHAPF)拓扑结构.在分析其基本工作原理的基础上,建立了IHAPF的数学模犁.针对其数学模型,提出采川递推积分算法进行控制,可以实现给定电流的尤稳态误差跟踪和对负载扰动信号的抑制,因为对控制器的实时性要求比较高.采用了双DSP控制器.并对控制器的硬件结构组成以及所包含的软件功能模块进行了说明.实验结果证明了所采用控制算法及控制器软硬件结构的有效性.     

新型并联混合有源滤波器中直流侧电压抬升问题及其解决措施

研究一种兼具大容量无功补偿能力的注入式并联混合有源滤波器,并分析其在工程应用中发现的直流侧电压抬升现象及这种现象产生的原因,在此基础上提出从采用多重化主电路结构、滞环控制法、回灌电流前馈控制法和脱离整流电源直接对直流侧电压进行控制等几个方面来抑制直流侧电压抬升的方法。考虑到是在原有已应用的系统上进行完善来避免直流侧电压的抬升,采用相对方便和简单的滞环控制和回灌电流前馈控制相结合的方法。仿真和现场应用结果证明所提出的方法能有效抑制直流侧电压的抬升,从而保障系统的安全稳定运行。     

紫外光直写杂化溶胶-凝胶SiO2光波导器件

利用有机/无机杂化方法制备了光敏性溶胶-凝胶(sol-gel)SiO2材料,在硅基片上旋涂成膜.研究了薄膜折射率和厚度随紫外曝光时间、后烘温度及时间等外界工艺条件的变化关系.利用紫外光直写技术,制作出1×2,1×4多模干涉(MMI)型分束器,并且观测到了分光效果较好的近场输出图像.     

空混气作为中国天然气调峰储备气源的必要性和可行性

近年来,中国北方冬季采暖季时常爆发大面积供气紧张,由于我国能源结构中富煤、贫油、少气的资源禀赋,再加上近年“煤改气”项目的大范围落地实施,加剧了天然气供应的紧张形势。为了提高国内天然气供应的保障度,在分析近年频发天然气供气紧张危机成因和目前常见天然气储备方案特点的基础上,提出了气态液化石油气掺混空气（以下简称空混气）作为调峰储备气源的方案,并对其必要性和可行性进行了讨论。研究结果表明：①储气能力不足已成为制约我国天然气产业可持续发展的瓶颈,国内大量进口LNG的做法形成了天然气对外依存度过高的危机;②空混气可作为适合的天然气替代产品和调峰储备气源;③空混气具有建设投入少、维护简单,安全性好、不需要额外的燃气系统、地下管网与调压设施等可与天然气通用、可避免重复投资浪费,点供更加便捷灵活,可以实时启动”等优势和价值。结论认为：①空混气是切实可行的天然气调峰储备气源,管输气用户可以根据自身特点和实际需求,合理考虑选择压缩天然气、液化天然气、空混气或者其组合作为储气气源;②未来能源发展应注重品种、渠道多元化,应从国家能源战略储备安全的角度,最大限度地满足地方燃气调峰储备要求,实现多气源、多气种的融合发展。