Monolithically integrated grating cavity tunable lasers

A novel grating cavity tunable laser is proposed and experimentally demonstrated. It is realized by monolithically integrating a semiconductor optical amplifier, a dispersive element, a phase-control section, and an etched diffraction grating in a single chip. Tuning operation is based on electrically controlled beam deflection provided by dispersive element and phase matching by phase-control section. With the electrical control, the wavelength tuning of 8.5 nm with a sidemode suppression ratio of about 35 dB has been successfully achieved.     

Ontology-driven hypothesis generation to explain anomalous patient responses to treatment

Within the medical domain there are clear expectations as to how a patient should respond to treatments administered. When these responses are not observed it can be challenging for clinicians to understand the anomalous responses. The work reported here describes a tool which can detect anomalous patient responses to treatment and further suggest hypotheses to explain the anomaly. In order to develop this tool, we have undertaken a study to determine how Intensive Care Unit (ICU) clinicians identify anomalous patient responses; we then asked further clinicians to provide potential explanations for such anomalies. The high level reasoning deployed by the clinicians has been captured and generalised to form the procedural component of the ontology-driven tool. An evaluation has shown that the tool successfully reproduced the clinician’s hypotheses in the majority of cases. Finally, the paper concludes by describing planned extensions to this work.     

Visible PL Phenomenon at Room Temperature in Disordered Structure of SrWO4 Powder

The SrWO₄ (SWO) powders were synthesized by the polymeric precursor method and annealed at different temperatures. The SWO structure was obtained by X-ray diffraction and the corresponding photoluminescence (PL) spectra was measured. The PL results reveal that the structural order–disorder degree in the SWO lattice influences in the PL emission intensity. Only the structurally order–disordered samples present broad and intense PL band in the visible range. To understand the origin of this phenomenon, we performed quantum-mechanical calculations with crystalline and order–disordered SWO periodic models. Their electronic structures were analyzed in terms of band structure. The appearance of localized levels in the band gap of the order–disordered structure was evidenced and is a favorable condition for the intense PL to occur.     

Surface copper enrichment by reduction of copper chromite catalyst employed for carbon monoxide oxidation

The effect of prereduction on CO oxidation activity of unsupported copper-chromite oxide catalysts was examined. Results were found to be in good agreement with two mechanisms for a surface copper enrichment due to CO prereduction which produced an activity increase in the copper-chromite catalyst.     

Measurement uncertainties arising from unpowered shipment of dcvoltage references

We have measured the hysteresis in output voltage arising from loss of power for three Fluke 732B dc voltage references. Continuously powering the internal temperature-controlled oven provides the best accuracy with such Zener-diode-based dc voltage references. Batteries are used to provide power continuity when shipping between laboratories. We have shown that for these particular instruments, an apparent hysteresis induced by humidity is likely to dominate any hysteresis arising from loss of battery power when transit between laboratories takes three days or more. Our conclusion is that as much, if not more, care needs to be taken when dealing with humidity than with loss of battery power when shipping between laboratories. When the highest accuracy of dc voltage comparison is required, it becomes necessary to apply voltage corrections using the measured values of humidity coefficients and the relative humidity occurring during transit     

Hydrogen‐Bonding‐Driven Enantioselective Resolution against the Kazlauskas Rule To Afford γ‐Amino Alcohols by Candida rugosa Lipase

Most lipases resolve secondary alcohols in accordance with the “Kazlauskas rule” to give the R enantiomers. In a similar manner to other lipases, Candida rugosa lipase (CRL) exhibits R enantioselectivity towards heptan‐2‐ol, although the enantiomeric ratio (E) is low (E=1.6). However, unexpected enantioselectivity (i.e., S enantioselectivity, E=58) of CRL towards 4‐(tert‐butoxycarbonylamino)butan‐2‐ol, which has a similar chain length to heptan‐2‐ol, has been observed. To develop a deeper understanding of the molecular basis for this unusual enantioselectivity, we have conducted a series of molecular modeling and substrate engineering experiments. The results of these computational and experimental analyses indicated that a hydrogen bond between the Ser450 residue and the nitrogen atom of the carbamate group is critical to stabilize the transition state of the S enantiomer.     

A Fully-Differential Complementary Hartley VCO in 0.18 m CMOS Technology

In this letter, a new complementary Hartley (C-Hartley) voltage controlled oscillator (VCO) with fully differential outputs is proposed, in which the self-biasing configuration is introduced to solve the biasing difficulty of a Hartley VCO by employing a five-port transformer. The proposed C-Hartley VCO with the center frequency of 5.6 GHz is implemented in a 1P6M 0.18 $mu$m CMOS process. The measurement result shows that the phase noise is ${-}123.6$ dBc/Hz at 1 MHz offset frequency, while dissipating 6.5 mA from 1.6 V supply with the FOM of ${-}188.5$ dBc.      

Background arsenic concentrations in Southeastern Spanish soils

The arsenic content in the province of Granada (SE Spain) was quantified, based on 93 soils at two different depths and their corresponding parent materials. The arsenic concentrations fit a log-normal distribution. Four different statistical procedures to estimate the arsenic background range in the region were tested. Upper background limits clearly exceeded limits reported for natural soils when based on the Tukey box plot or means and standard deviations of the dataset (M+/-2sdev) or of the calculated distribution function (Mf+/-2sigma) but not when based on median values (Md+/-2MAD). The relative cumulative frequency curve not only adequately estimates the background range but also delivers a clear and detailed visualisation of the data distribution and identifies subpopulations with specific background ranges related to combinations of parent materials and degree of soil development.