模电教学中工程观念的培养

"模拟电子线路"课程是工科本科电子信息类专业的一门重要的专业基础课程.本文以集成运放电路在压力检测中的应用为例,探讨了模拟电子线路课程教学中如何将理论联系实际、如何培养工程观念、如何将基本理论与工程应用相结合等问题.通过课程教案示例,阐述了工程观念的培养在教学实践中的具体做法.     

Wire-in-Wire TiO2/C Nanofibers Free-Standing Anodes for Li-Ion and K-Ion Batteries with Long Cycling Stability and High Capacity

Wearable and portable mobile phones play a critical role in the market,and one of the key technologies is the flexible electrode with high spe-cific capacity an...     

CAR T Cell Therapy in Hematological Malignancies: Implications of the Tumor Microenvironment and Biomarkers on Efficacy and Toxicity

Chimeric antigen receptor (CAR) T cell therapy has ushered in a new era in cancer treatment. Remarkable outcomes have been demonstrated in patients with previously untreatable relapsed/refractory hematological malignancies. However, optimizing efficacy and reducing the risk of toxicities have posed major challenges, limiting the success of this therapy. The tumor microenvironment (TME) plays an important role in CAR T cell therapy’s effectiveness and the risk of toxicities. Increasing research studies have also identified various biomarkers that can predict its effectiveness and risk of toxicities. In this review, we discuss the various aspects of the TME and biomarkers that have been implicated thus far and discuss the role of creating scoring systems that can aid in further refining clinical applications of CAR T cell therapy and establishing a safe and efficacious personalised medicine for individuals.     

HXD2技术提升电力机车潜在电路分析及设计改进

根据蓄电池上电、接地检测、机车照明等控制电路结构,对HXD2技术提升电力机车的潜在电路进行分析,找出控制电源接地故障的原因,并改进电路结构设计,消除潜在电路,解决接地故障误报问题。     

一种在抢险抗灾中保障特殊用户通信畅通的无线接入网络应急方案——GSM用户接入等级控制

在某些特殊情况下,移动运营商希望能够实现用户的分级接入网络,以保障一些特殊用户的通信畅通。尤其是在地震、洪灾等自然灾害造成了部分地区通信严重受损的情况下,保障特殊用户的通信顺畅就显得更加重要了。针对这种需求,本文重点介绍了接入等级控制的方案,而且还将此方案与增强多级优先和抢占的方案在实现难度和最终效果等方面进行了简单的对比。     

某市内河采用曝气辅助治理方案探讨

东莞运河在莞城段上游采用一级强化处理,处理后尾水排入下游莞城段运河,由于尾水中仍然存在污染物和还原性物质以及河流底泥的好氧作用,需要对该段河流进一步维护复氧。着重探讨了东莞城段运河维护复氧方式、需氧量计算模型、复氧设备的布置形式等,计算得出经曝气的河流末段还原物氧浓度下降了2.492 mg/L、BOD5浓度下降了1.217mg/L、NH3 -H浓度下降了0.322mg/L。     

UpG法用于辐射损伤的量效关系研究

应用常规染色体制作法和紫外线照射加吉姆萨染色法(Ultraviolet plus GienlSa technology,UpG)检测经60Coγ射线离体照射后的人外周血淋巴细胞染色体畸变率(双着丝粒体 环),研究其剂量-效应关系,探讨UpG法用于辐射损伤的剂量估算效果.实验结果表明:两种方法得出的染色体畸变率与照射剂量密切相关(P<0.05),均可用于辐射损伤的量效关系研究.两种方法的结果相比,在同一照射剂量下,UpG法高于常规法,具有显著性差异(P<0.05).UpG法可以很好用于辐射损伤的剂量估算中,且较为准确、灵敏.     

Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence,Severity, and Treatment Response

Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.     

丙烯酸酯类反应性微凝胶的制备及其对环氧树脂的增韧作用

采用自稳定分散聚合法,制备了粒径在20nm左右、粒径分布均匀的球形丙烯酸酯类反应性微凝胶;同时研究了其对环氧树脂/间苯二胺(MPDA)体系的增韧效果.结果表明,所制备的丙烯酸酯类反应性微凝胶在室温下呈橡胶态;它是环氧树脂/MPDA体系的一种有效增韧荆,增韧效果受其用量、官能团种类及用量的影响;含有环氧基团的微凝胶颗粒,增韧效果最好,而且提高了环氧树脂的热性能:带有环氧基团的微凝胶颗粒用量越大,或丙烯酸酯类微凝胶中环氧基团的摩尔分数越高,对环氧树脂的增韧效果越好.     

Design of Networked Control Systems With Packet Dropouts

This note is concerned with stability and controller design of networked control systems (NCSs) with packet dropouts. New NCS models are provided considering both single- and multiple-packet transmissions. Both sensor-to-controller (S/C) and controller-to-actuator (C/A) packet dropouts are modeled and their history behavior is described by different independent Markov chains. In term of the given models, sufficient conditions for stochastic stability are derived in the form of linear matrix inequalities (LMIs) and corresponding control laws are given. Numerical examples illustrate the effectiveness of the results.