Toward a generic approach to build up air drying models

Few versatile software programs allowing for the precise simulation of drying processes in a whole industrial plant are available. This work was done during the creation of a generic convective drying simulator for food solid particle in ProSimPlus, a chemical engineering software. Modeling approaches are discussed, and among them a compromise between first-principle modeling, reduced lab work, ability to accurately predict kinetics for a wide range of drying conditions, and low simulation time is presented. Predictive models of some required food product properties are examined. Two toolboxes were created: one estimating physical properties of foodstuffs and another simulating transfers in air and in the product. This approach is validated on four food products (with various formulations and shapes).     

Regulation of polyisoprenylated methylated protein methyl esterase by polyunsaturated fatty acids and prostaglandins

Polyisoprenylation is a set of secondary modifications involving proteins whose aberrant activities are implicated in cancers and degenerative disorders. The last step of the pathway involves an ester‐forming polyisoprenylated protein methyl transferase‐ and hydrolytic polyisoprenylated methylated protein methyl esterase (PMPMEase)‐catalyzed reactions. Omega‐3 and omega‐6 PUFAs have been linked with antitumorigeneis and tumorigenesis, respectively. PUFAs are structurally similar to the polyisoprenyl groups and may interfere with polyisoprenylated protein metabolism. It was hypothesized that PUFAs may be more potent inhibitors of PMPMEase than their more polar oxidative metabolites, the prostaglandins. As such, the relative effects of PUFAs and prostaglandins on PMPMEase could explain the association between cyclooxygenase‐2 (COX‐2) expression in tumors, the chemopreventive effects of the non‐steroidal anti‐inflammatory (NSAIDs) COX‐2 inhibitors and PUFAs. PUFAs such as AA, EPA, and DHA inhibited PMPMEase activity with K_i values of 0.12–3.7 µM. The most potent prostaglandin was 63‐fold less potent than AA. The PUFAs were also more effective at inducing neuroblastoma cell death at physiologically equivalent concentrations. The lost PMPMEase activity in AA‐treated degenerating cells was restored by incubating the lysates with COX‐1 or COX‐2. PUFAs may thus be physiological regulators of cell growth and could owe these effects to PMPMEase inhibition. Practical applications: Some PUFAs have been widely reported to have anticancer benefits. However, the molecular mechanisms for these effects are not well understood. The findings in the current paper appear to suggest that inhibition of PMPMEase may underlie their effects. They also imply that the expression of COX‐2 in various tumors may serve to convert the PUFAs into significantly less inhibitory prostaglandins. From these findings, AA and the other PUFAs, rather than being substrates for the synthesis of tumorigenic agents may actually contribute in suppressing cell proliferation. This being congruent with the lower cancer risks associated with long term use of anti‐inflammatory agents, the practical implications will likely include the nutritional and/or therapeutic management of cancer with the goal of maintaining suitable levels of the fatty acids in tissues.     

Replication-Deficient Lymphocytic Choriomeningitis Virus-Vectored Vaccine Candidate for the Induction of T Cell Immunity against Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) represents a major burden to global health, and refined vaccines are needed. Replication-deficient lymphocytic choriomeningitis virus (rLCMV)-based vaccine vectors against cytomegalovirus have proven safe for human use and elicited robust T cell responses in a large proportion of vaccine recipients. Here, we developed an rLCMV vaccine expressing the Mtb antigens TB10.4 and Ag85B. In mice, rLCMV elicited high frequencies of polyfunctional Mtb-specific CD8 and CD4 T cell responses. CD8 but not CD4 T cells were efficiently boosted upon vector re-vaccination. High-frequency responses were also observed in neonatally vaccinated mice, and co-administration of rLCMV with Expanded Program of Immunization (EPI) vaccines did not result in substantial reciprocal interference. Importantly, rLCMV immunization significantly reduced the lung Mtb burden upon aerosol challenge, resulting in improved lung ventilation. Protection was associated with increased CD8 T cell recruitment but reduced CD4 T cell infiltration upon Mtb challenge. When combining rLCMV with BCG vaccination in a heterologous prime-boost regimen, responses to the rLCMV-encoded Mtb antigens were further augmented, but protection was not significantly different from rLCMV or BCG vaccination alone. This work suggests that rLCMV may show utility for neonatal and/or adult vaccination efforts against pulmonary tuberculosis.     

Considerations for Synchronization in Body Area Networks for Human Activity Monitoring

In this paper, we highlight considerations for synchronization issues in body area networks. Requirements for the synchronization accuracy in body area networks depend on the application at hand. Synchronization may be needed for power management, sample ordering, calculation of stimulus responses and for sensor fusion. This paper provides a theoretical exercise to help understand the accuracy required for typical human motion sensing. It gives an overview of various synchronisation strategies used and implemented in prototype systems. Lessons learnt from practical implementations using Bluetooth, an IEEE 802.15.4 proprietary network and Nanonet are presented to illustrate the principles involved. The discussion provides some considerations and the requirements for typical WBAN applications.     

Experimental Study on the Use of Positive Pressure Ventilation for Fire Service Interventions in Buildings with Staircases

During fire service interventions, positive pressure ventilation (PPV) systems with mobile fans are often used to try and make (or keep) a staircase smoke free and to remove smoke from the fire rooms. The positioning (distance from the door opening) and inclination angle of the fan determine the effect of the PPV fans in the staircase. In the present paper results are discussed of an experimental study, performed at full-scale. Based on different sets of cold experiments, the impact is quantified of: the distance between the fan and the door; the inclination angle of a single fan; and the use of multiple fans. The closer the single fan is put to the door opening, the more effective the PPV becomes. Obviously, there is a trade-off with effectiveness of the fire service intervention, since the fan must not block the door opening. With respect to inclination, it is best to apply an inclination angle of 75° (i.e., an upward tilting of the fan axis by 15°, which is the maximum value tested) for ventilation at ground level with the fan tested. This ensures safety in the case of fire at ground level due to full coverage of the entry door opening, while only a relatively limited loss in PPV effectiveness is observed compared to a horizontal fan (in some cases, the PPV effectiveness is even higher with inclined fan). When the fire room is at a higher floor, an inclination angle of 90° (i.e. horizontal fan axis) can generate a higher average flow velocity, depending on the staircase configuration inside the building. If two fans are used, V-shape positioning is shown to be more effective than a set-up in series or in parallel. A V-shape with inner angle of 60° between the fan axes is more effective than an angle of 90°. If three fans are available, still higher average flow velocities are measured. Positioning two fans outside in V-shape and one fan inside at the bottom of the staircase is more effective than putting the three fans outside, On the other hand, the latter set-up may be required for firefighting tactics.     

Disassembly sequencing: A survey

This paper is a survey of the presently available literature on disassembly sequencing, including the papers that are closely related to this topic. Disassembly theory is applied to complex products such as mechanical, electromechanical and electronic appliances. It is required for end-of-life processing and for maintenance and repair. Apart from these applications, disassembly is studied for supporting the analysis of assembly processes. Disassembly sequencing involves the search for all possible disassembly sequences and the selection of the optimum solution out of these. In each application, a slightly different approach can be observed, including level of detail, degrees of freedom, and the role of uncertainty. Disassembly sequencing also plays a major role in the modern design process and is an invaluable tool in concurrent engineering. Its connection with the more detailed or component level and the less detailed level or process level including logistics, is highlighted. This presentation of the state of the art is intended as a stimulus for further research in this interesting field.     

Amber: the organic gemstone

Resins are produced by woody plants on a worldwide basis. We have found several distinct classes of modern diterpenoid resins based phenomenologically on the solid-state (13)C NMR spectra of the bulk material. Resin fossilizes over millions of years into a robust material sometimes called amber. We have characterized several hundred samples of fossil resin by solid-state (13)C NMR spectroscopy. We can relate one globe-spanning group of fossil resins to the modern genus Agathis, based on spectral evolution over time. A second large group has not been related with certainty to specific modern plants. Fossil resins from Europe fall into two categories, the famous Baltic ambers and another that resembles the Agathis group. Fossil resins from the Americas and Africa are closely related to the modern genus Hymenaea. Based on spectral distinctions, fossil resin found in an archaeological context sometimes can be assigned to a specific geographical origin on the basis of its (13)C NMR spectrum.     

Systematic Evaluation of One-Dimensional Unsteady Friction Models in Simple Pipelines

In this paper, basic unsteady flow types and transient event types are categorized, and then unsteady friction models are tested for each type of transient event. One important feature of any unsteady friction model is its ability to correctly model frictional dissipation in unsteady flow conditions under a wide a range of possible transient event types. This is of importance to the simulation of transients in pipe networks or pipelines with various devices in which a complex series of unsteady flow types are common. Two common one-dimensional unsteady friction models are considered, namely, the constant coefficient instantaneous acceleration-based model and the convolution-based model. The modified instantaneous acceleration-based model, although an improvement, is shown to fail for certain transient event types. Additionally, numerical errors arising from the approximate implementation of the instantaneous acceleration-based model are determined, suggesting some previous good fits with experimental data are due to numerical error rather than the unsteady friction model. The convolution-based model is successful for all transient event types. Both approaches are tested against experimental data from a laboratory pipeline.