Adult rats stressed as neonates show exaggerated behavioral responses to both pharmacological and environmental challenges.

Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmental challenge (restraint). Previously isolated animals demonstrated increased activity compared to controls at both drug doses. Similarly, isolated animals manifested exaggerated inhibition of activity after restraint. Previously isolated animals usually did not show differences compared to controls under baseline conditions (saline injection or no restraint). The neuroplastic changes that result from the neonatal experience are long lasting and appear when the system is challenged. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Thermal Conductivity/Diffusivity of Silicon Carbide Whisker Reinforced Mullite

The thermal conductivity and diffusivity of silicon carbide whisker reinforced mullite was shown to increase with whisker content. This effect was much greater for vapor-liquid-solid (VLS) whiskers than for rice-hull (RH) whiskers. This suggests that the thermal conductivity for the VLS whiskers was significantly higher than for the RH whiskers. Due to preferred orientation of the whiskers, thermal conductivity and diffusivity of the composite samples exhibited significant anisotropy.     

Synthesis of deuterated cyclopropene fatty esters structurally related to palmitic and myristic acids

To develop a synthesis of tritiated cyclopropene fatty acids (CPFA), compounds that should prove useful for affinity labeling of desaturases in insect pheromone biosynthetic studies, a series of novel, selectively deuterated CPFA analogues was prepared and characterized. In methyl [16-²H]12,13-methylene-12-hexadecenoate, the incorporation of deuterium was achieved by treatment of the corresponding ω-chloro derivative with sodium borodeuteride in dimethylsulfoxide at 70°C for 24 h (67% yield) following conventional procedures. Alkylation of the tetrahydropyranyl derivative of 13-tridecynol in the presence of lithium diisopropylamide in tetrahydrofuran at −20°C with 1-chloro-3-iodopropane in hexamethylphosphoramide, followed by Jones oxidation of the crude product, yielded 16-chloro-12-hexadecynoic acid (54%), which was esterified to the corresponding methyl ester by treatment with potassium carbonate and methyl iodide in dimethylformamide. Treatment of this acetylenic ester with ethyldiazoacetate in the presence of activated copper-bronze as catalyst followed by hydrolysis in KOH solution at room temperature yielded 16-chloro-12,13-(carboxymethylene)-12-hexadecenoic acid. This diacid was treated with excess oxalyl chloride to give the corresponding diacyl chloride, which was decarbonylated in a diethyl ether solution with zinc chloride, and the cyclopropenium ions thus formed were added at −40°C to a methanolic sodium hydroxide solution of sodium borohydride to give methyl 16-chloro-12,13-methylene-12-hexadecenoate. Analogous procedures were followed to prepare methyl [17-²H]10,11-methylene-10-hexadecenoate, methyl [17-²H]11,12-methylene-11-hexadecenoate and methyl [17-²H]12,13-methylene-12-hexadecenoate from the corresponding diacids using sodium borodeuteride in the reduction of the cyclopropenium ions. Alternatively, methyl [2,2,3,3-²H₄]hexadecynoate, prepared by reaction of methyl 2,11-hexadecadiynoate with magnesium in deuterated methanol at room temperature, was submitted to the above cyclopropenylation and reductive decarbonylation sequence to give methyl [2,2,3,3,17-²H₅]-11,12-methylene-11-hexadecenoate. In summary, complementary methods for the selective incorporation of one to five deuterium atoms into cyclopropene fatty acids, at different sites, in moderate to high yields have been developed. The methods should easily be applicable to the preparation of the corresponding tritiated analogues.     

Students Weigh In: Usability Test of Online Library Tutorials

Librarians can improve their online tutorials by borrowing usability testing techniques from the computer science field to improve the human-computer interface. This study involved a multimethod usability test of librarian-created tutorials to determine what students learned, how they felt on several affective questions, and what they suggested for improving the tutorials. Results of pre- and post-tests showed that student knowledge increased, and surveys and focus group findings lean to several suggestions for improving engagement and placing tutorials where they will be most effective. This case study demonstrates the value of user input to improve the effectiveness of online instruction for information literacy.     

Identifying and understanding urban sport areas using Nokia Sports Tracker

Current advancements in pervasive technologies allow users to create and share an increasing amount of whereabouts data. Thus, some rich datasets on human mobility are becoming available on the web. In this paper we extracted approximately 790,000 mobility traces from a web-based repository of GPS tracks—the Nokia Sports Tracker Service. Using data mining mechanisms, we show that this data can be analyzed to uncover daily routines and interesting schemes in the use of public spaces. We first show that our approach supports large-scale analysis of people’s whereabouts by comparing behavioral patterns across cities. Then, using Kernel Density Estimation, we present a mechanism to identify popular sport areas in individual cities. This kind of analysis allows us to highlight human-centered geographies that can support a wide range of applications ranging from location-based services to urban planning.     

Comparison of paper-and-pencil versus Web administration of the Youth Risk Behavior Survey (YRBS): Participation,data quality,and perceived privacy and anonymity

The Youth Risk Behavior Surveillance System (YRBSS) monitors priority health-risk behaviors among US high school students. To better understand the ramifications of changing the YRBSS from paper-and-pencil to Web administration, in 2008 the Centers for Disease Control and Prevention conducted a study comparing these two modes of administration. Eighty-five schools in 15 states agreed to participate in the study. Within each participating school, four classrooms of students in grades 9 or 10 were randomly assigned to complete the Youth Risk Behavior Survey questionnaire in one of four conditions (in-class paper-and-pencil, in-class Web without programmed skip patterns, in-class Web with programmed skip patterns, and “on your own” Web without programmed skip patterns). Findings included less missing data for the paper-and-pencil condition (1.5% vs. 5.3%, 4.4%, 6.4%; p < .001), less perceived privacy and anonymity among respondents for the in-class Web conditions, and a lower response rate for the “on your own” Web condition than for in-class administration by either mode (28.0% vs. 91.2%, 90.1%, 91.4%; p < .001). Although Web administration might be useful for some surveys, these findings do not favor the use of a Web survey for the YRBSS.     

Thesaurus enrichment for query expansion in audiovisual archives

It is common practice in audiovisual archives to disclose documents using metadata from a structured vocabulary or thesaurus. Many of these thesauri have limited or no structure. The objective of this paper is to find out whether retrieval of audiovisual resources from a collection indexed with an in-house thesaurus can be improved by enriching the thesaurus structure. We propose a method to add structure to a thesaurus by anchoring it to an external, semantically richer thesaurus. We investigate the added value of this enrichment for retrieval purposes. We first anchor the thesaurus to an external resource, WordNet. From this anchoring we infer relations between pairs of terms in the thesaurus that were previously unrelated. We employ the enriched thesaurus in a retrieval experiment on a TRECVID 2007 dataset. The results are promising: with simple techniques we are able to enrich a thesaurus in such a way that it adds to retrieval performance.     

Oris: a tool for modeling, verification and evaluation of real-time systems

Oris is a tool for qualitative verification and quantitative evaluation of reactive timed systems, which supports modeling and analysis of various classes of timed extensions of Petri Nets. As most characterizing features, Oris implements symbolic state space analysis of preemptive Time Petri Nets, which enable schedulability analysis of real-time systems running under priority preemptive scheduling; and stochastic Time Petri Nets, which enable an integrated approach to qualitative verification and quantitative evaluation. In this paper, we present the current version of the tool and we illustrate its application to two different case studies in the areas of qualitative verification and quantitative evaluation, respectively.     

Reliability of physiological and subjective responses to physical and psychosocial exposures during a simulated manufacturing task

Responses to physical and psychosocial exposures can be measured using diverse methods, but their reliability, particularly under multiple exposures, is largely unknown. Five classes of methods were used to assess physiological and subjective responses among 24 participants to four combinations of physical and psychosocial exposures while performing two identical sessions of a simulated overhead manufacturing task. As an exploratory analysis, test–retest reliability was quantified using intraclass correlation coefficients (ICC) and coefficients of variation (CV). Discomfort ratings were reliable under less favorable exposures, and ratings of the psychosocial environment were most reliable under favorable social support. Workload ratings were most reliable with high physical exposure and favorable social support, and task performance was reliable overall. EMG and heart rate had relatively low reliability. Slightly less than half of the variables were considered reliable, but reliability depended on exposure conditions.Relevance to industry: The study provides information on the reliability of commonly used exposure measurement methods. The results can guide the selection of physiological and psychological work outcome measurements in future studies and work evaluations.