国家的门脸儿——南非使领馆设计

国家强大了!国人有钱了!经过30年的快速发展,中国在世界的地位发生了巨大的变化,中国人在外国人面前腰杆也挺起来了.然而在人们对中国经济的飞跃发展充满好奇和羡慕的同时,也对中国人处事态度的变化产生疑虑和担心.外交使团代表着国家的风范,使领馆建筑也代表着国家的形象.因此,设计使领馆建筑多少担负着表达中国精神和传递文化品味的重任.9年前我们有幸承担了中国驻南非使领馆的设计工作,在创作中得到外交部和使馆各级领导的大力支持,他们彬彬有礼的作风、既相互尊重又坚持原则的办事态度以及对国际文化交流的设想,给了我们很大的启发和激励,使我们明确了尊重环境、和谐内敛、追求精致典雅文化气质的创作思路,设计工作由此顺利展开.     

保护剂对混凝土耐久性影响研究

针对无机硅类、硅烷类和有机共聚物3类保护剂对混凝土耐久性的影响进行了研究。重点研究了混凝土涂刷保护剂后吸水率、抗Cl-渗透性能、抗碳化性能、耐污染性能指标的变化,通过以上4项指标综合评定混凝土保护剂对混凝土耐久性的影响。     

A CCD-based reader combined with CdS quantum dot-labeled lateral flow strips for ultrasensitive quantitative detection of CagA

Immunochromatographic assays are widely used to detect many analytes. CagA is proved to be associated closely with initiation of gastric carcinoma. Here, we reported that a charge-coupled device (CCD)-based test strip reader combined with CdS quantum dot-labeled lateral flow strips for quantitative detection of CagA was developed, which used 365-nm ultraviolet LED as the excitation light source, and captured the test strip images through an acquisition module. Then, the captured image was transferred to the computer and was processed by a software system. A revised weighted threshold histogram equalization (WTHE) image processing algorithm was applied to analyze the result. CdS quantum dot-labeled lateral flow strips for detection of CagA were prepared. One hundred sera samples from clinical patients with gastric cancer and healthy people were prepared for detection, which demonstrated that the device could realize rapid, stable, and point-of-care detection, with a sensitivity of 20 pg/mL.     

沥青混凝土道路铺设技术探讨

随着交通压力的增加,沥青混凝土路面在使用过程中逐渐显现出许多质量问题。本文在分析影响沥青混凝土道路铺设技术应用因素的基础上,探究沥青混凝土道路铺设技术要点,以有效提高沥青混凝土施工技术,增强公路工程施工质量与安全。     

Genome-Wide Identification and Expression Analysis of Fatty Acid Desaturase (FAD) Genes in Camelina sativa (L.) Crantz

Camelina sativa (L.) Crantz is an indispensable oilseed crop, and its seeds contain many unsaturated fatty acids. FAD (fatty acid desaturase) regulates the synthesis of unsaturated fatty acids. In this research, we performed CsFAD gene family analysis and identified 24 CsFAD genes in Camelina, which were unevenly distributed on 14 of the 19 total chromosomes. Phylogenetic analysis showed that CsFAD includes four subfamilies, supported by the conserved structures and motifs of CsFAD genes. In addition, we investigated the expression patterns of the FAD family in the different tissues of Camelina. We found that CsFAD family genes were all expressed in the stem, and CsFAD2-2 was highly expressed in the early stage of seed development. Moreover, during low temperature (4 °C) stress, we identified that the expression level of CsFAD2-2 significantly changed. By observing the transient expression of CsFAD2-2 in Arabidopsis protoplasts, we found that CsFAD2-2 was located on the nucleus. Through the detection and analysis of fatty acids, we prove that CsFAD2-2 is involved in the synthesis of linolenic acid (C18:3). In conclusion, we identified CsFAD2-2 through the phylogenetic analysis of the CsFAD gene family and further determined the fatty acid content to find that CsFAD2-2 is involved in fatty acid synthesis in Camelina.     

FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro

Factor-VII-activating protease (FSAP) is involved in the regulation of hemostasis and inflammation. Extracellular histones play a role in inflammation and the conversion of latent pro-FSAP into active FSAP. FSAP has been shown to regulate endothelial permeability, but the mechanisms are not clear. Here, we have investigated the effects of FSAP on endothelial permeability in vitro. A mixture of histones from calf thymus stimulated permeability, and the wild-type (WT) serine protease domain (SPD) of FSAP blocked this effect. WT–SPD–FSAP did not influence permeability on its own, nor that stimulated by thrombin or vascular endothelial growth factor (VEGF)-A₁₆₅. Histones induced a large-scale rearrangement of the junction proteins VE-cadherin and zona occludens-1 from a clear junctional distribution to a diffuse pattern. The presence of WT–SPD–FSAP inhibited these changes. Permeability changes by histones were blocked by both TLR-2 and TLR4 blocking antibodies. Histones upregulated the expression of TLR-2, but not TLR-4, in HUVEC cells, and WT–SPD–FSAP abolished the upregulation of TLR-2 expression. An inactive variant, Marburg I (MI)–SPD–FSAP, did not have any of these effects. The inhibition of histone-mediated permeability may be an important function of FSAP with relevance to sepsis, trauma, and stroke and the need to be investigated further in in vivo experiments.     

Cartilage Oligomeric Matrix Protein,Diseases, and Therapeutic Opportunities

Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic reticulum stress and chondrocyte apoptosis, resulting in rare skeleton diseases. The bouquet-like structure of COMP allows it to act as a bridging molecule that regulates cellular phenotype and function. COMP is able to interact with many other ECM components and binds directly to a variety of cellular receptors and growth factors. The roles of COMP in other skeleton diseases, such as osteoarthritis, have been implied. As a well-established biochemical marker, COMP indicates cartilage turnover associated with destruction. Recent exciting achievements indicate its involvement in other diseases, such as malignancy, cardiovascular diseases, and tissue fibrosis. Here, we review the basic concepts of COMP and summarize its novel functions in the regulation of signaling events. These findings renew our understanding that COMP has a notable function in cell behavior and disease progression as a signaling regulator. Interestingly, COMP shows distinct functions in different diseases. Targeting COMP in malignancy may withdraw its beneficial effects on the vascular system and induce or aggravate cardiovascular diseases. COMP supplementation is a promising treatment for OA and aortic aneurysms while it may induce tissue fibrosis or cancer metastasis.     

深凹露天矿采场内流场分布规律的试验与数值模拟

为探究大气风速对深凹露天矿山爆破排烟时间的影响,采用CFD数值模拟方法构建了深凹露天矿山爆破非稳态数值模型,模拟大气风速为3、6、9、15 m/s和不同爆破位置条件下炮烟扩散场景,研究了不同大气风速对深凹露天采坑内风流场特征和爆破排烟时间的影响。研究结果表明：不同爆破位置下,随着大气风速的增大,露天采坑内的风流分布呈现出单复环流向双复环流结构的转变;当大气风速大于6 m/s后,随着大气风速的增大,爆破炮烟排烟时间下降的幅度逐渐减小,大气风速对排烟时间的影响逐渐降低;不同爆破位置下,随着大气风速的增大,露天采坑爆破炮烟排烟时间均呈现下降趋势,且与大气风速呈现良好的指数函数关系。

     

Two-Timescale Online Learning of Joint User Association and Resource Scheduling in Dynamic Mobile Edge Computing

For the mobile edge computing network consisting of multiple base stations and resource-constrained user devices, network cost in terms of energy and delay will...     

一个新的金属高温蠕变空洞形核理论模型

本文在以往的蠕变变形空洞形核模型的基础文上提出了一个新的空洞形核模型。该模型不但考虑了位错塞和所产生的应力集中的作用,同时也考虑了空位聚集的作用。从本文推导出的临界空洞半径表达式即可得出Raj等人提出的临界半径关系式,又可得出Smith等人提出的空洞形核临界应力关系式,从而说明本文提出的空洞形核模型比以往的模型具有更广泛的适用范围。