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41.
Panagiotis Theofilis Marios Sagris Evangelos Oikonomou Alexios S. Antonopoulos Konstantinos Tsioufis Dimitris Tousoulis 《International journal of molecular sciences》2022,23(6)
Platelets are at the forefront of human health and disease following the advances in their research presented in past decades. Platelet activation, their most crucial function, although beneficial in the case of vascular injury, may represent the initial step for thrombotic complications characterizing various pathologic states, primarily atherosclerotic cardiovascular diseases. In this review, we initially summarize the structural and functional characteristics of platelets. Next, we focus on the process of platelet activation and its associated factors, indicating the potential molecular mechanisms involving inflammation, endothelial dysfunction, and miRs. Finally, an overview of the available antiplatelet agents is being portrayed, together with agents possessing off-set platelet-inhibitory actions, while an extensive presentation of drugs under investigation is being given. 相似文献
42.
Vasilia Tamamouna Evangelia Pavlou Christiana M. Neophytou Panagiotis Papageorgis Paul Costeas 《International journal of molecular sciences》2022,23(22)
Cancer recurrence and metastasis, following successful treatment, constitutes a critical threat in clinical oncology and are the leading causes of death amongst cancer patients. This phenomenon is largely attributed to metastatic tumor dormancy, a rate-limiting stage during cancer progression, in which disseminated cancer cells remain in a viable, yet not proliferating state for a prolonged period. Dormant cancer cells are characterized by their entry into cell cycle arrest and survival in a quiescence state to adapt to their new microenvironment through the acquisition of mutations and epigenetic modifications, rendering them resistant to anti-cancer treatment and immune surveillance. Under favorable conditions, disseminated dormant tumor cells ‘re-awake’, resume their proliferation and thus colonize distant sites. Due to their rarity, detection of dormant cells using current diagnostic tools is challenging and, thus, therapeutic targets are hard to be identified. Therefore, unraveling the underlying mechanisms required for keeping disseminating tumor cells dormant, along with signals that stimulate their “re-awakening” are crucial for the discovery of novel pharmacological treatments. In this review, we shed light into the main mechanisms that control dormancy induction and escape as well as emerging therapeutic strategies for the eradication of metastatic dormant cells, including dormancy maintenance, direct targeting of dormant cells and re-awakening dormant cells. Studies on the ability of the metastatic cancer cells to cease proliferation and survive in a quiescent state before re-initiating proliferation and colonization years after successful treatment, will pave the way toward developing innovative therapeutic strategies against dormancy-mediated metastatic outgrowth. 相似文献
43.
44.
Panagiotis Sarantis Alexandros Bokas Adriana Papadimitropoulou Evangelos Koustas Stamatios Theocharis Pavlos Papakotoulas Dimitrios Schizas Alexandros Papalampros Evangelos Felekouras Athanasios G. Papavassiliou Michalis V. Karamouzis 《International journal of molecular sciences》2021,22(13)
Pancreatic Cancer (PC) is recognized as a highly thrombogenic tumor; thus, low-molecular-weight heparin (LMWH) such as tinzaparin is routinely used for PC patients. On the basis of combinatorial therapy approaches to treat highly malignant and refractory cancers such as PC, we hypothesized that tinzaparin can augment the effectiveness of traditional chemotherapeutic drugs and induce efficient antitumor activity. PANC-1 and MIAPaCa-2 were incubated alone or in combination with tinzaparin, nab-paclitaxel and gemcitabine. In vivo evaluation of these compounds was performed in a NOD/SCID mouse using a model injected with PANC-1. Tinzaparin enhances the anti-tumor effects of nab-paclitaxel and gemcitabine in mtKRAS PC cell lines via apoptosis in in vitro experiments. The triple combination power acts through the induction of apoptosis, reduction of the proliferative potential and angiogenesis; hence, contributing to a decrease in tumor volume observed in vivo. The triple regimen provided an extra 24.3% tumor reduction compared to the double combination (gemcitabine plus nab-paclitaxel). Combinatorial strategies can create novel therapeutic approaches for the treatment of patients with PC, achieving a better clinical outcome and prolonged survival. Further prospective randomized research is needed and the investigation of various concentrations of tinzaparin above 150 UI/Kg, would potentially provide a valuable synergistic effect to the conventional therapeutic compounds. 相似文献
45.
Panagiotis Papastamoulis 《Computational statistics & data analysis》2009,53(4):900-911
The Bayesian estimation of a special case of mixtures of normal distributions with an unknown number of components is considered. More specifically, the case where some components may have identical means is studied. The standard Reversible Jump MCMC algorithm for the estimation of a normal mixture model consisting of components with distinct parameters naturally fails to give precise results in the case where (at least) two of the mixture components have equal means. In particular, this algorithm either tends to combine such components resulting in a posterior distribution for their number having mode at a model with fewer components than those of the true one, or overestimates the number of components. This problem is overcome by defining-for every number of components-models with different number of parameters and introducing a new move type that bridges these competing models. The proposed method is applied in conjunction with suitable modifications of the standard split-combine and birth-death moves for updating the number of components. The method is illustrated by using two simulated datasets and the well-known galaxy dataset. 相似文献
46.
Nikos Nikolopoulos Aristeidis Nikolopoulos Emmanouil Karampinis Panagiotis Grammelis 《Fuel》2011,90(1):198-214
The present paper presents a three-dimensional numerical investigation of a pulverized-fuel, tangentially-fired utility boiler located at Florina/Greece under air, partial and full oxy-fuel conditions. Heat and mass transfer and major species concentration, such as CO2, CO and O2 are calculated; whilst the results for the reference air case scenario studied are in good agreement with the corresponding operational data measured in the plant, both for combustion calculations and NOx emissions. Results for the partial and full oxy-fuel operation scenarios are in line with similar experimental and numerical investigations found in the recent literature. This numerical investigation of oxy-fuel conditions scenarios prior to their implementation under real scale conditions demonstrates the utmost of its importance, since significant results regarding the operation of a boiler in terms of lignite particle trajectories and burning rates are attained. Furthermore, NOx calculations have been performed for all the examined case studies. 相似文献
47.
Panagiotis AndrianesisAuthor Vitae Pandelis BiskasAuthor Vitae 《Electric Power Systems Research》2011,81(8):1631-1642
Greece's wholesale electricity market is a mandatory pool in which the commodities of energy and ancillary services are simultaneously traded and dispatched on the generation units. In this paper, we provide an overview of the Greek wholesale electricity market with emphasis on ancillary services. Considering the wide range of ancillary services, our goal is to contribute to the growing literature on individual case studies and comparisons of different ancillary services markets worldwide, pointing out similarities and differences with other market models. In addition, we discuss several aspects, and report on some of the strengths and weaknesses of the Greek wholesale electricity market model. 相似文献
48.
Online social networks (OSNs) like Facebook, Myspace, and Hi5 have become popular, because they allow users to easily share content. OSNs recommend new friends to registered users based on local features of the graph (i.e., based on the number of common friends that two users share). However, OSNs do not exploit the whole structure of the network. Instead, they consider only pathways of maximum length 2 between a user and his candidate friends. On the other hand, there are global approaches, which detect the overall path structure in a network, being computationally prohibitive for huge-size social networks. In this paper, we define a basic node similarity measure that captures effectively local graph features (i.e., by measuring proximity between nodes). We exploit global graph features (i.e., by weighting paths that connect two nodes) introducing transitive node similarity. We also derive variants of our method that apply to different types of networks (directed/undirected and signed/unsigned). We perform extensive experimental comparison of the proposed method against existing recommendation algorithms using synthetic and real data sets (Facebook, Hi5 and Epinions). Our experimental results show that our FriendTNS algorithm outperforms other approaches in terms of accuracy and it is also time efficient. Finally, we show that a significant accuracy improvement can be gained by using information about both positive and negative edges. 相似文献
49.
Nikolaos Vernadakis Panagiotis AntoniouMaria Giannousi Eleni ZetouEfthimis Kioumourtzoglou 《Computers & Education》2011
The purpose of this study was to determine the effectiveness of a hybrid learning approach to deliver a computer science course concerning the Microsoft office PowerPoint 2003 program in comparison to delivering the same course content in the form of traditional lectures. A hundred and seventy-two first year university students were randomly assigned into two teaching method groups: traditional lecture instruction (TLI) and hybrid lecture instruction (HLI). Each group received six 95-min periods of instruction divided into 4 sections: a) 5-min brief outline of the key learning points, b) 40-min lecture on general knowledge c) 45-min constructivist-inspired learning activities and d) 5-min summary on key learning points. In the beginning and the end of this study students completed a 17-item multiple choice knowledge test. Two-way analysis of variances (ANOVA), with repeated measures on the last factor, were conducted to determine effect of method groups (TLI, HLI) and measures (pre-test, post-test) on knowledge test. The measures main effect was significant, as well as the groups x measures interaction effect. Two independent-samples t test were conducted to follow up the significant interaction. Differences in mean ratings of knowledge performance between the two teaching groups were not significantly different at first measure, while the TLI method group yielded a significantly lower mean rating at second measure. The findings indicated that HLI approach might be a superior option for undergraduate students on learning the Microsoft office PowerPoint 2003 program. 相似文献
50.
Nael H. El-Farra Author Vitae Author Vitae Panagiotis D. Christofides Author Vitae 《Automatica》2004,40(1):101-110
In this work, a hybrid control scheme, uniting bounded control with model predictive control (MPC), is proposed for the stabilization of linear time-invariant systems with input constraints. The scheme is predicated upon the idea of switching between a model predictive controller, that minimizes a given performance objective subject to constraints, and a bounded controller, for which the region of constrained closed-loop stability is explicitly characterized. Switching laws, implemented by a logic-based supervisor that constantly monitors the plant, are derived to orchestrate the transition between the two controllers in a way that safeguards against any possible instability or infeasibility under MPC, reconciles the stability and optimality properties of both controllers, and guarantees asymptotic closed-loop stability for all initial conditions within the stability region of the bounded controller. The hybrid control scheme is shown to provide, irrespective of the chosen MPC formulation, a safety net for the practical implementation of MPC, for open-loop unstable plants, by providing a priori knowledge, through off-line computations, of a large set of initial conditions for which closed-loop stability is guaranteed. The implementation of the proposed approach is illustrated, through numerical simulations, for an exponentially unstable linear system. 相似文献