新型传感材料迟环现象的智能补偿方法

从理论上阐述了对传感器迟环现象进行智能补偿的一种方法,并介绍了一个应用实例。该方法对于新型传感材料、传感器的研究与开发及应用有着重要意义。     

Application of a molecularly imprinted polymer for the effective recognition of different anti-epidermal growth factor receptor inhibitors

A molecularly imprinted polymer (MIP) was prepared using (E)-piceatannol, a natural potential anti-epidermal growth factor receptor (EGFR) inhibitor, as the template and 4-vinylpyridine as the functional monomer. The template was isolated from a Chinese traditional Tibetan medicinal herb, Caragana jubata, by a solid-phase extraction procedure. The crude extract of this herb was loaded on the MIP column for the binding test, and two different compounds besides the template itself were specifically recognized by the polymer, which were identified to be butein and quercetin possessing potent anti-EGFR tyrosine kinase activities with IC(50) values of 10 and 15 microM, respectively. Affinity and selectivity for these inhibitors and another three compounds coexisting with the template in this herb were evaluated in the chromatographic mode. For the first time, the affinity of a molecularly imprinted polymer was investigated to be correlative to the bioactivities of the analytes. The chromatographic behavior of the analytes was consistent with their activity values: the more active inhibitor was retained longer on the MIP. This research work afforded us a new approach for the effective recognition of novel anti-EGFR inhibitors from herbs by using the MIP as the receptor mimic to assay the bioactivities of reserved components, which will be very helpful in the direct separation of lead candidates for anticancer drugs.     

Frontal affinity chromatography combined on-line with mass spectrometry: a tool for the binding study of different epidermal growth factor receptor inhibitors

Frontal affinity chromatography (FAC) is a simple but powerful method to analyze molecular interactions between an analyte and an immobilized ligand by calculating the extent of retardation of the elution front. By combination of FAC with a PE-Mariner electrospray ionization mass spectrometry, a very efficient and straightforward procedure was developed herein for analyzing the binding properties of different inhibitors of the epidermal growth factor receptor (EGFR). In this study, a polyclonal antibody prepared with a known anti-EGFR inhibitor coupled with bovine serum albumin was adopted as the stationary phase in the FAC system. Using the antibody to mimic the receptor, other different anti-EGFR inhibitors as well as the small-molecule half-antigen itself were recognized directly from the crude extract of herb, which afforded us a novel promising approach for the efficient screening of lead compounds or drug candidates from natural resources.     

一种基于模糊推理的变步长自适应滤波算法

论文对现有的变步长自适应滤波算法进行了分析,并定性地给出了变步长自适应滤波算法中步长变化应满足的4条准则。根据这些准则,文章提出了一种新的基于模糊推理的变步长自适应滤波算法。理论分析和实验仿真结果都表明,新算法能够符合文中提出的变步长准则,很好地满足了收敛速度和收敛精度的要求。此外,还给出了该算法应用于回声消除中的结果。     

AlInGaN量子阱垒层材料的优化

采用k·p方法理论,考虑了极化电场和自由载流子重新分布等因素,通过薛定谔方程和泊松方程自洽求解得到InGaN/AlInGaN,InGaN/GaN,InGaN/InGaN,InGaN/AlGaN量子阱导带和价带的能带结构,并由此计算了不同量子阱结构的自发发射谱.分析对比发现AlInGaN材料特有的自发极化和压电极化效应在阱垒界面处形成的极化电荷对量子阱发光特性有重要的影响.以AlInGaN为垒,优化其中各元素的组分可以减小极化电场的影响,提高量子阱自发发射谱强度.同时,综合考虑了极化电荷和势垒高度的影响,提出了具体的优化方法,并给予了物理解释.     

海派旗袍的构成元素及其在 现代服饰设计中的应用

海派旗袍由廓形、立领、开衩、盘扣、胸襟等元素构成。随着中国经济的不断发展,服装设计界刮起了"中国风",海派旗袍元素也受到设计师们的关注,他们通过打散重构、夸张变形、中西融合等方法将海派旗袍元素应用于现代服饰设计中。     

时间序列模型在北京西山地区岩溶地下水位预测中的应用

作为北京水资源储备区,北京西山地区地下水位动态变化对北京市水资源管理具有重大意义。时间序列模型是研究预测地下水水位动态变化特征的有效方法。为了解北京西山地区地下水位未来变化趋势,本文选用北京西山地区地下水位长观序列,通过拟合序列的趋势项、周期项及随机项分量,建立地下水位动态变化模型。模型精度检验表明模型拟合程度良好,预测结果显示西山地区未来五年内地下水位呈现动态平衡状态。     

基于音素评分模型的发音标准度评测研究

在计算机辅助语言学习系统中,后验概率是普通话水平测试(PSC)电子化系统衡量考生发音标准程度的重要指标,但后验概率与人工的主观评分存在着显著差别。该文提出了“音素评分模型”的思想,对后验概率进行变换。该文研究了线性和非线性的sigmoid音素评分模型,并发现线性音素评分模型有闭式全局最优解,非线性音素评分模型可用梯度下降法求解。在全国采集的498人的普通话考试现场数据集上的实验表明该策略能使系统评分性能有明显的提升 当后验概率在全音素概率空间中计算时,可使系统性能提升约42%;当后验概率在优化的概率空间中计算时,能使系统性能提升约23%～27%。     

多民族语言本体知识库构建技术

语义本体是共享概念模型的显示的形式化规范说明,其目标是将杂乱无章的信息源转变为有序易用的知识源。语义本体知识库的构建是文本自动处理的一个重要环节,跨语言信息检索、信息抽取、自动翻译等领域中都有广泛的应用。该文旨在描述统一标准、统一接口的多民族语言本体知识库的创建思路,以及包含的若干问题,例如 多民族语言中共有概念的一般表示与各民族语言特有的事物表达方式的规律,基于词汇语义的、包括汉语、英语及少数民族语言在内的多民族语言语义本体的表示理论与方法等。